Cancer risk in patients with psoriasis: should we be paying more attention?
| Title: | Cancer risk in patients with psoriasis: should we be paying more attention? |
|---|---|
| Authors: | Loft ND; Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen , Copenhagen, Denmark.; Copenhagen Research Group for Inflammatory Skin, Herlev and Gentofte Hospital , Copenhagen, Denmark.; Vaengebjerg S; Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen , Copenhagen, Denmark.; Copenhagen Research Group for Inflammatory Skin, Herlev and Gentofte Hospital , Copenhagen, Denmark.; Skov L; Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen , Copenhagen, Denmark.; Copenhagen Research Group for Inflammatory Skin, Herlev and Gentofte Hospital , Copenhagen, Denmark. |
| Source: | Expert review of clinical immunology [Expert Rev Clin Immunol] 2020 May; Vol. 16 (5), pp. 479-492. Date of Electronic Publication: 2020 Apr 24. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Review; Video-Audio Media |
| Language: | English |
| Journal Info: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101271248 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8409 (Electronic) Linking ISSN: 1744666X NLM ISO Abbreviation: Expert Rev Clin Immunol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2015- : Abingdon, Oxford : Taylor & Francis; Original Publication: London, UK : Future Drugs Ltd., 2005- |
| MeSH Terms: | Neoplasms*/etiology ; Neoplasms*/immunology ; Psoriasis*/immunology ; Psoriasis*/therapy; Humans ; Risk Factors |
| Abstract: | Introduction: Psoriasis is a chronic-immune-mediated disease affecting 2-4% of the western population. The disease is associated with several co-morbidities including an increased risk of cancer. Concerns have been raised whether psoriasis itself, the psoriasis-associated risk factors, or the treatment of psoriasis might lead to an increased risk of cancer.; Areas Covered: We reviewed the literature on cancers associated with psoriasis and discuss some of the potential mechanisms behind the observed associations.; Expert Opinion: Patients with psoriasis have an increased risk of cancers overall and some site-specific cancers especially non-melanoma skin cancer, lymphoma, and lung cancer. The increased risk is most likely due to a combination of the chronic low-grade inflammation in psoriasis, risk factors for cancer associated with psoriasis, and the treatment of psoriasis. Future research should investigate the contribution of the individual mechanisms. Additionally, multiple new specific immunomodulatory treatments for psoriasis have been introduced during recent years and it is important to monitor and investigate whether these treatments confer an increased risk of cancers. Lastly, as patients with psoriasis have an increased alcohol use, smoke more than the general population and as psoriasis has been linked to obesity, promotion of a healthy lifestyle is key in the prevention of certain cancer types. |
| Contributed Indexing: | Keywords: Treatment; alcohol; biologics; cancer; chronic-low grade inflammation; lymphoma; non-melanoma skin cancer; obesity; psoriasis; smoking |
| Entry Date(s): | Date Created: 20200414 Date Completed: 20210819 Latest Revision: 20210819 |
| Update Code: | 20260130 |
| DOI: | 10.1080/1744666X.2020.1754194 |
| PMID: | 32279582 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't; Review; Video-Audio Media