Tumor Biomarkers for the Prediction of Distant Metastasis in Head and Neck Squamous Cell Carcinoma.
| Title: | Tumor Biomarkers for the Prediction of Distant Metastasis in Head and Neck Squamous Cell Carcinoma. |
|---|---|
| Authors: | Alfieri S; Head and Neck Cancer Medical Oncology 3 Department, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy.; Carenzo A; Integrated Biology Platform, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.; Platini F; Head and Neck Cancer Medical Oncology 3 Department, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy.; Serafini MS; Integrated Biology Platform, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.; Perrone F; Pathology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.; Galbiati D; Head and Neck Cancer Medical Oncology 3 Department, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy.; Sponghini AP; Oncology Department, University of Eastern Piedmont, Maggiore della Carità Hospital, 28100 Novara, Italy.; Depenni R; Department of Oncology and Haematology, University Hospital of Modena and Reggio Emilia, 41124 Modena, Italy.; Vingiani A; Pathology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.; Quattrone P; Pathology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.; Marchesi E; Integrated Biology Platform, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.; Iannó MF; Integrated Biology Platform, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.; Micali A; Integrated Biology Platform, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.; Mancinelli E; Integrated Biology Platform, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.; Orlandi E; Radiation Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.; Marceglia S; Department of Engineering and Architecture, University of Trieste, 34127 Trieste, Italy.; Locati LD; Head and Neck Cancer Medical Oncology 3 Department, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy.; Licitra L; Head and Neck Cancer Medical Oncology 3 Department, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy.; Department of Hematology and Oncology, University of Milan, 20122 Milan, Italy.; Bossi P; Head and Neck Cancer Medical Oncology 3 Department, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy.; De Cecco L; Integrated Biology Platform, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy. |
| Source: | Cancers [Cancers (Basel)] 2020 Apr 09; Vol. 12 (4). Date of Electronic Publication: 2020 Apr 09. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI |
| Abstract: | Distant metastases (DM) in head and neck squamous cell carcinoma (HNSCC) remain a challenge as treatment options are limited. To identify biomarkers predictive of DM in primary tumors (PT), gene expression profiling was performed in PT from patients who did, or did not develop DM (T-with and T-without, n = 25 and 24, respectively), and in matched DM. A total of 185 and 42 differentially expressed genes were identified in the T-with vs. T-without and the T-with vs. DM comparisons, respectively. The intersection between these two comparisons identified COX7A1 and TBX5 as common genes. In three independent datasets, both genes were able to significantly distinguish patients according to their DM-free survival. By functional biological analyses, the T-without group showed enrichment in immune-response pathways, whereas the T-with group showed an enrichment in B-plasma cells and Tregs. Increased enrichment of proliferation-related pathways was observed in the T-with group compared with that in the DM group. Further comparisons with/without DM are needed to confirm these data in order to improve clinical management of HNSCC. |
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| Grant Information: | ID 23573 Associazione Italiana per la Ricerca sul Cancro |
| Contributed Indexing: | Keywords: biomarkers; distant metastases; gene expression profiling; head and neck squamous cell carcinoma |
| Entry Date(s): | Date Created: 20200415 Latest Revision: 20200928 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC7225924 |
| DOI: | 10.3390/cancers12040922 |
| PMID: | 32283719 |
| Database: | MEDLINE |
Journal Article