[Frequency and titration of hemolytic activity of anti-A and anti-B antibodies in mothers of children with jaundice in Yaoundé, Cameroon].
| Title: | [Frequency and titration of hemolytic activity of anti-A and anti-B antibodies in mothers of children with jaundice in Yaoundé, Cameroon]. |
|---|---|
| Transliterated Title: | Fréquence et titrage des hémolysines anti-A et anti-B chez les mères d’enfants ictériques à Yaoundé, Cameroun. |
| Authors: | Sock DS; Ecole des Sciences de la Santé, Université Catholique d'Afrique Centrale, Yaoundé, Cameroun.; Molecular Diagnostic Research Group, the Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Kamdem SD; Ecole des Sciences de la Santé, Université Catholique d'Afrique Centrale, Yaoundé, Cameroun.; Molecular Diagnostic Research Group, the Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Boula A; Centre Mère et Enfant de la Fondation Chantal Biya, Yaoundé Cameroun.; Netongo PM; Molecular Diagnostic Research Group, the Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Département de Biochimie, Université de Yaoundé, Yaoundé, Cameroun. |
| Source: | The Pan African medical journal [Pan Afr Med J] 2020 Jan 15; Vol. 35, pp. 13. Date of Electronic Publication: 2020 Jan 15 (Print Publication: 2020). |
| Publication Type: | Journal Article |
| Language: | French |
| Journal Info: | Publisher: African Field Epidemiology Network Country of Publication: Uganda NLM ID: 101517926 Publication Model: eCollection Cited Medium: Internet ISSN: 1937-8688 (Electronic) NLM ISO Abbreviation: Pan Afr Med J Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Kampala, Uganda : African Field Epidemiology Network |
| MeSH Terms: | Jaundice, Neonatal*/blood ; Jaundice, Neonatal*/diagnosis ; Jaundice, Neonatal*/epidemiology ; Mothers*/statistics & numerical data; ABO Blood-Group System/*immunology ; Autoantibodies/*analysis ; Complement Hemolytic Activity Assay/*statistics & numerical data; Autoantibodies/blood ; Blood Group Incompatibility/blood ; Blood Group Incompatibility/diagnosis ; Blood Group Incompatibility/epidemiology ; Cameroon/epidemiology ; Adolescent ; Adult ; Cross-Sectional Studies ; Female ; Hemolysis ; Humans ; Infant, Newborn ; Male ; Prevalence ; Young Adult |
| Abstract: | Introduction: The alloimmunization of the ABO blood group system is involved in neonatal jaundice with a considerable overall prevalence. The role of ABO incompatibility is relatively little known. The purpose of this study was to investigate neonatal jaundice due to feto-maternal ABO incompatibilities and to determine the link between the hemolysins value in the mother and the degree of jaundice observed in the infant.; Methods: We conducted a cross-sectional study from June to November 2015. The study population was exclusively composed of moms who were blood type O with children who were a different blood type hospitalized in the Department of Neonatology at the Reference Hospital in the city of Yaoundé. Statistical analyses were performed using the GraphPadPrism 6 software with a confidence interval of 95%.; Results: Hemolysins frequency was of 20.58% (7/34) and anti-A hemolysin was the most common type (85.7%; 6/7). The new-born who had blood type B had a greater concentration of bilirubin levels compared to those of the AB group (p = 0.01). Multiparity was not associated with the presence of hemolysin (p = 0.8) as well as blood type of the infant was not associated with the occurrence of the hemolysins in the mother (p = 0.5).; Conclusion: Early neonatal jaundice or protracted neonatal jaundice are also caused by hemolysins anti-A and anti-B derived from the allo-ABO immunization. A study on a larger sample is recommended for better assessment.; (© David Sock Sock et al.) |
| Competing Interests: | Les auteurs ne déclarent aucun conflit d’intérêts. |
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| Contributed Indexing: | Keywords: ABO system; Anti-A and anti-B hemolysins; feto-maternal incompatibility; neonatal jaundice |
| Substance Nomenclature: | 0 (ABO Blood-Group System); 0 (Autoantibodies) |
| Entry Date(s): | Date Created: 20200429 Date Completed: 20201207 Latest Revision: 20220414 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC7170741 |
| DOI: | 10.11604/pamj.2020.35.13.14770 |
| PMID: | 32341734 |
| Database: | MEDLINE |
Journal Article