Increased Susceptibility of Cattle to Intranasal RVFV Infection.
| Title: | Increased Susceptibility of Cattle to Intranasal RVFV Infection. |
|---|---|
| Authors: | Kroeker AL; Canadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, MB, Canada.; Smid V; Canadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, MB, Canada.; Embury-Hyatt C; Canadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, MB, Canada.; Collignon B; Canadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, MB, Canada.; Pinette M; Canadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, MB, Canada.; Babiuk S; Canadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, MB, Canada.; Department of Immunology, University of Manitoba, Winnipeg, MB, Canada.; Pickering B; Canadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, MB, Canada.; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.; College of Veterinary Medicine, Iowa State University, Ames, IA, United States. |
| Source: | Frontiers in veterinary science [Front Vet Sci] 2020 Apr 29; Vol. 7, pp. 137. Date of Electronic Publication: 2020 Apr 29 (Print Publication: 2020). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101666658 Publication Model: eCollection Cited Medium: Print ISSN: 2297-1769 (Print) Linking ISSN: 22971769 NLM ISO Abbreviation: Front Vet Sci Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Lausanne : Frontiers Media S.A., [2014]- |
| Abstract: | Rift Valley Fever virus (RVFV) is a zoonotic mosquito-borne virus that belongs to the Phenuiviridae family. Infections in animal herds cause abortion storms, high mortality rates in neonates, and mild to severe symptoms. Infected animals can also transmit the virus to people, particularly people who live or work in close contact with livestock. There is currently an ongoing effort to produce safe and efficacious veterinary vaccines against RVFV in livestock to protect against both primary infection in animals and zoonotic infections in people. To test the efficacy of these vaccines it is essential to have a reliable challenge model in relevant target species, including ruminants. In this study we evaluated three routes of inoculation (intranasal, intradermal and a combination of routes) in Holstein cattle using an infectious dose of 107 pfu/ml and a virus strain from the 2006-2007 outbreak in Kenya and Sudan. Our results demonstrated that all routes of inoculation were effective at producing viremia in all animals; however, the intranasal route induced the highest levels and longest duration of viremia, the most noticeable clinical signs, and the most widespread infection of tissues. We therefore recommend using the intranasal inoculation for future vaccine and challenge studies.; (Copyright © 2020 Kroeker, Smid, Embury-Hyatt, Collignon, Pinette, Babiuk and Pickering.) |
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| Contributed Indexing: | Keywords: Phenuiviridae; Rift Valley Fever; animal model; cattle; virus |
| Entry Date(s): | Date Created: 20200516 Latest Revision: 20200928 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC7200984 |
| DOI: | 10.3389/fvets.2020.00137 |
| PMID: | 32411730 |
| Database: | MEDLINE |
Journal Article