Tubal flushing with oil-based or water-based contrast at hysterosalpingography for infertility: long-term reproductive outcomes of a randomized trial.
| Title: | Tubal flushing with oil-based or water-based contrast at hysterosalpingography for infertility: long-term reproductive outcomes of a randomized trial. |
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| Authors: | van Rijswijk J; Department of Reproductive Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address: j.vanrijswijk@amsterdamumc.nl.; van Welie N; Department of Reproductive Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Dreyer K; Department of Reproductive Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Pham CT; College of Medicine and Public Health, Flinders University, Adelaide, Victoria, Australia.; Verhoeve HR; Department of Obstetrics and Gynaecology, Onze Lieve Vrouwe Gasthuis, Amsterdam; the Netherlands.; Hoek A; Department of Reproductive Medicine and Gynaecology, University of Groningen, University Medical Centre Groningen, Hanzeplein, the Netherlands.; de Bruin JP; Department of Obstetrics and Gynaecology, Jeroen Bosch Hospital, Hertogenbosch, the Netherlands.; Nap AW; Department of Obstetrics and Gynaecology, Rijnstate Hospital, Arnhem, the Netherlands.; van Hooff MHA; Department of Obstetrics and Gynaecology, Franciscus Hospital, Rotterdam, the Netherlands.; Goddijn M; Centre for Reproductive Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Hooker AB; Department of Obstetrics and Gynaecology, Zaans Medical Centre, Zaandam, the Netherlands.; Bourdrez P; Department of Obstetrics and Gynaecology, VieCuri Medical Centre, Venlo, the Netherlands.; van Dongen AJCM; Department of Obstetrics and Gynaecology, Hospital Gelderse Vallei, Ede, the Netherlands.; van Rooij IAJ; Department of Obstetrics and Gynaecology, Elisabeth-TweeSteden Hospital, Tilburg, the Netherlands.; van Rijnsaardt-Lukassen HGM; Department of Obstetrics and Gynaecology, Albert Schweitzer Hospital, Dordrecht, the Netherlands.; van Golde RJT; Department of Obstetrics and Gynaecology, Maastricht UMC, Maastricht, the Netherlands.; van Heteren CF; Department of Obstetrics and Gynaecology, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands.; Pelinck MJ; Department of Obstetrics and Gynaecology, Scheper Hospital, Emmen, the Netherlands.; Duijn AEJ; Vrouwenkliniek Zuidoost, Amsterdam, the Netherlands.; Kaplan M; Department of Obstetrics and Gynaecology, Röpcke-Zweers Hospital, Hardenberg, the Netherlands.; Lambalk CB; Department of Reproductive Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Mijatovic V; Department of Reproductive Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Mol BWJ; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia. |
| Source: | Fertility and sterility [Fertil Steril] 2020 Jul; Vol. 114 (1), pp. 155-162. Date of Electronic Publication: 2020 Jun 16. |
| Publication Type: | Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Elsevier for the American Society for Reproductive Medicine Country of Publication: United States NLM ID: 0372772 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-5653 (Electronic) Linking ISSN: 00150282 NLM ISO Abbreviation: Fertil Steril Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York. NY : Elsevier for the American Society for Reproductive Medicine; Original Publication: New York, Hoeber. |
| MeSH Terms: | Hysterosalpingography*/adverse effects ; Therapeutic Irrigation*/adverse effects ; Fertility*; Contrast Media/*administration & dosage ; Infertility, Female/*diagnostic imaging ; Infertility, Female/*therapy; Contrast Media/adverse effects ; Infertility, Female/physiopathology ; Adolescent ; Adult ; Female ; Humans ; Live Birth ; Netherlands ; Predictive Value of Tests ; Pregnancy ; Pregnancy Rate ; Reproductive Techniques, Assisted ; Time Factors ; Time-to-Pregnancy ; Treatment Outcome ; Young Adult |
| Abstract: | Objective: To determine the impact of oil-based versus water-based contrast on pregnancy and live birth rates ≤5 years after hysterosalpingography (HSG) in infertile women.; Design: A 5-year follow-up study of a multicenter randomized trial.; Setting: Hospitals.; Patient(s): Infertile women with an ovulatory cycle, 18-39 years of age, and having a low risk of tubal pathology.; Intervention(s): Use of oil-based versus water-based contrast during HSG.; Main Outcome Measure(s): Ongoing pregnancy, live births, time to ongoing pregnancy, second ongoing pregnancy.; Result(s): A total of 1,119 women were randomly assigned to HSG with oil-based contrast (n = 557) or water-based contrast (n = 562). After 5 years, 444 of 555 women in the oil group (80.0%) and 419 of 559 women in the water group (75.0%) had an ongoing pregnancy (relative risk [RR] 1.07; 95% confidence interval [CI] 1.00-1.14), and 415 of 555 women in the oil group (74.8%) and 376 of 559 women in the water group (67.3%) had live births (RR 1.11; 95% CI 1.03-1.20). In the oil group, 228 pregnancies (41.1%) were conceived naturally versus 194 (34.7%) pregnancies in the water group (RR 1.18; 95% CI 1.02-1.38). The time to ongoing pregnancy was significantly shorter in the oil group versus the water group (10.0 vs. 13.7 months; hazard ratio, 1.25; 95% CI 1.09-1.43). No difference was found in the occurrence of a second ongoing pregnancy.; Conclusion(s): During a 5-year time frame, ongoing pregnancy and live birth rates are higher after tubal flushing with oil-based contrast during HSG compared with water-based contrast. More pregnancies are naturally conceived and time to ongoing pregnancy is shorter after HSG with oil-based contrast.; Clinical Trial Registration Number: Netherlands Trial Register (NTR) 3270 and NTR6577(www.trialregister.nl).; (Copyright © 2020 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.) |
| Comments: | Comment in: Fertil Steril. 2020 Jul;114(1):75-76. doi: 10.1016/j.fertnstert.2020.04.034.. (PMID: 32532493) |
| Contributed Indexing: | Keywords: Female infertility; hysterosalpingography; oil-based contrast medium; ongoing pregnancy; water-based contrast medium |
| Molecular Sequence: | NTR NTR3270; NTR6577 |
| Substance Nomenclature: | 0 (Contrast Media) |
| Entry Date(s): | Date Created: 20200620 Date Completed: 20210420 Latest Revision: 20210420 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.fertnstert.2020.03.022 |
| PMID: | 32553471 |
| Database: | MEDLINE |
Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't