Effect of nitazoxanide on diarrhea: A systematic review and network meta-analysis of randomized controlled trials.
| Title: | Effect of nitazoxanide on diarrhea: A systematic review and network meta-analysis of randomized controlled trials. |
|---|---|
| Authors: | Hashan MR; Infectious Disease Division, Respiratory and Enteric Infections Department, International Center for Diarrheal Disease Research, Dhaka, Bangladesh; Online Research Club (http://www.onlineresearchclub.org/), Nagasaki, Japan. Electronic address: hasandmck66@gmail.com.; Elhusseiny KM; Online Research Club (http://www.onlineresearchclub.org/), Nagasaki, Japan; Faculty of Medicine, Al-Azhar University, Cairo, Egypt. Electronic address: khaledelhosiny8@gmail.com.; Huu-Hoai L; Online Research Club (http://www.onlineresearchclub.org/), Nagasaki, Japan; Saigon General Hospital, Ho Chi Minh City, Vietnam; University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh, Vietnam. Electronic address: huuhoai.md@gmail.com.; Tieu TM; Online Research Club (http://www.onlineresearchclub.org/), Nagasaki, Japan; Faculty of Health Sciences, McMaster University, Hamilton, ON. Canada. Electronic address: tieut@mcmaster.ca.; Low SK; Online Research Club (http://www.onlineresearchclub.org/), Nagasaki, Japan; School of Medicine, Faculty of Health and Medical Sciences, Taylor's University, Selangor, Malaysia. Electronic address: soonkhai.low@gmail.com.; Minh LHN; Online Research Club (http://www.onlineresearchclub.org/), Nagasaki, Japan; Saigon General Hospital, Ho Chi Minh City, Vietnam. Electronic address: lehuunhatminh.md@ump.edu.vn.; Nghia TLB; Online Research Club (http://www.onlineresearchclub.org/), Nagasaki, Japan; Department of Biomedical Engineering, South Dakota School of Mines and Technology, Rapid City, 57701, United States. Electronic address: banghia0905@gmail.com.; Loc LQ; Online Research Club (http://www.onlineresearchclub.org/), Nagasaki, Japan; Saigon General Hospital, Ho Chi Minh City, Vietnam. Electronic address: lequangloc.md@gmail.com.; Y MN; Online Research Club (http://www.onlineresearchclub.org/), Nagasaki, Japan; Department of Chemical and Biological Engineering, South Dakota School of Mines and Technology, Rapid City, 57701, United States. Electronic address: vivianmai1993@gmail.com.; Eid PS; Online Research Club (http://www.onlineresearchclub.org/), Nagasaki, Japan; Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: petersamuel86@gmail.com.; Abed M; Online Research Club (http://www.onlineresearchclub.org/), Nagasaki, Japan; Institute of Medical Technology, Baghdad, Iraq. Electronic address: drabedmn@gmail.com.; Elkolaly SS; Online Research Club (http://www.onlineresearchclub.org/), Nagasaki, Japan; Faculty of Medicine, Menoufia University, Yassin Abdel-ghaffar Street, Shebin El-Kom, Menoufia, 32511, Egypt. Electronic address: salma.said56.ss@gmail.com.; Tawfik GM; Online Research Club (http://www.onlineresearchclub.org/), Nagasaki, Japan; Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: dr.gehadmohamed@hotmail.com.; Huy NT; Evidence Based Medicine Research Group, Ton Duc Thang University, Ho Chi Minh City, 70000, Vietnam; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, 70000, Vietnam. Electronic address: nguyentienhuy@tdtu.edu.vn. |
| Source: | Acta tropica [Acta Trop] 2020 Oct; Vol. 210, pp. 105603. Date of Electronic Publication: 2020 Jun 26. |
| Publication Type: | Journal Article; Network Meta-Analysis; Systematic Review |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6254 (Electronic) Linking ISSN: 0001706X NLM ISO Abbreviation: Acta Trop Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Elsevier; Original Publication: Basel. |
| MeSH Terms: | Diarrhea*/drug therapy ; Diarrhea*/etiology ; Thiazoles*/adverse effects ; Thiazoles*/therapeutic use; Clostridium Infections/complications ; Clostridium Infections/drug therapy ; Cryptosporidiosis/drug therapy ; Entamoebiasis/complications ; Entamoebiasis/drug therapy ; Giardiasis/complications ; Giardiasis/drug therapy ; Animals ; Humans ; Giardia lamblia ; Nitro Compounds |
| Abstract: | We aimed to systematically review evidence pertaining to the safety and efficacy of nitazoxanide in treating infectious diarrhea. On September 21, 2017, we identified relevant studies using 12 databases. The estimates of the included studies were pooled as a risk ratio (RR). We conducted a network and pairwise random-effects meta-analysis for both direct and indirect comparisons of different organisms that are known to cause diarrhea. The primary and secondary analysis outcomes were clinical response until cessation of illness, parasitological response and adverse events. We included 18 studies in our analysis. In cryptosporidiosis, the overall estimate favored nitazoxanide in its clinical response in comparison with placebo RR 1.46 [95% CI 1.22-1.74; P-value |
| Contributed Indexing: | Keywords: Antibiotic; Diarrhea; Meta-analysis; Nitazoxanide; Systematic review |
| Substance Nomenclature: | SOA12P041N (nitazoxanide); 0 (Nitro Compounds); 0 (Thiazoles) |
| Entry Date(s): | Date Created: 20200630 Date Completed: 20210107 Latest Revision: 20250710 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.actatropica.2020.105603 |
| PMID: | 32598920 |
| Database: | MEDLINE |
Journal Article; Network Meta-Analysis; Systematic Review