Antipsychotic treatment experiences of people with bipolar I disorder: patient perspectives from an online survey.
| Title: | Antipsychotic treatment experiences of people with bipolar I disorder: patient perspectives from an online survey. |
|---|---|
| Authors: | Bessonova L; Alkermes, Inc., 852 Winter Street, Waltham, MA, USA. Leona.Bessonova@alkermes.com.; Velligan DI; The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, USA.; Weiden PJ; Alkermes, Inc., 852 Winter Street, Waltham, MA, USA.; O'Sullivan AK; Alkermes, Inc., 852 Winter Street, Waltham, MA, USA.; Yarlas A; Optum, 1301 Atwood Avenue, Johnston, RI, USA.; Bayliss M; Optum, 1301 Atwood Avenue, Johnston, RI, USA.; Baranwal N; Optum, 1301 Atwood Avenue, Johnston, RI, USA.; Rychlec K; Optum, 1301 Atwood Avenue, Johnston, RI, USA.; Carpenter-Conlin J; Alkermes, Inc., 852 Winter Street, Waltham, MA, USA.; Doane MJ; Alkermes, Inc., 852 Winter Street, Waltham, MA, USA.; Sajatovic M; University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH, USA. |
| Source: | BMC psychiatry [BMC Psychiatry] 2020 Jul 06; Vol. 20 (1), pp. 354. Date of Electronic Publication: 2020 Jul 06. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968559 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-244X (Electronic) Linking ISSN: 1471244X NLM ISO Abbreviation: BMC Psychiatry Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2001- |
| MeSH Terms: | Antipsychotic Agents*/adverse effects ; Bipolar Disorder*/drug therapy; Adult ; Cross-Sectional Studies ; Female ; Humans ; Male ; Surveys and Questionnaires ; Weight Gain |
| Abstract: | Background: Oral antipsychotic (AP) medications are frequently prescribed to people with bipolar I disorder (BD-I). A cross-sectional online survey examined the experiences of people living with BD-I with a history of recent AP use.; Methods: Adults with self-reported physician-diagnosed BD-I (N = 200) who received oral APs during the prior year completed a survey on AP-related experiences, including side effects and their perceived burden on social functioning, adherence, and work. Items also assessed preferences for trade-offs (balancing symptom management and side effects) when considering a hypothetical new AP. The perceived impact of specific, prevalent side effects on adherence, work, and preferences for a hypothetical AP were also examined. Analyses were descriptive.; Results: The survey sample had a mean age of 43.2 (SD = 12.4) years, was 60% female, and 31% nonwhite. Almost all participants (98%) had experienced AP side effects. Common self-reported side effects were feeling drowsy or tired (83%), lack of emotion (79%), anxiety (79%), dry mouth (76%), and weight gain (76%). Weight gain was cited as the most bothersome side effect, rated by most participants (68%) as "very" or "extremely bothersome." Nearly half of participants (49%) reported that AP side effects negatively impacted their job performance; almost all (92%) reported that side effects - most commonly anxiety and lack of emotion - negatively impacted social relationships (e.g., family or romantic partners). The most commonly-reported reason for stopping AP use was dislike of side effects (48%). Side effects most likely to lead to stopping or taking less of AP treatment included "feeling like a 'zombie'" (29%), feeling drowsy or tired (25%), and weight gain (24%). When considering a hypothetical new AP, the most common side effects participants wanted to avoid included AP-induced anxiety (50%), weight gain (48%), and "feeling like a 'zombie'" (47%).; Conclusions: Side effects of APs were both common and bothersome, and impacted social functioning, adherence, and work. Findings highlight the prevailing unmet need for new APs with more favorable benefit-risk profiles. |
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| Contributed Indexing: | Keywords: Adherence; Antipsychotic; Bipolar I disorder; Bipolar disorder; Preference; Side effects |
| Substance Nomenclature: | 0 (Antipsychotic Agents) |
| Entry Date(s): | Date Created: 20200708 Date Completed: 20201221 Latest Revision: 20201221 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC7371473 |
| DOI: | 10.1186/s12888-020-02767-x |
| PMID: | 32631362 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't