Postendodontic Pain after Pulpotomy or Root Canal Treatment in Mature Teeth with Carious Pulp Exposure: A Multicenter Randomized Controlled Trial.
| Title: | Postendodontic Pain after Pulpotomy or Root Canal Treatment in Mature Teeth with Carious Pulp Exposure: A Multicenter Randomized Controlled Trial. |
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| Authors: | Eghbal MJ; Iranian Center for Endodontic Research, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.; Haeri A; Iranian Center for Endodontic Research, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.; Shahravan A; Endodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran.; Kazemi A; Endodontic Department, Dental School, Shahed University, Tehran 1417755351, Iran.; Moazami F; Endodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran.; Mozayeni MA; Endodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.; Saberi E; Endodontic Department, Oral and Dental Diseases Research Center, Dental School, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran.; Samiei M; Endodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran.; Vatanpour M; Endodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran.; Akbarzade Baghban A; Department of Basic Sciences, Proteomics Research Center, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran 1616913111, Iran.; Fazlyab M; Endodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran.; Parhizkar A; Iranian Center for Endodontic Research, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.; Ahmadi M; Endodontic Department, Oral and Dental Diseases Research Center, Dental School, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran.; Akbarian Rad N; Endodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.; Bijari S; Endodontic Department, Oral and Dental Diseases Research Center, Dental School, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran.; Bineshmarvasti D; Endodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran.; Davoudi P; Endodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran.; Dehghan R; Endodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran.; Dehghani M; Endodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran.; Ebrahimi H; Endodontic Department, Oral and Dental Diseases Research Center, Dental School, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran.; Emami N; Endodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran.; Farajian N; Endodontic Department, Dental School, Shahed University, Tehran 1417755351, Iran.; Fereidooni R; Endodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran.; Ghobadi G; Endodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran.; Ghodrati M; Endodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran.; Gohari A; Endodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.; Hashemi A; Endodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran.; Hosseini M; Endodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.; Karami E; Endodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran.; Kheirabadi N; Endodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran.; Kozegari S; Endodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran.; Labaf Ghasemi H; Endodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran.; Majidi A; Endodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran.; Malekzadeh P; Endodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran.; Mehrabi V; Endodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran.; Mohammadi M; Endodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran.; Moradi Eslami L; Endodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran.; Noghani A; Endodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran.; Omatali N; Endodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran.; Pourhatami N; Endodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran.; Rahbani Nobar B; Endodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.; Rahmani S; Endodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran.; Shafaq P; Endodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.; Soofiabadi S; Endodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran.; Teimoori S; Endodontic Department, Dental School, Shahed University, Tehran 1417755351, Iran.; Vatandoost F; Endodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.; Asgary S; Iranian Center for Endodontic Research, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran. |
| Source: | Pain research & management [Pain Res Manag] 2020 Jun 30; Vol. 2020, pp. 5853412. Date of Electronic Publication: 2020 Jun 30 (Print Publication: 2020). |
| Publication Type: | Journal Article; Multicenter Study; Randomized Controlled Trial; Equivalence Trial |
| Language: | English |
| Journal Info: | Publisher: Hindawi Publishing Corporation Country of Publication: United States NLM ID: 9612504 Publication Model: eCollection Cited Medium: Internet ISSN: 1918-1523 (Electronic) Linking ISSN: 12036765 NLM ISO Abbreviation: Pain Res Manag Subsets: MEDLINE |
| Imprint Name(s): | Publication: : New York, NY : Hindawi Publishing Corporation; Original Publication: Oakville, Ont. : Pulsus Group, 1996- |
| MeSH Terms: | Postoperative Pain/*etiology ; Pulpotomy/*methods ; Root Canal Filling Materials/*therapeutic use ; Root Canal Therapy/*methods; Aluminum Compounds/therapeutic use ; Calcium Compounds/therapeutic use ; Dental Cements/therapeutic use ; Oxides/therapeutic use ; Postoperative Pain/epidemiology ; Pulpotomy/adverse effects ; Root Canal Therapy/adverse effects ; Silicates/therapeutic use ; Adult ; Drug Combinations ; Female ; Humans ; Male ; Molar ; Prevalence ; Treatment Outcome |
| Abstract: | This equivalence, randomized, clinical trial aimed to compare the postoperative pain of root canal therapy (RCT) with pulpotomy with mineral trioxide aggregate (PMTA) or calcium-enriched mixture (PCEM) in permanent mature teeth. In seven academic centers, 550 cariously exposed pulps were included and randomly allocated into PMTA (n = 188), PCEM (n = 194), or RCT (n = 168) arms. Preoperative "Pain Intensity" (PI) on Numerical Rating Scale and postoperative PIs until day 7 were recorded. Patients' demographic and pre-/intra-/postoperative factors/conditions were recorded/analysed. The arms were homogeneous in terms of demographics. The mean preoperative PIs were similar (P=0.998), the mean sum PIs recorded during 10 postoperative intervals were comparable (P=0.939), and the trend/changes in pain relief were parallel (P=0.821) in all study arms. The incidences of preoperative moderate-severe pain in RCT, PMTA, and PCEM arms were 56.5%, 55.7%, and 56.7%, which after 24 hours considerably decreased to 13.1%, 10.6%, and 12.9%, respectively (P=0.578). The time span of endodontic procedures was statistically different; RCT = 69.73, PMTA = 35.37, and PCEM = 33.62 minutes (P < 0.001). Patients with greater preoperative pain, symptomatic apical periodontitis, or presence of PDL widening suffered more pain (P=0.002, 0.035, and 0.023, resp.); however, other pre-/intra-/postoperative factors/conditions were comparable. Pulpotomy with MTA/CEM and RCT demonstrate comparable and effective postoperative pain relief.; (Copyright © 2020 Mohammad Jafar Eghbal et al.) |
| Competing Interests: | Saeed Asgary is the inventor of CEM cement (Endodontic Filling Material, USA, 7,942,961, 17 May, 2011). All other authors declare that there are no conflicts of interest regarding the publication of this paper. |
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| Substance Nomenclature: | 0 (Aluminum Compounds); 0 (Calcium Compounds); 0 (Dental Cements); 0 (Drug Combinations); 0 (Oxides); 0 (Root Canal Filling Materials); 0 (Silicates); 0 (mineral trioxide aggregate) |
| Entry Date(s): | Date Created: 20200718 Date Completed: 20201123 Latest Revision: 20260120 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC7345601 |
| DOI: | 10.1155/2020/5853412 |
| PMID: | 32676136 |
| Database: | MEDLINE |
Journal Article; Multicenter Study; Randomized Controlled Trial; Equivalence Trial