Automated vs. conventional ventilation in the ICU: a randomized controlled crossover trial comparing blood oxygen saturation during daily nursing procedures (I-NURSING).
| Title: | Automated vs. conventional ventilation in the ICU: a randomized controlled crossover trial comparing blood oxygen saturation during daily nursing procedures (I-NURSING). |
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| Authors: | Chelly J; Intensive Care Unit, Groupe Hospitalier Sud Ile de France, 270 avenue Marc Jacquet, 77000, Melun, France. jonathanchelly1@gmail.com.; Clinical Research Unit, Groupe Hospitalier Sud Ile de France, 270 avenue Marc Jacquet, 77000, Melun, France. jonathanchelly1@gmail.com.; Mazerand S; Intensive Care Unit, Groupe Hospitalier Sud Ile de France, 270 avenue Marc Jacquet, 77000, Melun, France.; Jochmans S; Intensive Care Unit, Groupe Hospitalier Sud Ile de France, 270 avenue Marc Jacquet, 77000, Melun, France.; Clinical Research Unit, Groupe Hospitalier Sud Ile de France, 270 avenue Marc Jacquet, 77000, Melun, France.; Weyer CM; Intensive Care Unit, Groupe Hospitalier Sud Ile de France, 270 avenue Marc Jacquet, 77000, Melun, France.; Pourcine F; Intensive Care Unit, Groupe Hospitalier Sud Ile de France, 270 avenue Marc Jacquet, 77000, Melun, France.; Ellrodt O; Intensive Care Unit, Groupe Hospitalier Sud Ile de France, 270 avenue Marc Jacquet, 77000, Melun, France.; Thieulot-Rolin N; Intensive Care Unit, Groupe Hospitalier Sud Ile de France, 270 avenue Marc Jacquet, 77000, Melun, France.; Serbource-Goguel J; Intensive Care Unit, Groupe Hospitalier Sud Ile de France, 270 avenue Marc Jacquet, 77000, Melun, France.; Sy O; Intensive Care Unit, Groupe Hospitalier Sud Ile de France, 270 avenue Marc Jacquet, 77000, Melun, France.; Vong LVP; Intensive Care Unit, Groupe Hospitalier Sud Ile de France, 270 avenue Marc Jacquet, 77000, Melun, France.; Monchi M; Intensive Care Unit, Groupe Hospitalier Sud Ile de France, 270 avenue Marc Jacquet, 77000, Melun, France.; Clinical Research Unit, Groupe Hospitalier Sud Ile de France, 270 avenue Marc Jacquet, 77000, Melun, France. |
| Source: | Critical care (London, England) [Crit Care] 2020 Jul 22; Vol. 24 (1), pp. 453. Date of Electronic Publication: 2020 Jul 22. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 9801902 Publication Model: Electronic Cited Medium: Internet ISSN: 1466-609X (Electronic) Linking ISSN: 13648535 NLM ISO Abbreviation: Crit Care Subsets: MEDLINE |
| Imprint Name(s): | Publication: London, UK : BioMed Central Ltd; Original Publication: London : Current Science Ltd, c1997- |
| MeSH Terms: | Monitoring, Physiologic/*statistics & numerical data ; Oxygen/*analysis ; Respiration, Artificial/*methods ; Respiration, Artificial/*standards; Intensive Care Units/organization & administration ; Intensive Care Units/statistics & numerical data ; Monitoring, Physiologic/methods ; Oximetry/methods ; Oximetry/statistics & numerical data ; Oxygen/blood ; Respiration, Artificial/statistics & numerical data ; Aged ; Aged, 80 and over ; Cross-Over Studies ; Female ; France ; Humans ; Male ; Middle Aged ; Prospective Studies |
| Abstract: | Background: Hypoxia is common during daily nursing procedures (DNPs) routinely performed on mechanically ventilated patients. The impact of automated ventilation on the incidence and severity of blood oxygen desaturation during DNPs remains unknown.; Methods: A prospective randomized controlled crossover trial was carried out in a French intensive care unit to compare blood oxygen pulse saturation (SpO2) during DNPs performed on patients mechanically ventilated in automated and conventional ventilation modes (AV and CV, respectively). All patients with FiO2 ≤ 60% and without prone positioning or neuromuscular blocking agents were included. Patients underwent two DNPs on the same day using AV (INTELLiVENT-ASV®) and CV (volume control, biphasic positive airway pressure, or pressure support ventilation) in a randomized order. The primary outcome was the percentage of time spent with SpO2 in the acceptable range of 90-95% during the DNP.; Results: Of the 265 included patients, 93% had been admitted for a medical pathology, the majority for acute respiratory failure (52%). There was no difference between the two periods in terms of DNP duration, sedation requirements, or ventilation parameters, but patients had more spontaneous breaths and lower peak airway pressures during the AV period (p |
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| Contributed Indexing: | Keywords: Automated ventilation; Mechanical ventilation; Nursing procedure |
| Molecular Sequence: | ClinicalTrials.gov NCT03176329 |
| Substance Nomenclature: | S88TT14065 (Oxygen) |
| Entry Date(s): | Date Created: 20200724 Date Completed: 20210414 Latest Revision: 20210414 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC7374079 |
| DOI: | 10.1186/s13054-020-03155-3 |
| PMID: | 32698860 |
| Database: | MEDLINE |
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't