Risk factors for atopic diseases and recurrent respiratory tract infections in children.
| Title: | Risk factors for atopic diseases and recurrent respiratory tract infections in children. |
|---|---|
| Authors: | Kansen HM; Department of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.; Department of Dermatology/Allergology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.; Lebbink MA; Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.; Mul J; Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.; van Erp FC; Department of Dermatology/Allergology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.; van Engelen M; Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.; de Vries E; Department of Tranzo, Tilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, The Netherlands.; Jeroen Bosch Academy Research, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.; Prevaes SMPJ; Department of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.; Le TM; Department of Dermatology/Allergology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.; van der Ent CK; Department of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.; Verhagen LM; Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands. |
| Source: | Pediatric pulmonology [Pediatr Pulmonol] 2020 Nov; Vol. 55 (11), pp. 3168-3179. Date of Electronic Publication: 2020 Sep 15. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8510590 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0496 (Electronic) Linking ISSN: 10990496 NLM ISO Abbreviation: Pediatr Pulmonol Subsets: MEDLINE |
| Imprint Name(s): | Publication: : Hoboken, NJ : Wiley-Liss; Original Publication: [Philadelphia, PA] : W.B. Saunders, [c1985- |
| MeSH Terms: | Hypersensitivity/*epidemiology ; Respiratory Tract Infections/*epidemiology; Adolescent ; Animals ; Child ; Child, Preschool ; Day Care, Medical ; Dogs ; Female ; Humans ; Infant ; Male ; Odds Ratio ; Pets ; Prevalence ; Recurrence ; Risk Factors |
| Abstract: | Introduction: The simultaneously increased prevalence of atopic diseases and decreased prevalence of infectious diseases might point to a link between the two entities. Past work mainly focused on either atopic diseases or recurrent infections. We aim to investigate whether risk factors for atopic diseases (ie, asthma, allergic rhinitis, atopic dermatitis, and/or food allergy) differ from risk factors for recurrent respiratory tract infections (RRTIs) in children.; Methods: Cross-sectional data were used from 5517 children aged 1 to 18 years who participated in an Electronic Portal for children between 2011 and 2019. Univariable/multivariable logistic regression analyses were performed to determine risk factors for any atopic disease and RRTIs.; Results: Children aged ≥5 years were more likely to have any atopic disease (adjusted odds ratio [OR]: 1.50-2.77) and less likely to have RRTIs (OR: 0.68-0.84) compared to children aged less than 5 years. Female sex (OR: 0.72; 95% confidence interval [CI]: 0.63-0.81), low birth weight (OR: 0.74; 95% CI: 0.57-0.97) and dog ownership (OR: 0.79; 95% CI: 0.66-0.95) reduced the odds of any atopic disease, but not of RRTIs. Daycare attendance (OR: 1.22; 95% CI: 1.02-1.47) was associated with RRTIs, but not with atopic diseases. A family history of asthma, allergic rhinitis, atopic dermatitis, and RRTIs was significantly associated with the same entity in children, with OR varying from 1.58 (95% CI: 1.35-1.85) in allergic rhinitis to 2.20 (95% CI: 1.85-2.61) in asthma.; Conclusion: Risk factors for atopic diseases are distinct from risk factors for RRTIs, suggesting that the changing prevalence of both entities is not related to shared risk factors.; (© 2020 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.) |
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| Contributed Indexing: | Keywords: atopic disease; atopy; children; recurrent infection; respiratory tract infections; risk factors |
| Entry Date(s): | Date Created: 20200826 Date Completed: 20210322 Latest Revision: 20210322 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC7589449 |
| DOI: | 10.1002/ppul.25042 |
| PMID: | 32841506 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't