Increased risk of late-onset, immune-mediated, adverse reactions related to dermal fillers in patients bearing HLA-B*08 and DRB1*03 haplotypes.
| Title: | Increased risk of late-onset, immune-mediated, adverse reactions related to dermal fillers in patients bearing HLA-B*08 and DRB1*03 haplotypes. |
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| Authors: | Decates TS; Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands.; Velthuis PJ; Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands.; Schelke LW; Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands.; Lardy N; Sanquin Diagnostic Services, Amsterdam, The Netherlands.; Palou E; Inmunobiology Laboratory for Research and Diagnostic Applications (LIRAD), Blood and Tissue Bank, Germans Trias i Pujol Research Institute, Barcelona, Spain.; Schwartz S; Aging Basic Research Unit, Molecular Biology and Biochemistry Research Centerfor Nanomedicine (CIBBIM-Nanomedicine), Vall d'Hebron University Research Institute (VHIR), Vall d'Hebron University Hospital, Barcelona, Spain.; Bachour Y; Department of Plastic Surgery, VU University Medical Center, Amsterdam, The Netherlands.; Niessen FB; Department of Plastic Surgery, VU University Medical Center, Amsterdam, The Netherlands.; Nijsten T; Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands.; Alijotas-Reig J; Aging Basic Research Unit, Molecular Biology and Biochemistry Research Centerfor Nanomedicine (CIBBIM-Nanomedicine), Vall d'Hebron University Research Institute (VHIR), Vall d'Hebron University Hospital, Barcelona, Spain.; Department of Medicine, Faculty of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.; Systemic Autoimmune Disease Unit, Department of Medicine, Vall d'Hebron University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain. |
| Source: | Dermatologic therapy [Dermatol Ther] 2021 Jan; Vol. 34 (1), pp. e14644. Date of Electronic Publication: 2020 Dec 19. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 9700070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-8019 (Electronic) Linking ISSN: 13960296 NLM ISO Abbreviation: Dermatol Ther Subsets: MEDLINE |
| Imprint Name(s): | Publication: July/Aug. 2008- : Hoboken, NJ : Wiley-Blackwell; Original Publication: Copenhagen : Munksgaard, c1996- |
| MeSH Terms: | Dermal Fillers/*adverse effects ; HLA-B Antigens/*genetics ; HLA-DRB1 Chains/*genetics; Autoimmune Diseases ; Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Hypersensitivity ; Inflammation ; Male |
| Abstract: | Even though manufacturers claim that the dermal fillers are nontoxic and nonimmunogenic, adverse events may occur. Clinically and histologically, most of the late onset adverse events present as an inflammatory response. To assess whether HLA polymorphisms are associated with late-onset inflammatory adverse events related to dermal fillers. A total of 211 patients were included, of whom 129 experienced late-onset inflammatory adverse events to different fillers (Inflammation group) and 82 who did not (Reference group). Patients completed a standardized questionnaire and provided a blood sample or oral swap for HLA testing. The study population consisted of 188 (89%) women and 23 (11%) men. The two study groups were similar in the distributions of filler type, location of injecting, allergy, autoimmune disease, gender, age, ethnicity, and smoking status. Of the 211 patients in the sample, 25 had the combination of HLA subtype-B*08 and HLA subtype-DRB1*03. This was 16.3% of the inflammatory group and 4.9% of the reference group. This combination of HLA subtypes was associated with an almost 4-fold increase in the odds of developing immune mediated adverse events (odds ratio = 3.79, 95% CI 1.25-11.48). Genetic polymorphisms such as HLA combinations may identify patients at risk of developing late onset immune mediated adverse events to dermal fillers.; (© 2020 Wiley Periodicals LLC.) |
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| Grant Information: | SEMCC (Sociedad Española de Medicina y Cirugía Cosmética -Spanish Society of Cosmetic Medicine&Surgery; Netherlands ZONMW_ ZonMw |
| Contributed Indexing: | Keywords: HLA; adverse reaction; cosmetic dermatology; dermal filler; haplotypes; immunogenetics; late-onset reaction |
| Substance Nomenclature: | 0 (Dermal Fillers); 0 (HLA-B Antigens); 0 (HLA-DRB1 Chains) |
| Entry Date(s): | Date Created: 20201210 Date Completed: 20210524 Latest Revision: 20220531 |
| Update Code: | 20260130 |
| DOI: | 10.1111/dth.14644 |
| PMID: | 33300274 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't