Child buccal telomere length and mitochondrial DNA content as biomolecular markers of ageing in association with air pollution.
| Title: | Child buccal telomere length and mitochondrial DNA content as biomolecular markers of ageing in association with air pollution. |
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| Authors: | Hautekiet P; Centre for Environmental Sciences, Hasselt University, Agoralaan gebouw D, BE-3590 Hasselt, Belgium; Risk and Health Impact Assessment, Sciensano, Juliette Wytsmanstraat 14, BE-1050 Brussels, Belgium.; Nawrot TS; Centre for Environmental Sciences, Hasselt University, Agoralaan gebouw D, BE-3590 Hasselt, Belgium; Department of Public Health & Primary Care, University of Leuven (KU Leuven), O&N I Herestraat 49 - bus 706, BE-3000 Leuven, Belgium. Electronic address: tim.nawrot@uhasselt.be.; Janssen BG; Centre for Environmental Sciences, Hasselt University, Agoralaan gebouw D, BE-3590 Hasselt, Belgium.; Martens DS; Centre for Environmental Sciences, Hasselt University, Agoralaan gebouw D, BE-3590 Hasselt, Belgium.; De Clercq EM; Risk and Health Impact Assessment, Sciensano, Juliette Wytsmanstraat 14, BE-1050 Brussels, Belgium.; Dadvand P; ISGlobal, Campus Mar, Dr Aiguader 88, ES-08003 Barcelona, Spain; Pompeu Fabra University, Doctor Aiguader 80, 08003 Barcelona, Catalonia, Spain; Ciber on Epidemiology and Public Health (CIBERESP), Melchor Fernández Almagro 3-5, 28029 Madrid, Spain.; Plusquin M; Centre for Environmental Sciences, Hasselt University, Agoralaan gebouw D, BE-3590 Hasselt, Belgium.; Bijnens EM; Centre for Environmental Sciences, Hasselt University, Agoralaan gebouw D, BE-3590 Hasselt, Belgium.; Saenen ND; Centre for Environmental Sciences, Hasselt University, Agoralaan gebouw D, BE-3590 Hasselt, Belgium; Risk and Health Impact Assessment, Sciensano, Juliette Wytsmanstraat 14, BE-1050 Brussels, Belgium. |
| Source: | Environment international [Environ Int] 2021 Feb; Vol. 147, pp. 106332. Date of Electronic Publication: 2020 Dec 31. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7807270 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6750 (Electronic) Linking ISSN: 01604120 NLM ISO Abbreviation: Environ Int Subsets: MEDLINE |
| Imprint Name(s): | Publication: : Amsterdam : Elsevier Science; Original Publication: Oxford; Elmsford, N. Y., Pergamon Press. |
| MeSH Terms: | Air Pollutants*/analysis ; Air Pollutants*/toxicity ; Air Pollution*/adverse effects ; Air Pollution*/analysis; DNA, Mitochondrial/genetics ; Environmental Exposure/analysis ; Particulate Matter/analysis ; Particulate Matter/toxicity ; Child ; Humans ; Telomere |
| Abstract: | Background: Pro-inflammatory conditions such as air pollution might induce biological ageing. However, the available evidence on such an impact in children is still very scarce. We studied in primary schoolchildren the association of ambient residential air pollution exposure with telomere length (TL) and mitochondrial DNA content (mtDNAc), two important targets of the core axis of ageing.; Methods: Between 2012 and 2014, buccal TL and mtDNAc were repeatedly assessed using qPCR in 197 Belgian primary schoolchildren (mean age 10.3 years) as part of the COGNAC study. At the child's residence, recent (week), sub-chronic (month) and chronic (year) exposure to nitrogen dioxide (NO2), particulate matter ≤ 2.5 µm (PM2.5) and black carbon (BC) were estimated using a high resolution spatiotemporal model. A mixed-effects model with school and subject as random effect was used while adjusting for a priori chosen covariates.; Results: An interquartile range (IQR) increment (1.9 µg/m3) in chronic PM2.5 exposure was associated with a 8.9% (95% CI: -15.4 to -1.9%) shorter TL. In contrast to PM2.5, chronic exposure to BC and NO2 was not associated with TL but recent exposure to BC and NO2 showed significant inverse associations with TL: an IQR increment in recent exposure to BC (0.9 µg/m3) and NO2 (10.2 µg/m3) was associated with a 6.2% (95% CI: -10.6 to -1.6%) and 6.4% (95% CI: -11.8 to -0.7%) shorter TL, respectively. Finally, an IQR increment in chronic PM2.5 exposure was associated with a 12.7% (95% CI: -21.7 to -2.6%) lower mtDNAc. However, no significant associations were seen for NO2 and BC or for other exposure windows.; Conclusion: Chronic exposure to PM2.5 below the EU threshold was associated with child's shorter buccal TL and lower mtDNAc, while traffic-related pollutants (BC and NO2) showed recent effects on telomere biology. Our data add to the literature on air pollution-induced effects of TL and mtDNAc, two measures part of the core axis of cellular ageing, from early life onwards.; (Copyright © 2020. Published by Elsevier Ltd.) |
| Contributed Indexing: | Keywords: Air pollution; Biological ageing; Biomarkers; Children |
| Substance Nomenclature: | 0 (Air Pollutants); 0 (DNA, Mitochondrial); 0 (Particulate Matter) |
| Entry Date(s): | Date Created: 20210103 Date Completed: 20210423 Latest Revision: 20210423 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.envint.2020.106332 |
| PMID: | 33388564 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't