Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis (1998-2020).
| Title: | Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis (1998-2020). |
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| Authors: | Niba PTN; MARCAD-DELTAS Programme, Laboratory for Public Health Research Biotechnologies, University of Yaoundé I, Yaoundé, Cameroon.; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.; Nji AM; MARCAD-DELTAS Programme, Laboratory for Public Health Research Biotechnologies, University of Yaoundé I, Yaoundé, Cameroon.; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.; Evehe MS; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.; Ali IM; MARCAD-DELTAS Programme, Laboratory for Public Health Research Biotechnologies, University of Yaoundé I, Yaoundé, Cameroon.; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.; Netongo PM; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.; Ngwafor R; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; National Malaria Control Programme, Ministry of Public Health, Yaoundé, Cameroon.; Moyeh MN; MARCAD-DELTAS Programme, Laboratory for Public Health Research Biotechnologies, University of Yaoundé I, Yaoundé, Cameroon.; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea, Cameroon.; Ngum LN; MARCAD-DELTAS Programme, Laboratory for Public Health Research Biotechnologies, University of Yaoundé I, Yaoundé, Cameroon.; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Department of Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.; Institute of Medical Research and Medicinal Plant Studies, Ministry of Scientific Research and Innovation, Yaoundé, Cameroon.; Ndum OE; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Université Des Montagnes, Banganté, West Region, Cameroon.; Acho FA; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Mbu'u CM; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Department of Microbiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.; Fosah DA; National Malaria Control Programme, Ministry of Public Health, Yaoundé, Cameroon.; Atogho-Tiedeu B; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.; Achonduh-Atijegbe O; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Djokam-Dadjeu R; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.; Chedjou JPK; MARCAD-DELTAS Programme, Laboratory for Public Health Research Biotechnologies, University of Yaoundé I, Yaoundé, Cameroon.; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.; Bigoga JD; MARCAD-DELTAS Programme, Laboratory for Public Health Research Biotechnologies, University of Yaoundé I, Yaoundé, Cameroon.; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.; Moukoko CEE; Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon.; Malaria Research Service, Centre Pasteur Cameroon, Yaoundé, Cameroon.; Ajua A; Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea, Cameroon.; Achidi E; Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea, Cameroon.; Tallah E; Malaria Consortium-Cameroon Coalition Against Malaria, Yaoundé, Cameroon.; Leke RGF; MARCAD-DELTAS Programme, Laboratory for Public Health Research Biotechnologies, University of Yaoundé I, Yaoundé, Cameroon.; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon.; Malaria Consortium-Cameroon Coalition Against Malaria, Yaoundé, Cameroon.; Tourgordi A; The Cameroon Office of the World Health Organization, Yaoundé, Cameroon.; Ringwald P; Global Malaria Programme, World Health Organization, Geneva, Switzerland.; Alifrangis M; Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Infectious Diseases, Copenhagen University Hospital, Copenhagen, Denmark.; Mbacham WF; MARCAD-DELTAS Programme, Laboratory for Public Health Research Biotechnologies, University of Yaoundé I, Yaoundé, Cameroon. wfmbacham@yahoo.com.; The Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon. wfmbacham@yahoo.com.; Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon. wfmbacham@yahoo.com.; Malaria Consortium-Cameroon Coalition Against Malaria, Yaoundé, Cameroon. wfmbacham@yahoo.com. |
| Source: | Malaria journal [Malar J] 2021 Jan 09; Vol. 20 (1), pp. 32. Date of Electronic Publication: 2021 Jan 09. |
| Publication Type: | Journal Article; Meta-Analysis; Systematic Review |
| Language: | English |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2002- |
| MeSH Terms: | Polymorphism, Single Nucleotide*; Antimalarials/*pharmacology ; Drug Resistance/*drug effects ; Genetic Markers/*genetics ; Plasmodium falciparum/*genetics; Plasmodium falciparum/drug effects ; Cameroon |
| Abstract: | Background: Malaria remains highly endemic in Cameroon. The rapid emergence and spread of drug resistance was responsible for the change from monotherapies to artemisinin-based combinations. This systematic review and meta-analysis aimed to determine the prevalence and distribution of Plasmodium falciparum drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon from January 1998 to August 2020.; Methods: The PRISMA-P and PRISMA statements were adopted in the inclusion of studies on single nucleotide polymorphisms (SNPs) of P. falciparum anti-malarial drug resistance genes (Pfcrt, Pfmdr1, Pfdhfr, Pfdhps, Pfatp6, Pfcytb and Pfk13). The heterogeneity of the included studies was evaluated using the Cochran's Q and I2 statistics. The random effects model was used as standard in the determination of heterogeneity between studies.; Results: Out of the 902 records screened, 48 studies were included in this aggregated meta-analysis of molecular data. A total of 18,706 SNPs of the anti-malarial drug resistance genes were genotyped from 47,382 samples which yielded a pooled prevalence of 35.4% (95% CI 29.1-42.3%). Between 1998 and 2020, there was significant decline (P |
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| Grant Information: | United Kingdom WT_ Wellcome Trust; 001 International WHO_ World Health Organization; EP-C-15-010 United States EPA EPA |
| Contributed Indexing: | Keywords: Anti-malarial drug; Cameroon; Efficacy; Malaria; Mutations; Plasmodium falciparum; Resistance; Systematic review |
| Substance Nomenclature: | 0 (Antimalarials); 0 (Genetic Markers) |
| Entry Date(s): | Date Created: 20210110 Date Completed: 20210719 Latest Revision: 20250530 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC7796563 |
| DOI: | 10.1186/s12936-020-03543-8 |
| PMID: | 33422080 |
| Database: | MEDLINE |
Journal Article; Meta-Analysis; Systematic Review