DALIA- a comprehensive resource of Disease Alleles in Arab population.
| Title: | DALIA- a comprehensive resource of Disease Alleles in Arab population. |
|---|---|
| Authors: | Vatsyayan A; CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India.; Amity University, Noida, India.; Sharma P; Indraprastha Institute of Information Technology Delhi (IIIT-D), Delhi, India.; Gupta S; Indraprastha Institute of Information Technology Delhi (IIIT-D), Delhi, India.; Sandhu S; Amity University, Rajasthan, Jaipur, India.; Venu SL; ACBR, Delhi, India.; Sharma V; Kalindi College, University of Delhi, New Delhi, India.; Badaoui B; Mohammed V University, Rabat, Morocco.; Azedine K; Mohammed V University, Rabat, Morocco.; Youssef S; Mohammed V University, Rabat, Morocco.; Rajab A; National Genetic Center, Ministry of Health, Muscat, Oman.; Fayez A; Human Genetics and Genome Research Division, Center of Excellence for Human Genetics, National Research Center, Cairo, Egypt.; Madinur S; Independent Researcher, India.; Ranawat A; CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India.; Pandhare K; CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India.; Ramachandran S; CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Sivasubbu S; CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Scaria V; CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India. |
| Source: | PloS one [PLoS One] 2021 Jan 13; Vol. 16 (1), pp. e0244567. Date of Electronic Publication: 2021 Jan 13 (Print Publication: 2021). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: San Francisco, CA : Public Library of Science |
| MeSH Terms: | Alleles* ; Databases, Genetic*; Arabs/*genetics; Familial Mediterranean Fever/genetics ; Hemoglobinopathies/genetics ; Gene Frequency ; Genetic Predisposition to Disease ; Genetic Variation ; Humans |
| Abstract: | The Arab population encompasses over 420 million people characterized by genetic admixture and a consequent rich genetic diversity. A number of genetic diseases have been reported for the first time from the population. Additionally a high prevalence of some genetic diseases including autosomal recessive disorders such as hemoglobinopathies and familial mediterranean fever have been found in the population and across the region. There is a paucity of databases cataloguing genetic variants of clinical relevance from the population. The availability of such a catalog could have implications in precise diagnosis, genetic epidemiology and prevention of disease. To fill in the gap, we have compiled DALIA, a comprehensive compendium of genetic variants reported in literature and implicated in genetic diseases reported from the Arab population. The database aims to act as an effective resource for population-scale and sub-population specific variant analyses, enabling a ready reference aiding clinical interpretation of genetic variants, genetic epidemiology, as well as facilitating rapid screening and a quick reference for evaluating evidence on genetic diseases. |
| Competing Interests: | The authors have declared that no competing interests exist. |
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| Entry Date(s): | Date Created: 20210113 Date Completed: 20210504 Latest Revision: 20210504 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC7806169 |
| DOI: | 10.1371/journal.pone.0244567 |
| PMID: | 33439861 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't