Racial disparities and treatment trends among young-onset colorectal cancer patients: An analysis of a hospital cancer registry.
| Title: | Racial disparities and treatment trends among young-onset colorectal cancer patients: An analysis of a hospital cancer registry. |
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| Authors: | Galadima HI; School of Community and Environmental Health, College of Health Sciences, Old Dominion University, Norfolk, VA, United States. Electronic address: hgaladim@odu.edu.; Adunlin G; Department of Pharmaceutical, Social and Administrative Sciences, Samford University, McWhorter School of Pharmacy, Birmingham, AL, United States.; Hughes MS; Department of Surgery, Eastern Virginia Medical School, Norfolk, VA, United States.; Cropp CD; Department of Pharmaceutical, Social and Administrative Sciences, Samford University, McWhorter School of Pharmacy, Birmingham, AL, United States.; Lucero L; School of Community and Environmental Health, College of Health Sciences, Old Dominion University, Norfolk, VA, United States.; Akpinar-Elci M; Center for Global Health, College of Health Sciences, Old Dominion University, Norfolk, VA, United States. |
| Source: | Cancer epidemiology [Cancer Epidemiol] 2021 Jun; Vol. 72, pp. 101911. Date of Electronic Publication: 2021 Mar 01. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101508793 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1877-783X (Electronic) Linking ISSN: 18777821 NLM ISO Abbreviation: Cancer Epidemiol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier |
| MeSH Terms: | Health Status Disparities*; Colorectal Neoplasms/*ethnology ; Colorectal Neoplasms/*therapy; Adolescent ; Adult ; Age of Onset ; Female ; Hospitals ; Humans ; Male ; Middle Aged ; Registries ; Retrospective Studies ; Virginia ; Young Adult |
| Abstract: | Background: There is an increasing trend of colorectal cancer (CRC) incidence and mortality in individuals under the age of 50. The impact of age on the outcomes of CRC remains controversial. This study examined the characteristics and treatment trends of young-onset CRC by comparing patients < 50 years of age to those ≥50.; Methods: Data were retrospectively obtained from one of the largest hospital systems in Virginia. The sample included patients diagnosed with CRC from 2008 to 2016. Bivariate analyses were used to describe patients' characteristics. Stratified and multivariate analyses were used to evaluate the association between treatments and age groups in different stages at diagnosis.; Results: Approximately 11.6 % (n = 522) of the cohort were younger than 50 years old at diagnosis with a mean age of 42.7 (SD = 5.9) years. Compared to their older counterpart (50 and older), young-onset patients were more likely to be African American (28.7 % (n = 150) vs. 23.7 % (n = 944)), to own private insurance (68.5 % (n = 313) vs. 27.6 % (n = 1032)), to have never used tobacco products (50.4 % (n = 237) vs. 43.8 % (n = 1616)), and to be late stage at diagnosis (68.6 % (n = 358) vs. 52.5 % (n = 2090)) (all p < 0.05). For early stage diagnosis, over 98 % of the young-onset treatments were surgery. For late stage diagnosis, the cancer treatment for young onset patients were a combination of surgery (89.4 %), radiation (82.5 %), and chemotherapy (86.3 %). The results of the analyses also demonstrated that patients with young-onset CRC have higher odds for surgery [OR = 1.76, 95 %CI (1.26, 2.47)], radiation [OR = 1.31, 95 %CI (1.17, 1.47)], and chemotherapy [OR = 3.34, 95 %CI (2.62, 4.25)].; Conclusions: Findings confirmed late-stage prevalence among young-onset as well as significant demographic differences with patients' age ≥50. This study is one of few to explore the characteristics and assess treatment of young patients with CRC using U.S hospital data. Moreover, further studies need to clarify the effects of biological properties like genetic influences and environmental factors between races on cancer patient outcomes.; (Copyright © 2021 Elsevier Ltd. All rights reserved.) |
| Contributed Indexing: | Keywords: Colorectal cancer; Diagnosis; Health disparity; Race; Treatment; Young-onset |
| Entry Date(s): | Date Created: 20210304 Date Completed: 20210707 Latest Revision: 20210707 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.canep.2021.101911 |
| PMID: | 33662693 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't