Effect of Melatonin on Delirium After on-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial.
| Title: | Effect of Melatonin on Delirium After on-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial. |
|---|---|
| Authors: | Javaherforoosh Zadeh F; Department of Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Janatmakan F; Department of Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Shafaeebejestan E; Department of Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Jorairahmadi S; Department of Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. |
| Source: | Iranian journal of medical sciences [Iran J Med Sci] 2021 Mar; Vol. 46 (2), pp. 120-127. |
| Publication Type: | Journal Article; Randomized Controlled Trial |
| Language: | English |
| Journal Info: | Publisher: Shiraz University of Medical Sciences Country of Publication: Iran NLM ID: 8104374 Publication Model: Print Cited Medium: Print ISSN: 0253-0716 (Print) Linking ISSN: 02530716 NLM ISO Abbreviation: Iran J Med Sci |
| Imprint Name(s): | Publication: : Shiraz, Iran : Shiraz University of Medical Sciences; Original Publication: Shiraz, Iran : Shiraz University, Medical School |
| MeSH Terms: | Coronary Artery Bypass/*adverse effects ; Delirium/*drug therapy ; Melatonin/*pharmacology; Coronary Artery Bypass/methods ; Coronary Artery Bypass/psychology ; Delirium/etiology ; Delirium/psychology ; Melatonin/therapeutic use ; Postoperative Complications/drug therapy ; Aged ; Double-Blind Method ; Female ; Humans ; Iran ; Male ; Middle Aged |
| Abstract: | Background: Patients undergoing cardiac surgery are particularly prone to delirium. This study aimed to evaluate the effect of melatonin administration on the inhibition of postoperative delirium in patients undergoing open-heart surgery.; Methods: This study was conducted as a double-blind randomized clinical trial in Golestan Hospital. Ahvaz, Iran, (September 2018 to March 2019). Sixty patients undergoing elective on-pump coronary artery bypass graft surgery were enrolled in the study, and they were randomly divided into a group receiving 3 mg of melatonin and a group receiving a placebo. The main outcomes were delirium occurrence and delirium intensity up to 48 hours after extubation. The data were analyzed using SPSS, version 22, (SPSS, Chicago, IL). Group comparisons were performed using the t test and the Chi-square test. Statistical significance was defined as a P value of less than 0.05.; Results: On the first postoperative day, delirium developed in four (13.3%) patients in the melatonin group and 11 (36.6%) patients in the control group; the difference between the groups was statistically significant (P=0.037). On the second postoperative day, delirium developed in three (10%) patients in the melatonin group and 14 (46.6%) patients in the control group, with the difference in the incidence of delirium between the groups constituting statistical significance (P=0.029). The severity of delirium between group was significant on the first and second postoperative days (P=0.003).; Conclusion: Melatonin may be effective in reducing the severity of delirium after cardiac surgery. The effect of melatonin as a delirium prevention agent should be considered in patients admitted in the cardiovascular intensive care. Trial Registration Number IRCT20180909040979N3.; (Copyright: © Iranian Journal of Medical Sciences.) |
| References: | Int J Geriatr Psychiatry. 2011 Jul;26(7):687-94. (PMID: 20845391); Anesth Pain Med. 2018 Jun 24;8(3):e68763. (PMID: 30214884); J Crit Care. 2010 Mar;25(1):144-51. (PMID: 19828283); J Cardiothorac Vasc Anesth. 2011 Oct;25(5):811-6. (PMID: 20655248); Indian J Psychiatry. 2013 Jul;55(3):220-3. (PMID: 24082241); Anesthesiology. 2010 Oct;113(4):968-76. (PMID: 20823763); Kardiochir Torakochirurgia Pol. 2015 Jun;12(2):126-33. (PMID: 26336494); Indian J Pharmacol. 2013 Nov-Dec;45(6):581-6. (PMID: 24347765); J Clin Anesth. 2020 Feb;59:74-81. (PMID: 31279283); Crit Care Med. 2010 Feb;38(2):419-27. (PMID: 19915454); Trials. 2016 Jan 28;17:55. (PMID: 26822209); Indian J Ophthalmol. 2013 Jul;61(7):319-24. (PMID: 23552356); CMAJ. 2014 Oct 7;186(14):E547-56. (PMID: 25183726); Trials. 2017 Jan 6;18(1):4. (PMID: 28061873); Indian J Crit Care Med. 2018 Mar;22(3):144-149. (PMID: 29657370); Ann Intensive Care. 2012 Dec 27;2(1):49. (PMID: 23270646); Syst Rev. 2016 Dec 7;5(1):211. (PMID: 27923397); Int J Cardiol. 2016 Oct 15;221:977-86. (PMID: 27441478); Semin Cardiothorac Vasc Anesth. 2010 Sep;14(3):212-7. (PMID: 20647262); Crit Care Med. 2015 Mar;43(3):557-66. (PMID: 25493968); Oncologist. 2020 Feb;25(2):e335-e340. (PMID: 32043769); Biomed Res Int. 2013;2013:323491. (PMID: 24102052) |
| Contributed Indexing: | Keywords: Delirium; Melatonin; Thoracic surgery |
| Molecular Sequence: | IRCT IRCT20180909040979N3 |
| Substance Nomenclature: | JL5DK93RCL (Melatonin) |
| Entry Date(s): | Date Created: 20210323 Date Completed: 20211020 Latest Revision: 20211020 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC7966933 |
| DOI: | 10.30476/ijms.2020.82860.1146 |
| PMID: | 33753956 |
| Database: | MEDLINE |
Journal Article; Randomized Controlled Trial