A resource of targeted mutant mouse lines for 5,061 genes.
| Title: | A resource of targeted mutant mouse lines for 5,061 genes. |
|---|---|
| Authors: | Birling MC; Université de Strasbourg, CNRS, INSERM, PHENOMIN-ICS, IGBMC, Illkirch, France.; Yoshiki A; RIKEN BioResource Research Center, Tsukuba, Japan.; Adams DJ; Wellcome Sanger Institute, Hinxton, UK.; Ayabe S; RIKEN BioResource Research Center, Tsukuba, Japan.; Beaudet AL; Baylor College of Medicine, Houston, TX, USA.; Luna Genetics, Houston, TX, USA.; Bottomley J; Wellcome Sanger Institute, Hinxton, UK.; Bradley A; Wellcome Sanger Institute, Hinxton, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Brown SDM; MRC Harwell Institute, Mammalian Genetics Unit, Didcot, UK.; Bürger A; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Bushell W; Wellcome Sanger Institute, Hinxton, UK.; IONTAS, Cambridge, UK.; Chiani F; Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo, Italy.; Chin HG; National Laboratory Animal Center, National Applied Research Laboratories (NARLabs), Taipei, Taiwan.; Christou S; MRC Harwell Institute, Mary Lyon Centre, Didcot, UK.; Codner GF; MRC Harwell Institute, Mary Lyon Centre, Didcot, UK.; DeMayo FJ; Baylor College of Medicine, Houston, TX, USA.; National Institute for Environmental Health Science Research, Durham, NC, USA.; Dickinson ME; Baylor College of Medicine, Houston, TX, USA.; Doe B; Wellcome Sanger Institute, Hinxton, UK.; Donahue LR; The Jackson Laboratory, Bar Harbor, ME, USA.; Fray MD; MRC Harwell Institute, Mary Lyon Centre, Didcot, UK.; Gambadoro A; Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo, Italy.; Gao X; SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, China.; Gertsenstein M; Centre for Phenogenomics, Toronto, Ontario, Canada.; Gomez-Segura A; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.; Goodwin LO; The Jackson Laboratory, Bar Harbor, ME, USA.; Heaney JD; Baylor College of Medicine, Houston, TX, USA.; Hérault Y; Université de Strasbourg, CNRS, INSERM, PHENOMIN-ICS, IGBMC, Illkirch, France.; de Angelis MH; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Experimental Genetics, Center of Life and Food Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany.; German Center for Diabetes Research, Neuherberg, Germany.; Jiang ST; National Laboratory Animal Center, National Applied Research Laboratories (NARLabs), Taipei, Taiwan.; Justice MJ; Baylor College of Medicine, Houston, TX, USA.; Centre for Phenogenomics, Toronto, Ontario, Canada.; Hospital for Sick Children, Toronto, Ontario, Canada.; Kasparek P; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic.; King RE; MRC Harwell Institute, Mammalian Genetics Unit, Didcot, UK.; Kühn R; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Max Delbrueck Center for Molecular Medicine, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany.; Lee H; Korea Mouse Phenotyping Center (KMPC) and Graduate School of Cancer Science and Policy, National Cancer Center, Gyeonggi, Republic of Korea.; Lee YJ; Korea Mouse Phenotyping Center (KMPC) and Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea.; Liu Z; CAM-SU Genomic Resource Center, Soochow University, Suzhou, China.; Lloyd KCK; Mouse Biology Program, University of California, Davis, Davis, CA, USA.; Lorenzo I; Baylor College of Medicine, Houston, TX, USA.; Mallon AM; MRC Harwell Institute, Mammalian Genetics Unit, Didcot, UK.; McKerlie C; Centre for Phenogenomics, Toronto, Ontario, Canada.; Hospital for Sick Children, Toronto, Ontario, Canada.; Meehan TF; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.; Kymab Group, Cambridge, UK.; Fuentes VM; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.; Newman S; Wellcome Sanger Institute, Hinxton, UK.; PetMedix, Cambridge, UK.; Nutter LMJ; Centre for Phenogenomics, Toronto, Ontario, Canada.; Hospital for Sick Children, Toronto, Ontario, Canada.; Oh GT; Immune and Vascular Cell Network Research Center, National Creative Initiatives and Department of Life Sciences, Ewha Womans Univesity, Seoul, Republic of Korea.; Pavlovic G; Université de Strasbourg, CNRS, INSERM, PHENOMIN-ICS, IGBMC, Illkirch, France.; Ramirez-Solis R; Wellcome Sanger Institute, Hinxton, UK.; Rosen B; Wellcome Sanger Institute, Hinxton, UK.; AstraZeneca, Discovery Sciences, Cambridge, UK.; Ryder EJ; Wellcome Sanger Institute, Hinxton, UK.; LGC, Sport and Specialised Analytical Services, Fordham, UK.; Santos LA; MRC Harwell Institute, Mammalian Genetics Unit, Didcot, UK.; Schick J; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Genetics and Cellular Engineering Group, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum Munich, Neuherberg, Germany.; Seavitt JR; Baylor College of Medicine, Houston, TX, USA.; Sedlacek R; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic.; Seisenberger C; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Seong JK; Korea Mouse Phenotyping Center (KMPC) and BK21 Program for Veterinary Science, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.; Skarnes WC; Wellcome Sanger Institute, Hinxton, UK.; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Sorg T; Université de Strasbourg, CNRS, INSERM, PHENOMIN-ICS, IGBMC, Illkirch, France.; Steel KP; Wellcome Sanger Institute, Hinxton, UK.; Wolfson Centre for Age-Related Diseases, King's College London, London, UK.; Tamura M; RIKEN BioResource Research Center, Tsukuba, Japan.; Tocchini-Valentini GP; Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo, Italy.; Wang CL; National Laboratory Animal Center, National Applied Research Laboratories (NARLabs), Taipei, Taiwan.; Wardle-Jones H; Wellcome Sanger Institute, Hinxton, UK.; Wattenhofer-Donzé M; Université de Strasbourg, CNRS, INSERM, PHENOMIN-ICS, IGBMC, Illkirch, France.; Wells S; MRC Harwell Institute, Mary Lyon Centre, Didcot, UK.; Wiles MV; The Jackson Laboratory, Bar Harbor, ME, USA.; Willis BJ; Mouse Biology Program, University of California, Davis, Davis, CA, USA.; Wood JA; Mouse Biology Program, University of California, Davis, Davis, CA, USA.; Wurst W; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Developmental Genetics, Center of Life and Food Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany.; German Center for Neurodegenerative Diseases, Munich, Germany.; Xu Y; CAM-SU Genomic Resource Center, Soochow University, Suzhou, China.; Teboul L; MRC Harwell Institute, Mary Lyon Centre, Didcot, UK. l.teboul@har.mrc.ac.uk.; Murray SA; The Jackson Laboratory, Bar Harbor, ME, USA. steve.murray@jax.org. |
| Corporate Authors: | International Mouse Phenotyping Consortium (IMPC) |
| Source: | Nature genetics [Nat Genet] 2021 Apr; Vol. 53 (4), pp. 416-419. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, NY : Nature Pub. Co., c1992- |
| MeSH Terms: | Gene Deletion* ; Genetic Association Studies* ; Genome* ; Genotype*; Mouse Embryonic Stem Cells/cytology ; Mouse Embryonic Stem Cells/metabolism ; Animals ; Information Dissemination ; International Cooperation ; Internet ; Mice ; Mice, Knockout ; Mutagenesis ; Phenotype |
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| Grant Information: | MR/V000292/1 United Kingdom MRC_ Medical Research Council; A410 United Kingdom MRC_ Medical Research Council; G0300212 United Kingdom MRC_ Medical Research Council; P30 CA034196 United States CA NCI NIH HHS; U42 OD011174 United States OD NIH HHS; MC_U142684172 United Kingdom MRC_ Medical Research Council; MC_UP_1502/3 United Kingdom MRC_ Medical Research Council; U42 OD011185 United States OD NIH HHS; MC_UP_1502/1 United Kingdom MRC_ Medical Research Council; UM1 OD023222 United States OD NIH HHS; U54 HG006370 United States HG NHGRI NIH HHS; MC_QA137918 United Kingdom MRC_ Medical Research Council; U42 OD011175 United States OD NIH HHS; United Kingdom WT_ Wellcome Trust |
| Contributed Indexing: | Investigator: JJ Gallegos; JR Green; R Bohat; K Zimmel; M Pereira; S MacMaster; S Tondat; L Wei; T Carroll; J Cabezas; Q Fan-Lan; E Jacob; A Creighton; P Castellanos-Penton; O Danisment; S Clarke; J Joeng; D Kelly; C To; R van Bruggen; V Gailus-Durner; H Fuchs; S Marschall; S Dunst; M Romberger; B Rey; S Fessele; P Gormanns; R Friedel; C Kaloff; A Hörlein; S Teichmann; A Tasdemir; H Krause; D German; A Könitzer; S Weber; J Beig; M McKay; R Bedigian; S Dion; P Kutny; J Kelmenson; E Perry; D Nguyen-Bresinsky; A Seluke; T Leach; S Perkins; A Slater; M Petit; R Urban; S Kales; M DaCosta; M McFarland; R Palazola; KA Peterson; K Svenson; RE Braun; R Taft; M Rhue; J Garay; D Clary; R Araiza; K Grimsrud; L Bower; NL Anchell; KM Jager; DL Young; PT Dao; W Gardiner; T Bell; J Kenyon; ME Stewart; D Lynch; J Loeffler; A Caulder; R Hillier; MM Quwailid; R Zaman; L Santos; Y Obata; M Iwama; H Nakata; T Hashimoto; M Kadota; H Masuya; N Tanaka; I Miura; I Yamada; T Furuse; M Selloum; S Jacquot; A Ayadi; D Ali-Hadji; P Charles; E Le Marchand; A El Amri; C Kujath; JV Fougerolle; P Mellul; S Legeay; L Vasseur; AI Moro; R Lorentz; L Schaeffer; D Dreyer; V Erbs; B Eisenmann; G Rossi; L Luppi; A Mertz; A Jeanblanc; E Grau; C Sinclair; E Brown; H Kundi; A Madich; M Woods; L Pearson; D Mayhew; N Griggs; R Houghton; J Bussell; C Ingle; S Valentini; D Gleeson; D Sethi; T Bayzetinova; J Burvill; B Habib; L Weavers; R Maswood; E Miklejewska; R Cook; R Platte; S Price; S Vyas; A Collinson; M Hardy; P Dalvi; V Iyer; T West; M Thomas; A Mujica; E Sins; D Barrett; M Dobbie; A Grobler; G Loots; R Hayeshi; LM Scholtz; C Bester; W Pheiffer; K Venter; F Bosch |
| Entry Date(s): | Date Created: 20210409 Date Completed: 20210420 Latest Revision: 20250530 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC8397259 |
| DOI: | 10.1038/s41588-021-00825-y |
| PMID: | 33833456 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't