Possible clinical implications of prostate capsule thickness and glandular epithelial cell density in benign prostate hyperplasia.
| Title: | Possible clinical implications of prostate capsule thickness and glandular epithelial cell density in benign prostate hyperplasia. |
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| Authors: | Holder KG; Department of Urology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.; Galvan B; Department of Urology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.; Knight AS; Department of Urology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.; Ha F; Department of Urology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.; Collins R; Department of Urology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.; Weaver PE; Department of Urology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.; Brandi L; Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.; de Riese WT; Department of Urology, Texas Tech University Health Sciences Center, Lubbock, TX, USA. werner.deriese@ttuhsc.edu. |
| Source: | Investigative and clinical urology [Investig Clin Urol] 2021 Jul; Vol. 62 (4), pp. 423-429. Date of Electronic Publication: 2021 May 31. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Korean Urological Association Country of Publication: Korea (South) NLM ID: 101674989 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2466-054X (Electronic) Linking ISSN: 24660493 NLM ISO Abbreviation: Investig Clin Urol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Seoul : Korean Urological Association, [2016]- |
| MeSH Terms: | Epithelial Cells/*pathology ; Prostate/*pathology ; Prostatic Hyperplasia/*pathology ; Prostatic Neoplasms/*pathology; Prostatic Hyperplasia/surgery ; Aged ; Atrophy ; Fibrosis ; Humans ; Image Processing, Computer-Assisted ; Male ; Middle Aged ; Organ Sparing Treatments ; Prostatectomy ; Retrospective Studies |
| Abstract: | Purpose: The negative correlation between BPH-size and incidence of prostate cancer (PCa) is well-documented in the literature, however the exact mechanism is not well-understood. The present study uses histo-anatomical imaging to study prostate volume in correlation to prostate capsule thickness, and glandular epithelial cell density within the peripheral zone (PZ).; Materials and Methods: Specimens were selected from radical prostatectomies ranging from 20 to 160 mL based on ease of anatomical reconstruction by the slides. A total of 60 patients were selected and underwent quantitative measurements of prostate capsule thickness and glandular epithelial density within the PZ using computer-based imaging software. Pearson's correlation and a stepwise multiple linear regression analysis was conducted to determine the relationship between these measured parameters and the clinical characteristic of these patients.; Results: Pearson's correlation analysis revealed a strongly significant, negative correlation between prostate volume and glandular epithelial cell density (r(58)=-0.554, p |
| Competing Interests: | The authors have nothing to disclose. |
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| Contributed Indexing: | Keywords: Image processing; Prostate; Prostatic hyperplasia |
| Entry Date(s): | Date Created: 20210604 Date Completed: 20220202 Latest Revision: 20240402 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC8246008 |
| DOI: | 10.4111/icu.20200605 |
| PMID: | 34085792 |
| Database: | MEDLINE |
Journal Article