Effects of chiropractic spinal manipulation on laser-evoked pain and brain activity.
| Title: | Effects of chiropractic spinal manipulation on laser-evoked pain and brain activity. |
|---|---|
| Authors: | Provencher B; Department of Anatomy, Université du Québec à Trois-Rivières, 3351 boul. des Forges, C.P. 500, Trois-Rivières, QC, G9A 5H7, Canada.; CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, G9A 5H7, Canada.; Northon S; Department of Anatomy, Université du Québec à Trois-Rivières, 3351 boul. des Forges, C.P. 500, Trois-Rivières, QC, G9A 5H7, Canada.; CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, G9A 5H7, Canada.; Gevers Montoro C; Department of Anatomy, Université du Québec à Trois-Rivières, 3351 boul. des Forges, C.P. 500, Trois-Rivières, QC, G9A 5H7, Canada.; CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, G9A 5H7, Canada.; Madrid College of Chiropractic, Madrid, Spain.; O'Shaughnessy J; Department of Chiropractic, Université du Québec à Trois-Rivières, Trois-Rivières, QC, G9A 5H7, Canada.; Piché M; Department of Anatomy, Université du Québec à Trois-Rivières, 3351 boul. des Forges, C.P. 500, Trois-Rivières, QC, G9A 5H7, Canada. mathieu.piche@uqtr.ca.; CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, G9A 5H7, Canada. mathieu.piche@uqtr.ca. |
| Source: | The journal of physiological sciences : JPS [J Physiol Sci] 2021 Jun 24; Vol. 71 (1), pp. 20. Date of Electronic Publication: 2021 Jun 24. |
| Publication Type: | Journal Article; Randomized Controlled Trial |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 101262417 Publication Model: Electronic Cited Medium: Internet ISSN: 1880-6562 (Electronic) Linking ISSN: 18806546 NLM ISO Abbreviation: J Physiol Sci Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2025- : [New York] : Elsevier; Original Publication: Tokyo, Japan : Physiological Society of Japan, c2006- |
| MeSH Terms: | Manipulation, Spinal*/methods; Brain/*physiology ; Pain/*prevention & control; Evoked Potentials/physiology ; Lasers/adverse effects ; Adult ; Electroencephalography ; Female ; Humans ; Male |
| Abstract: | The aim of this study was to examine the mechanisms underlying hypoalgesia induced by spinal manipulation (SM). Eighty-two healthy volunteers were assigned to one of the four intervention groups: no intervention, SM at T4 (homosegmental to pain), SM at T8 (heterosegmental to pain) or light mechanical stimulus at T4 (placebo). Eighty laser stimuli were applied on back skin at T4 to evoke pain and brain activity related to Aδ- and C-fibers activation. The intervention was performed after 40 stimuli. Laser pain was decreased by SM at T4 (p = 0.028) but not T8 (p = 0.13), compared with placebo. However, brain activity related to Aδ-fibers activation was not significantly modulated (all p > 0.05), while C-fiber activity could not be measured reliably. This indicates that SM produces segmental hypoalgesia through inhibition of nociceptive processes that are independent of Aδ fibers. It remains to be clarified whether the effect is mediated by the inhibition of C-fiber activity. |
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| Grant Information: | 06659 Natural Science and Engineering Research Council of Canada |
| Contributed Indexing: | Keywords: Electroencephalography; Hypoalgesia; Nociceptive fibers; Spinal manipulation |
| Entry Date(s): | Date Created: 20210625 Date Completed: 20211224 Latest Revision: 20250227 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10717656 |
| DOI: | 10.1186/s12576-021-00804-2 |
| PMID: | 34167458 |
| Database: | MEDLINE |
Journal Article; Randomized Controlled Trial