Covid-19 and Growth Hormone/Insulin-Like Growth Factor 1: Study in Critically and Non-Critically Ill Patients.
| Title: | Covid-19 and Growth Hormone/Insulin-Like Growth Factor 1: Study in Critically and Non-Critically Ill Patients. |
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| Authors: | Ilias I; Department of Endocrinology, Diabetes and Metabolism, Elena Venizelou Hospital, Athens, Greece.; Diamantopoulos A; Department of Endocrinology, Diabetes and Metabolism, Evagelismos Hospital, Athens, Greece.; Botoula E; Department of Endocrinology, Diabetes and Metabolism, Evagelismos Hospital, Athens, Greece.; Athanasiou N; First Department of Critical Care Medicine & Pulmonary Services, Medical School of National & Kapodistrian University of Athens, Evagelismos Hospital, Athens, Greece.; Zacharis A; First Department of Critical Care Medicine & Pulmonary Services, Medical School of National & Kapodistrian University of Athens, Evagelismos Hospital, Athens, Greece.; Tsipilis S; Department of Pulmonary Medicine, Evagelismos Hospital, Athens, Greece.; Jahaj E; First Department of Critical Care Medicine & Pulmonary Services, Medical School of National & Kapodistrian University of Athens, Evagelismos Hospital, Athens, Greece.; Vassiliou AG; First Department of Critical Care Medicine & Pulmonary Services, Medical School of National & Kapodistrian University of Athens, Evagelismos Hospital, Athens, Greece.; Vassiliadi DA; Department of Endocrinology, Diabetes and Metabolism, Evagelismos Hospital, Athens, Greece.; Kotanidou A; First Department of Critical Care Medicine & Pulmonary Services, Medical School of National & Kapodistrian University of Athens, Evagelismos Hospital, Athens, Greece.; Tsagarakis S; Department of Endocrinology, Diabetes and Metabolism, Evagelismos Hospital, Athens, Greece.; Dimopoulou I; First Department of Critical Care Medicine & Pulmonary Services, Medical School of National & Kapodistrian University of Athens, Evagelismos Hospital, Athens, Greece. |
| Source: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2021 Jun 16; Vol. 12, pp. 644055. Date of Electronic Publication: 2021 Jun 16 (Print Publication: 2021). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Lausanne : Frontiers Research Foundation] |
| MeSH Terms: | Critical Illness*/mortality; COVID-19/*metabolism ; COVID-19/*pathology ; Human Growth Hormone/*metabolism ; Insulin-Like Growth Factor I/*metabolism; COVID-19/diagnosis ; COVID-19/mortality ; Greece/epidemiology ; Hospitalization/statistics & numerical data ; Intensive Care Units/statistics & numerical data ; SARS-CoV-2/physiology ; Survivors/statistics & numerical data ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Severity of Illness Index |
| Abstract: | Objective: We aimed to measure insulin-like growth factor 1 (IGF1) and growth hormone (GH) in critically and non-critically ill patients with Covid-19 and assess them vis-a-vis clinical and laboratory parameters and prognostic tools.; Subjects and Methods: We included patients who were admitted to the wards or the ICU of the largest Covid-19 referral hospital in Greece; patients with non-Covid-19 pneumonia served as controls. Apart from the routine laboratory work-up for Covid-19 we measured GH and IGF1 (and calculated normalized IGF-1 values as standard deviation scores; SDS), after blood sampling upon admission to the wards or the ICU.; Results: We studied 209 critically and non-critically ill patients with Covid-19 and 39 control patients. Patients with Covid-19 who were ICU non-survivors were older and presented with a worse hematological/biochemical profile (including white blood cell count, troponin, glucose, aminotransferases and lactate dehydrogenase) compared to ICU survivors or Covid-19 survivors in the wards. Overall, IGF-1 SDS was higher in Covid-19 survivors compared to non-survivors (-0.96 ± 1.89 vs -2.05 ± 2.48, respectively, p=0.030). No significant differences were noted in GH between the groups. Nevertheless, in critically ill patients with Covid-19, the prognostic value of IGF-1 (raw data), IGF-1 (SDS) and GH for survival/non-survival was on a par with that of APACHE II and SOFA (with a marginal difference between GH and SOFA).; Conclusion: In conclusion, our findings suggest that there might be an association between low IGF1 (and possibly GH) and poor outcome in patients with Covid-19.; (Copyright © 2021 Ilias, Diamantopoulos, Botoula, Athanasiou, Zacharis, Tsipilis, Jahaj, Vassiliou, Vassiliadi, Kotanidou, Tsagarakis and Dimopoulou.) |
| Competing Interests: | The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
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| Contributed Indexing: | Keywords: growth hormone; hospitalization; humans; insulin-like growth factor 1; pandemics; severe acute respiratory syndrome coronavirus 2 |
| Substance Nomenclature: | 0 (IGF1 protein, human); 12629-01-5 (Human Growth Hormone); 67763-96-6 (Insulin-Like Growth Factor I) |
| Entry Date(s): | Date Created: 20210705 Date Completed: 20210707 Latest Revision: 20210707 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC8242942 |
| DOI: | 10.3389/fendo.2021.644055 |
| PMID: | 34220703 |
| Database: | MEDLINE |
Journal Article