Genetic Liability to Cannabis Use Disorder and COVID-19 Hospitalization.
| Title: | Genetic Liability to Cannabis Use Disorder and COVID-19 Hospitalization. |
|---|---|
| Authors: | Hatoum AS; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.; Morrison CL; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado.; Colbert SMC; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.; Winiger EA; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado.; Johnson EC; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.; Agrawal A; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.; Bogdan R; Department of Psychological and Brain Sciences, Washington University in St Louis, St. Louis, Missouri. |
| Source: | Biological psychiatry global open science [Biol Psychiatry Glob Open Sci] 2021 Dec; Vol. 1 (4), pp. 317-323. Date of Electronic Publication: 2021 Jun 19. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Inc. on behalf of Society of Biological Psychiatry Country of Publication: United States NLM ID: 9918227369306676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2667-1743 (Electronic) Linking ISSN: 26671743 NLM ISO Abbreviation: Biol Psychiatry Glob Open Sci Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [New York] : Elsevier Inc. on behalf of Society of Biological Psychiatry, [2021]- |
| Abstract: | Background: Vulnerability to COVID-19 hospitalization has been linked to behavioral risk factors, including combustible psychoactive substance use (e.g., tobacco smoking). Paralleling the COVID-19 pandemic crisis have been increasingly permissive laws for recreational cannabis use. Cannabis use disorder (CUD) is a psychiatric disorder that is heritable and genetically correlated with respiratory disease, independent of tobacco smoking. We examined the genetic relationship between CUD and COVID-19 hospitalization.; Methods: We estimated the genetic correlation between CUD (case: n = 14,080; control: n = 343,726) and COVID-19 hospitalization (case: n = 9373; control: n = 1,197,256) using summary statistics from genome-wide association studies. Using independent genome-wide association studies conducted before the pandemic, we controlled for several covariates (i.e., tobacco use phenotypes, problematic alcohol use, body mass index, fasting glucose, forced expiratory volume, education attainment, risk taking, attention-deficit/hyperactivity disorder, Townsend deprivation index, chronic obstructive pulmonary disease, hypertension, and type 2 diabetes) using genomic structural equation modeling. Genetic causality between CUD and COVID-19 hospitalization was estimated using latent causal variable models.; Results: Genetic vulnerability to COVID-19 was correlated with genetic liability to CUD (r G = 0.423 [SE = 0.0965], p = 1.33 × 10-6); this association remained when accounting for genetic liability to related risk factors and covariates (b = 0.381-0.539, p = .012-.049). Latent causal variable analysis revealed causal effect estimates that were not statistically significant.; Conclusions: Problematic cannabis use and vulnerability to serious COVID-19 complications share genetic underpinnings that are unique from common correlates. While CUD may plausibly contribute to severe COVID-19 presentations, causal inference models yielded no evidence of putative causation. Curbing excessive cannabis use may mitigate the impact of COVID-19.; (© 2021 Published by Elsevier Inc on behalf of Society of Biological Psychiatry.) |
| Comments: | Update of: medRxiv. 2020 Nov 18:2020.11.15.20229971. doi: 10.1101/2020.11.15.20229971.. (PMID: 33236033) |
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| Grant Information: | K02 DA032573 United States DA NIDA NIH HHS; R21 AA027827 United States AA NIAAA NIH HHS; T32 HD007289 United States HD NICHD NIH HHS; U01 AG052564 United States AG NIA NIH HHS; U01 MH109532 United States MH NIMH NIH HHS; F32 AA027435 United States AA NIAAA NIH HHS; R01 DA046224 United States DA NIDA NIH HHS; T32 DA007261 United States DA NIDA NIH HHS; T32 MH016880 United States MH NIMH NIH HHS |
| Contributed Indexing: | Keywords: COVID-19; Cannabis use disorder; Genetic correlations; Genome-wide association statistics; Tobacco use |
| Entry Date(s): | Date Created: 20210708 Latest Revision: 20240211 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC8214324 |
| DOI: | 10.1016/j.bpsgos.2021.06.005 |
| PMID: | 34235496 |
| Database: | MEDLINE |
Journal Article