Association Between Amygdala Volume and Trajectories of Neuropsychiatric Symptoms in Alzheimer's Disease and Dementia With Lewy Bodies.
| Title: | Association Between Amygdala Volume and Trajectories of Neuropsychiatric Symptoms in Alzheimer's Disease and Dementia With Lewy Bodies. |
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| Authors: | Jaramillo-Jimenez A; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway.; Faculty of Health Sciences, University of Stavanger, Stavanger, Norway.; Grupo de Neurociencias de Antioquia, School of Medicine, Universidad de Antioquia, Medellín, Colombia.; Grupo Neuropsicología y Conducta, School of Medicine, Universidad de Antioquia, Medellín, Colombia.; Semillero de Investigación SINAPSIS, School of Medicine, Universidad de Antioquia, Medellín, Colombia.; Semillero de Investigación NeuroCo, School of Medicine and Engenieering, Universidad de Antioquia, Medellín, Colombia.; Giil LM; Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Internal Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway.; Tovar-Rios DA; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway.; Universidad Del Valle, Grupo de Investigación en Estadística Aplicada - INFERIR, Faculty of Engineering, Santiago De Cali, Valle Del Cauca, Colombia.; Universidad Del Valle, Prevención y Control de la Enfermedad Crónica - PRECEC, Faculty of Health, Santiago De Cali, Valle Del Cauca, Colombia.; Borda MG; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway.; Faculty of Health Sciences, University of Stavanger, Stavanger, Norway.; Semillero de Neurociencias y Envejecimiento, Medical School, Ageing Institute, Pontificia Universidad Javeriana, Bogota, Colombia.; Ferreira D; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Department of Radiology, Mayo Clinic, Rochester, MN, United States.; Brønnick K; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway.; Faculty of Health Sciences, University of Stavanger, Stavanger, Norway.; Oppedal K; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway.; Stavanger Medical Imaging Laboratory, Department of Radiology, Stavanger University Hospital, Stavanger, Norway.; Department of Electrical Engineering and Computer Science, University of Stavanger, Stavanger, Norway.; Aarsland D; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway.; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom. |
| Source: | Frontiers in neurology [Front Neurol] 2021 Jul 07; Vol. 12, pp. 679984. Date of Electronic Publication: 2021 Jul 07 (Print Publication: 2021). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101546899 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2295 (Print) Linking ISSN: 16642295 NLM ISO Abbreviation: Front Neurol Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [Lausanne : Frontiers Research Foundation, 2010]- |
| Abstract: | Introduction: The amygdala is implicated in psychiatric illness. Even as the amygdala undergoes significant atrophy in mild dementia, amygdala volume is underexplored as a risk factor for neuropsychiatric symptoms (NPS). Objective: To analyze the association between baseline amygdala volume and the longitudinal trajectories of NPS and cognitive decline in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) over 5 years. Methods: Eighty-nine patients with mild dementia were included (AD = 55; DLB = 34). Amygdala volume was segmented from structural magnetic resonance images (sMRI) using a semi-automatic method (Freesurfer 6.0) and normalized by intracranial volumes. The intracranial volume-normalized amygdala was used as a predictor of the Neuropsychiatric Inventory (NPI) total score, ordinal NPI item scores (0 = absence of symptoms, 1-3 = mild symptoms, ≥4 = clinically relevant symptoms), and Mini-Mental State Examination (MMSE) as measured annually over 5 years using gamma, ordinal, and linear mixed-effects models, respectively. The models were adjusted for demographic variables, diagnosis, center of sMRI acquisition, and cognitive performance. Multiple testing-corrected p-values (q-values) are reported. Results: Larger intracranial volume-normalized amygdala was associated with less agitation/aggression (odds ratio (OR) = 0.62 [0.43, 0.90], p = 0.011, q = 0.038) and less MMSE decline per year (fixed effect = 0.70, [0.29, 1.03], p = 0.001, q = 0.010) but more depression (OR = 1.49 [1.09, 2.04], p = 0.013, q = 0.040). Conclusions: Greater amygdala volume in mild dementia is associated with lower odds of developing agitation/aggression, but higher odds of developing depression symptoms during the 5-year study period.; (Copyright © 2021 Jaramillo-Jimenez, Giil, Tovar-Rios, Borda, Ferreira, Brønnick, Oppedal and Aarsland.) |
| Competing Interests: | The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
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| Contributed Indexing: | Keywords: Alzheimer's disease; amygdala; dementia with lewy bodies; magnetic resonance imaging; neuropsychiatric symptoms |
| Entry Date(s): | Date Created: 20210726 Latest Revision: 20210727 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC8292611 |
| DOI: | 10.3389/fneur.2021.679984 |
| PMID: | 34305791 |
| Database: | MEDLINE |
Journal Article