High optical-throughput spectroscopic singlet oxygen and photosensitizer luminescence dosimeter for monitoring of photodynamic therapy.
| Title: | High optical-throughput spectroscopic singlet oxygen and photosensitizer luminescence dosimeter for monitoring of photodynamic therapy. |
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| Authors: | Zhao Y; Physical Sciences Inc, 20 New England Business Center Dr., Andover, MA, 01810, USA.; Moritz T; Physical Sciences Inc, 20 New England Business Center Dr., Andover, MA, 01810, USA.; Hinds MF; Physical Sciences Inc, 20 New England Business Center Dr., Andover, MA, 01810, USA.; Gunn JR; Thayer School of Engineering, Dartmouth College, 14 Engineering Dr., Hanover, NH, 03755, USA.; Shell JR; Thayer School of Engineering, Dartmouth College, 14 Engineering Dr., Hanover, NH, 03755, USA.; Pogue BW; Thayer School of Engineering, Dartmouth College, 14 Engineering Dr., Hanover, NH, 03755, USA.; Davis SJ; Physical Sciences Inc, 20 New England Business Center Dr., Andover, MA, 01810, USA. |
| Source: | Journal of biophotonics [J Biophotonics] 2021 Nov; Vol. 14 (11), pp. e202100088. Date of Electronic Publication: 2021 Aug 06. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Language: | English |
| Journal Info: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101318567 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1864-0648 (Electronic) Linking ISSN: 1864063X NLM ISO Abbreviation: J Biophotonics Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Weinheim : Wiley-VCH |
| MeSH Terms: | Photochemotherapy* ; Singlet Oxygen*; Luminescence ; Photosensitizing Agents ; Radiation Dosimeters |
| Abstract: | We report a high light-throughput spectroscopic dosimeter system that is able to noninvasively measure luminescence signals of singlet oxygen (1 O2 ) produced during photodynamic therapy (PDT) using a CW (continuous wave) light source. The system is based on a compact, fiber-coupled, high collection efficiency spectrometer (>50% transmittance) designed to maximize optical throughput but with sufficient spectral resolution (~7 nm). This is adequate to detect 1 O2 phosphorescence in the presence of strong luminescence background in vivo. This system provides simultaneous acquisition of multiple spectral data points, allowing for more accurate determination of luminescence baseline via spectral fitting and thus the extraction of 1 O2 phosphorescence signal based solely on spectroscopic decomposition, without the need for time-gating. Simultaneous collection of photons at different wavelengths improves the quantum efficiency of the system when compared to sequential spectral measurements such as filter-wheel or tunable-filter based systems. A prototype system was tested during in vivo PDT tumor regression experiments using benzoporphyrin derivative (BPD) photosensitizer. It was found that the treatment efficacy (tumor growth inhibition rate) correlated more strongly with 1 O2 phosphorescence than with PS fluorescence. These results indicate that this high photon-collection efficiency spectrometer instrument may offer a viable option for real-time 1 O2 dosimetry during PDT treatment using CW light.; (© 2021 Wiley-VCH GmbH.) |
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| Grant Information: | P01CA084203 United States NH NIH HHS; 2R44CA213607-02 United States NH NIH HHS |
| Contributed Indexing: | Keywords: near-infrared spectroscopy; photodynamic therapy; photosensitizer luminescence; singlet oxygen dosimeter |
| Substance Nomenclature: | 0 (Photosensitizing Agents); 17778-80-2 (Singlet Oxygen) |
| Entry Date(s): | Date Created: 20210729 Date Completed: 20211209 Latest Revision: 20211214 |
| Update Code: | 20260130 |
| DOI: | 10.1002/jbio.202100088 |
| PMID: | 34323374 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural