Muscle Volume and Intramuscular Fat of the Tongue Evaluated With MRI Predict Malnutrition in People Living With Dementia: A 5-Year Follow-up Study.
| Title: | Muscle Volume and Intramuscular Fat of the Tongue Evaluated With MRI Predict Malnutrition in People Living With Dementia: A 5-Year Follow-up Study. |
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| Authors: | Borda MG; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Norway.; Faculty of Health Sciences, University of Stavanger, Norway.; Bani Hassan E; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, Victoria, Australia.; Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, Victoria, Australia.; Weon JH; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, Victoria, Australia.; Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, Victoria, Australia.; Wakabayashi H; Department of Rehabilitation Medicine, Tokyo Women's Medical University Hospital, Japan.; Tovar-Rios DA; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Norway.; Universidad del Valle, School of Statistics, Santiago de Cali, Colombia.; Oppedal K; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Norway.; Department of Electrical Engineering & Computer Science, University of Stavanger, Norway.; Aarsland D; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Norway.; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK.; Duque G; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, Victoria, Australia.; Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, Victoria, Australia. |
| Source: | The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2022 Feb 03; Vol. 77 (2), pp. 228-234. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: published on behalf of the Gerontological Society of America by Oxford University Press Country of Publication: United States NLM ID: 9502837 Publication Model: Print Cited Medium: Internet ISSN: 1758-535X (Electronic) Linking ISSN: 10795006 NLM ISO Abbreviation: J Gerontol A Biol Sci Med Sci Subsets: MEDLINE |
| Imprint Name(s): | Publication: Washington, DC : published on behalf of the Gerontological Society of America by Oxford University Press; Original Publication: Washington, DC : Gerontological Society of America, c1995- |
| MeSH Terms: | Dementia*/epidemiology ; Malnutrition*/diagnosis ; Malnutrition*/epidemiology; Tongue/diagnostic imaging ; Aged ; Aged, 80 and over ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging ; Muscles |
| Abstract: | Malnutrition is highly prevalent in older persons with dementia. Therefore, strong predictors of malnutrition in this population are crucial to initiating early interventions. This study evaluates the association between the probability of having malnutrition with the muscle volume and intramuscular fat (iMAT) of the masseter and the tongue in magnetic resonance imaging (MRI) of community-dwelling older persons diagnosed with mild dementia followed up for 5 years. This is a longitudinal study conducted in the western part of Norway. Muscle volume and iMAT of the tongue and masseter were computed from structural head MRI obtained from 65 participants of the Dementia Study of Western Norway using Slice-O-Matic software for segmentation. Malnutrition was assessed using the Global Leadership Initiative on Malnutrition Index. Linear mixed models were conducted. Having malnutrition at baseline was associated with lower muscle volume (odds ratio [OR] 0.60, standard error [SE] 0.20; p = .010) and higher iMAT (OR 3.31, SE 0.46; p = .010) in the tongue. At 5 years follow-up, those with lower muscle volume (OR 0.55, SE 0.20; p = .002) and higher iMAT (OR 2.52, SE 0.40; p = .022) in the tongue had a higher probability of presenting malnutrition. The masseter iMAT and volume were not associated with malnutrition in any of the adjusted models. In people diagnosed with mild dementia, tongue muscle volume and iMAT were associated with baseline malnutrition and the probability of developing malnutrition in a 5-year trajectory. In the masseter, there were no significant associations after adjustments.; (© The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| Grant Information: | United Kingdom DH_ Department of Health |
| Contributed Indexing: | Keywords: Dementia; Intramuscular fat; Lewy body dementia; Malnutrition; Sarcopenia |
| Entry Date(s): | Date Created: 20210802 Date Completed: 20220418 Latest Revision: 20220418 |
| Update Code: | 20260130 |
| DOI: | 10.1093/gerona/glab224 |
| PMID: | 34338751 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't