A multi-center retrospective cohort study defines the spectrum of kidney pathology in Coronavirus 2019 Disease (COVID-19).
| Title: | A multi-center retrospective cohort study defines the spectrum of kidney pathology in Coronavirus 2019 Disease (COVID-19). |
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| Authors: | May RM; Arkana Laboratories, Little Rock, Arkansas, USA.; Cassol C; Arkana Laboratories, Little Rock, Arkansas, USA.; Hannoudi A; University of Michigan, Ann Arbor, Michigan, USA.; Larsen CP; Arkana Laboratories, Little Rock, Arkansas, USA.; Lerma EV; Department of Internal Medicine, University of Illinois at Chicago College of Medicine/Advocate Christ Medical Center, Oak Lawn, Illinois, USA.; Haun RS; Arkana Laboratories, Little Rock, Arkansas, USA.; Braga JR; Nephrology Division, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Hassen SI; Arkana Laboratories, Little Rock, Arkansas, USA.; Wilson J; Arkana Laboratories, Little Rock, Arkansas, USA.; VanBeek C; AmeriPath Laboratories, Oklahoma City, Oklahoma, USA.; Vankalakunti M; Department of Pathology, Manipal Hospital-Bangalore, Bangalore, Karnataka, India.; Barnum L; Arkana Laboratories, Little Rock, Arkansas, USA.; Walker PD; Arkana Laboratories, Little Rock, Arkansas, USA.; Bourne TD; Arkana Laboratories, Little Rock, Arkansas, USA.; Messias NC; Arkana Laboratories, Little Rock, Arkansas, USA.; Ambruzs JM; Arkana Laboratories, Little Rock, Arkansas, USA.; Boils CL; Arkana Laboratories, Little Rock, Arkansas, USA.; Sharma SS; Arkana Laboratories, Little Rock, Arkansas, USA.; Cossey LN; Arkana Laboratories, Little Rock, Arkansas, USA.; Baxi PV; Nephrology Division, Rush University Medical Center, Chicago, Illinois, USA.; Palmer M; Department of Pathology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Zuckerman JE; Department of Pathology and Laboratory Medicine, University of California, Los Angeles Health System, Los Angeles, California, USA.; Walavalkar V; Department of Pathology, University of California, San Francisco Medical Center, San Francisco, California, USA.; Urisman A; Department of Pathology, University of California, San Francisco Medical Center, San Francisco, California, USA.; Gallan AJ; Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.; Al-Rabadi LF; Division of Nephrology, University of Utah School of Medicine, Salt Lake City, Utah, USA.; Rodby R; Nephrology Division, Rush University Medical Center, Chicago, Illinois, USA.; Luyckx V; Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, USA; Division of Nephrology, Kantonal Hospital of Graubunden, Chur, Switzerland.; Espino G; Albuquerque Nephrology Associates, Albuquerque, New Mexico, USA.; Santhana-Krishnan S; Renal Associates of West Michigan, Grand Rapids, Michigan, USA.; Alper B; Division of Nephrology, Tulane School of Medicine, New Orleans, Louisiana, USA.; Lam SG; Nephrology and Hypertension Associated Ltd., Oxford, Mississippi, USA.; Hannoudi GN; Michigan Kidney Consultants, Pontiac, Michigan, USA.; Matthew D; Shoals Kidney & Hypertension Center, Florence, Alabama, USA.; Belz M; Iowa Kidney Physicians PC, Des Moines, Iowa, USA.; Singer G; Midwest Nephrology Associates, St. Peters, Missouri, USA.; Kunaparaju S; Richmond Nephrology Associates, Richmond, Virginia, USA.; Price D; Nephrology Associates of NE Florida, Jacksonville, Florida, USA.; Chawla S; Nephrology Associates of Northern Illinois and Indiana, Merrillville, Indiana, USA.; Rondla C; Georgia Nephrology, Lawrenceville, Georgia, USA.; Abdalla MA; The Kidney Clinic, Snellville, Georgia, USA.; Britton ML; Nephrology & Hypertension Associates Ltd., Tupelo, Mississippi, USA.; Paul S; Shoals Kidney & Hypertension Center, Florence, Alabama, USA.; Ranjit U; Nephrology Associates of Central Florida, Orlando, Florida, USA.; Bichu P; Nephrology Associates of Tidewater Ltd., Norfolk, Virginia, USA.; Williamson SR; Division of Nephrology, Cleveland Clinic, Cleveland, Ohio, USA.; Sharma Y; Division of Nephrology, Henry Ford Hospital, Detroit, Michigan, USA.; Gaspert A; Division of Nephrology, Kantonal Hospital of Graubunden, Chur, Switzerland.; Grosse P; Division of Nephrology, Kantonal Hospital of Graubunden, Chur, Switzerland.; Meyer I; Mt Auburn Nephrology, Cincinnati, Ohio, USA.; Vasudev B; Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.; El Kassem M; Mohamad El Kassem, MD (private practice), Nephrology, Coral Springs, Florida, USA.; Velez JCQ; Department of Nephrology, Ochsner Health System, New Orleans, Louisiana, USA; Ochsner Clinical School, The University of Queensland (Australia), St. Lucia, Queensland, Australia.; Caza TN; Arkana Laboratories, Little Rock, Arkansas, USA. Electronic address: tiffany.caza@arkanalabs.com. |
| Source: | Kidney international [Kidney Int] 2021 Dec; Vol. 100 (6), pp. 1303-1315. Date of Electronic Publication: 2021 Aug 03. |
| Publication Type: | Journal Article; Multicenter Study |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 0323470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1755 (Electronic) Linking ISSN: 00852538 NLM ISO Abbreviation: Kidney Int Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2016- : New York : Elsevier; Original Publication: New York, Springer-Verlag. |
| MeSH Terms: | Acute Kidney Injury* ; COVID-19*; Apolipoprotein L1/genetics ; Humans ; Kidney ; Retrospective Studies ; SARS-CoV-2 |
| Abstract: | Kidney failure is common in patients with Coronavirus Disease-19 (COVID-19), resulting in increased morbidity and mortality. In an international collaboration, 284 kidney biopsies were evaluated to improve understanding of kidney disease in COVID-19. Diagnoses were compared to five years of 63,575 native biopsies prior to the pandemic and 13,955 allograft biopsies to identify diseases that have increased in patients with COVID-19. Genotyping for APOL1 G1 and G2 alleles was performed in 107 African American and Hispanic patients. Immunohistochemistry for SARS-CoV-2 was utilized to assess direct viral infection in 273 cases along with clinical information at the time of biopsy. The leading indication for native biopsy was acute kidney injury (45.4%), followed by proteinuria with or without concurrent acute kidney injury (42.6%). There were more African American patients (44.6%) than patients of other ethnicities. The most common diagnosis in native biopsies was collapsing glomerulopathy (25.8%), which was associated with high-risk APOL1 genotypes in 91.7% of cases. Compared to the five-year biopsy database, the frequency of myoglobin cast nephropathy and proliferative glomerulonephritis with monoclonal IgG deposits was also increased in patients with COVID-19 (3.3% and 1.7%, respectively), while there was a reduced frequency of chronic conditions (including diabetes mellitus, IgA nephropathy, and arterionephrosclerosis) as the primary diagnosis. In transplants, the leading indication was acute kidney injury (86.4%), for which rejection was the predominant diagnosis (61.4%). Direct SARS-CoV-2 viral infection was not identified. Thus, our multi-center large case series identified kidney diseases that disproportionately affect patients with COVID-19 and demonstrated a high frequency of APOL1 high-risk genotypes within this group, with no evidence of direct viral infection within the kidney.; (Copyright © 2021 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.) |
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| Contributed Indexing: | Keywords: COVID-19; SARS-CoV-2; acute kidney injury; coronavirus; kidney biopsy; renal pathology |
| Substance Nomenclature: | 0 (APOL1 protein, human); 0 (Apolipoprotein L1) |
| Entry Date(s): | Date Created: 20210805 Date Completed: 20211124 Latest Revision: 20230413 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC8328528 |
| DOI: | 10.1016/j.kint.2021.07.015 |
| PMID: | 34352311 |
| Database: | MEDLINE |
Journal Article; Multicenter Study