Targeting joint inflammation for osteoarthritis management through stimulus-sensitive hyaluronic acid based intra-articular hydrogels.
| Title: | Targeting joint inflammation for osteoarthritis management through stimulus-sensitive hyaluronic acid based intra-articular hydrogels. |
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| Authors: | Diaz-Rodriguez P; R+D Pharma Group (GI-1645) Department of Pharmacology, Pharmacy and Pharmaceutical Technology, School of Pharmacy, Universidade de Santiago de Compostela, Santiago de Compostela, Spain; Drug Delivery Systems Group, Department of Chemical Engineering and Pharmaceutical Technology, School of Pharmacy, Universidad de La Laguna, La Laguna, Spain. Electronic address: patricia.diaz.rodriguez@usc.es.; Mariño C; R+D Pharma Group (GI-1645) Department of Pharmacology, Pharmacy and Pharmaceutical Technology, School of Pharmacy, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Vázquez JA; Group of Recycling and Valorisation of Waste Materials (REVAL), Marine Research Institute (IIM-CSIC), Vigo, Spain.; Caeiro-Rey JR; Department of Orthopaedic Surgery and Traumatology, Complexo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.; Landin M; R+D Pharma Group (GI-1645) Department of Pharmacology, Pharmacy and Pharmaceutical Technology, School of Pharmacy, Universidade de Santiago de Compostela, Santiago de Compostela, Spain. |
| Source: | Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2021 Sep; Vol. 128, pp. 112254. Date of Electronic Publication: 2021 Jun 16. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101484109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0191 (Electronic) Linking ISSN: 09284931 NLM ISO Abbreviation: Mater Sci Eng C Mater Biol Appl Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier |
| MeSH Terms: | Osteoarthritis*/drug therapy ; Hyaluronic Acid*; Inflammation/drug therapy ; Artificial Intelligence ; Humans ; Hydrogels |
| Abstract: | Numerous therapeutic strategies have been developed for osteoarthritis (OA) management, including intra-articular (IA) injections. The ideal IA formulation should control cartilage degradation and restore synovial fluid viscosity. To this end, we propose to combine thermo-sensitive polymers (poloxamers) with hyaluronic acid (HA) to develop suitable beta-lapachone (βLap) loaded IA formulations. The development of IA formulations with these components entails several difficulties: low βLap solubility, unknown βLap therapeutic dose and the bonded commitment of easy administration and viscosupplementation. An optimized formulation was designed using artificial intelligence tools based on the experimental results of a wide variety of hydrogels and its therapeutic capacity was evaluated on an ex vivo OA model. The formulation presented excellent rheological properties and significantly decreased the secretion of degradative (MMP13) and pro-inflammatory (CXCL8) molecules. Therefore, the developed formulation is a promising candidate for OA treatment restoring the synovial fluid rheological properties while decreasing inflammation and cartilage degradation.; (Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| Contributed Indexing: | Keywords: Anti-inflammatory activity; Hyaluronic acid; Intra-articular hydrogels; Osteoarthritis; Thermo-sensitive systems |
| Substance Nomenclature: | 0 (Hydrogels); 9004-61-9 (Hyaluronic Acid) |
| Entry Date(s): | Date Created: 20210903 Date Completed: 20210906 Latest Revision: 20210906 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.msec.2021.112254 |
| PMID: | 34474816 |
| Database: | MEDLINE |
Journal Article