Knowledge, attitude, and practice of clinicians about antimicrobial stewardship and resistance among hospitals of Pakistan: a multicenter cross-sectional study.
| Title: | Knowledge, attitude, and practice of clinicians about antimicrobial stewardship and resistance among hospitals of Pakistan: a multicenter cross-sectional study. |
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| Authors: | Ashraf S; Department of Cardiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. sohaib-ashraf@outlook.com.; Ashraf S; Department of Pathobiology, Riphah International University, Lahore, Pakistan. shoaib.ashraf@mail.mcgill.ca.; Ashraf M; Department of Pharmacology, King Edward Medical University, Mayo Hospital, Lahore, Pakistan. moneeb.ashraf@hotmail.com.; Imran MA; Department of Microbiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. ahmad.imran@skzmdc.edu.pk.; Choudhary ZA; Department of Internal Medicine, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan.; Hafsa HT; Department of Microbiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan.; Awais AB; Department of Internal Medicine, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan.; Kalsoom L; Department of Internal Medicine, Services Institute of Medical Sciences, Lahore, Pakistan.; Farooq I; Department of Pediatrics Surgery, Children Hospital and Institute of Child Health, Lahore, Pakistan.; Habib Z; Department of Orthopedics, Tehsil Head Quarter, Ferozwala, Shaikhupura, Pakistan.; Ashraf S; Department of Biochemistry, University of Veterinary and Animal Sciences, Lahore, Pakistan.; Iqbal QUA; Department of Internal Medicine, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan.; Ghufran M; Medico Cirujano, ESACHS (Empresa de Servico Externo de la Asociacion Chilena de Seguridad), Punta Arenas, Chile.; Sherazi SSH; Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.; Akram MK; Department of Nutrition, University of Veterinary and Animal Sciences, Lahore, Pakistan.; Akmal R; Department of Community Medicine, Sahara Medical College, Narowal, Pakistan.; Rafique S; Department of Internal Medicine, Mayo Hospital, Lahore, Pakistan.; Nawaz K; Department of Pediatrics, Sunny Downstate/Kings Country Medical Center, New York, NY, USA.; Safdar Z; Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.; Siddique UN; Department of Internal Medicine, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan.; Hassan M; Department of Internal Medicine, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan.; Arshad S; Department of Internal Medicine, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan.; Virk AR; Department of Internal Medicine, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan.; Ashraf M; Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.; Saboor QA; Department of Cardiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan.; Humayun A; Department of Community Medicine, Shaikh Khalifa Bin Zayed Al-Nahyan Medical and Dental College, Lahore, Pakistan.; Izhar M; Department of Microbiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. |
| Source: | Environmental science and pollution research international [Environ Sci Pollut Res Int] 2022 Feb; Vol. 29 (6), pp. 8382-8392. Date of Electronic Publication: 2021 Sep 06. |
| Publication Type: | Journal Article; Multicenter Study |
| Language: | English |
| Journal Info: | Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE |
| Imprint Name(s): | Publication: : Berlin : Springer; Original Publication: Landsberg, Germany : Ecomed |
| MeSH Terms: | Antimicrobial Stewardship*; Cross-Sectional Studies ; Health Knowledge, Attitudes, Practice ; Hospitals ; Humans ; Pakistan |
| Abstract: | Considering that antimicrobial resistance (AMR) is a global challenge, there is a dire need to assess the knowledge, attitude, and practice (KAP) of clinicians in AMR endemic countries. The current multicenter, cross-sectional study aimed at highlighting gaps in antimicrobial (AM) stewardship and AMR among practicing doctors working in public tertiary care teaching hospitals of Lahore, Pakistan. A KAP survey, based on a self-administered questionnaire containing 45 questions, was distributed among 336 clinicians in 6 randomly selected hospitals. Overall, 92% of the clinicians considered AMR as a worldwide problem but only 66% disagreed that cold and flu symptoms require antibiotics. Moreover, around 68% of the doctors felt confident about their practice in AM but still, 96% felt the need to get more knowledge about AM drugs. The need for refresher courses on rational antibiotic use was expressed by 84% of the participants. The main contributing factors considered for AMR by the doctors included excessive AM usage in the medical profession (87.1%) and multiple antibiotics per prescription (76.4%). Pharmacologically, AM spectrum was accurately chosen by 1.4% for Ampicillin, 0.003% for Erythromycin and 0% for Levofloxacin. Clinically, more than 50% of the clinicians used miscellaneous AM for empirical therapy of respiratory tract infection and cholecystitis. The data was analyzed using Statistical Package for Social Sciences (SPSS) version 25. It is concluded that the knowledge of clinicians is relatively poor for AM spectrum and drugs of choice for certain infections. However, the clinicians are aware of their shortcomings and desire for improvement.; (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| Contributed Indexing: | Keywords: Antibiotic misuse; Antibiotic resistance; Antimicrobial use; Antimicrobials; Resistance |
| Entry Date(s): | Date Created: 20210907 Date Completed: 20220124 Latest Revision: 20220124 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC8421064 |
| DOI: | 10.1007/s11356-021-16178-2 |
| PMID: | 34490566 |
| Database: | MEDLINE |
Journal Article; Multicenter Study