Potentiation of microglial endocannabinoid signaling alleviates neuroinflammation in Alzheimer's disease.
| Title: | Potentiation of microglial endocannabinoid signaling alleviates neuroinflammation in Alzheimer's disease. |
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| Authors: | Rapaka D; A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, India. Electronic address: deepthirapaka7@gmail.com.; Bitra VR; School of Pharmacy, University of Botswana, P/Bag-0022, Gaborone, Botswana.; Challa SR; Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, Peoria, IL 61614, USA.; Adiukwu PC; School of Pharmacy, University of Botswana, P/Bag-0022, Gaborone, Botswana. |
| Source: | Neuropeptides [Neuropeptides] 2021 Dec; Vol. 90, pp. 102196. Date of Electronic Publication: 2021 Sep 02. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8103156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2785 (Electronic) Linking ISSN: 01434179 NLM ISO Abbreviation: Neuropeptides Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2002- : Amsterdam : Elsevier; Original Publication: Edinburgh ; New York : Churchill Livingstone, c1980- |
| MeSH Terms: | Alzheimer Disease/*drug therapy ; Endocannabinoids/*physiology ; Microglia/*drug effects ; Neuroinflammatory Diseases/*drug therapy ; Signal Transduction/*drug effects; Alzheimer Disease/complications ; Cannabinoid Receptor Agonists/pharmacology ; Cannabinoid Receptor Agonists/therapeutic use ; Neuroinflammatory Diseases/etiology ; Aged ; Aged, 80 and over ; Humans ; Macrophage Activation |
| Abstract: | Alzheimer's disease (AD) isaprogressive neurodegenerative disorder characterized by chronic inflammation due to the presence of neurotoxic Aβ and tau proteins. Increased microglial activation and inflated immune response are the other factors to be considered in AD pathology. Microglial cells own biochemical machinery that synthesizes and release endocannabinoids. The exploitation of therapeutic actions of endocannabinoid system has newly emerged in the field of Alzheimer's disease. The activation of cannabinoid receptors/ cannabinoid system modulates inflammatory responses. This review assesses the association between the microglial endocannabinoid system and neuroinflammation in AD. The data supporting the anti-inflammatory role of pharmacological agents modulating cannabinoid system are also reviewed.; (Copyright © 2021 Elsevier Ltd. All rights reserved.) |
| Contributed Indexing: | Keywords: Alzheimer's disease; CB(1)R; CB(2)R; Endocannabinoid; Microglia; Neuroinflammation |
| Substance Nomenclature: | 0 (Cannabinoid Receptor Agonists); 0 (Endocannabinoids) |
| Entry Date(s): | Date Created: 20210911 Date Completed: 20220225 Latest Revision: 20220225 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.npep.2021.102196 |
| PMID: | 34508923 |
| Database: | MEDLINE |
Journal Article; Review