Prevalence of resistance-associated substitutions and phylogenetic analysis of hepatitis C virus infection in Russia.
| Title: | Prevalence of resistance-associated substitutions and phylogenetic analysis of hepatitis C virus infection in Russia. |
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| Authors: | Isakov V; Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russia.; Hedskog C; Gilead Sciences, Inc., Foster City, California, USA.; Wertheim JO; University of California San Diego, San Diego, California, USA.; Hostager RE; University of California San Diego, San Diego, California, USA.; Parhy B; Gilead Sciences, Inc., Foster City, California, USA. Electronic address: bandita.parhy@gilead.com.; Schneider AB; University of California San Diego, San Diego, California, USA.; Suri V; Gilead Sciences, Inc., Foster City, California, USA.; Mo H; Gilead Sciences, Inc., Foster City, California, USA.; Geivandova N; Stavropol State Medical University, Stavropol, Russia.; Morozov V; Hepatolog LLC, Samara, Russia.; Bessonova E; Sverdlovsk Regional Clinical Hospital, Yekaterinburg, Russia.; Gankina N; Krasnoyarsk Regional Center of Prevention and Control of AIDS, Krasnoyarsk, Russia.; Zhdanov K; S.M. Kirov Military Medical Academy, Saint Petersburg, Russia.; Abdurakhmanov D; I.M. Sechenov First Moscow State Medical University, Moscow, Russia.; Svarovskaia E; Gilead Sciences, Inc., Foster City, California, USA. |
| Source: | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2021 Dec; Vol. 113, pp. 36-42. Date of Electronic Publication: 2021 Sep 21. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: Canada NLM ID: 9610933 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3511 (Electronic) Linking ISSN: 12019712 NLM ISO Abbreviation: Int J Infect Dis Subsets: MEDLINE |
| Imprint Name(s): | Publication: Hamilton, ON : Elsevier; Original Publication: Hamilton, ON : Decker, c1996- |
| MeSH Terms: | Hepatitis C*/drug therapy ; Hepatitis C*/epidemiology ; Hepatitis C, Chronic*/drug therapy ; Hepatitis C, Chronic*/epidemiology; Antiviral Agents/therapeutic use ; Hepacivirus/genetics ; Russia/epidemiology ; Viral Nonstructural Proteins/genetics ; Drug Resistance, Viral ; Genotype ; Humans ; Phylogeny ; Prevalence |
| Abstract: | Objectives: Due to limited hepatitis C virus (HCV) sequence availability from patients in Russia, the relationship between subtypes and baseline resistance-associated substitutions (RAS) to direct antiretroviral treatment outcome is not fully understood.; Methods: Deep sequencing of HCV NS3, NS5A, and NS5B sequences was performed on plasma HCV samples from 412 direct-acting antiviral (DAA)-naïve patients from Russia. Phylogenetic analysis was performed to investigate sequence similarities between HCV strains from Russia, Asia, Europe, and North America. Pretreatment HCV RAS was assessed with a 15% cutoff.; Results: HCV genotype GT1b and GT3a sequences in Russia were related to strains in Europe and Asia. The prevalence of GT1a and GT2a was low in Russia. In GT1b, the prevalence of NS5A Y93H was lower in Russia (6%) compared with Asia (15%). The prevalence of NS5B L159F was similar between Russia and Europe (26-39%). GT3a RAS prevalence was similar between Russia and Asia, Europe, and North America. The 2k/1b recombinant strain in Russia was related to strains from Europe. A higher prevalence of the NS5A RAS L31M (10%) was observed in 2k/1b sequences compared to GT1b (1-6%).; Conclusions: The prevalence of RASs and the phylogenetic analysis showed similarities in HCV strains between Russia, Europe, and North America. This information may be useful for HCV regimens in Russia.; (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Contributed Indexing: | Keywords: Direct-acting antivirals; Resistance-associated substitutions; Sequencing |
| Substance Nomenclature: | 0 (Antiviral Agents); 0 (Viral Nonstructural Proteins) |
| Entry Date(s): | Date Created: 20210924 Date Completed: 20211208 Latest Revision: 20211214 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.ijid.2021.09.041 |
| PMID: | 34560266 |
| Database: | MEDLINE |
Journal Article