Allogeneic Hematopoietic Stem Cell Transplant Infusion During Venovenous Extracorporeal Membrane Oxygenation Support.
| Title: | Allogeneic Hematopoietic Stem Cell Transplant Infusion During Venovenous Extracorporeal Membrane Oxygenation Support. |
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| Authors: | Qutob R; Department of Critical Care Medicine, McGill University, Montreal, QC, Canada.; Department of Internal Medicine, Faculty of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia.; Ji X; Department of Internal Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada.; Assanangkornchai N; Department of Critical Care Medicine, McGill University, Montreal, QC, Canada.; Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.; Sapon-Cousineau V; Department of Hematology, McGill University, Montreal, QC, Canada.; Tam M; Perfusion Department, McGill University, Montreal, QC, Canada.; Larotonda R; Nursing Department, McGill University, Montreal, QC, Canada.; Routy JP; Department of Hematology, McGill University, Montreal, QC, Canada.; Popradi G; Department of Hematology, McGill University, Montreal, QC, Canada.; Samoukovic G; Department of Critical Care Medicine, McGill University, Montreal, QC, Canada. |
| Source: | Critical care explorations [Crit Care Explor] 2021 Oct 08; Vol. 3 (10), pp. e551. Date of Electronic Publication: 2021 Oct 08 (Print Publication: 2021). |
| Publication Type: | Case Reports; Journal Article |
| Language: | English |
| Journal Info: | Publisher: Wolters Kluwer Health Country of Publication: United States NLM ID: 101746347 Publication Model: eCollection Cited Medium: Internet ISSN: 2639-8028 (Electronic) Linking ISSN: 26398028 NLM ISO Abbreviation: Crit Care Explor Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Philadelphia, PA : Wolters Kluwer Health, [2019]- |
| Abstract: | Management of hematopoietic stem cell transplant complicated by respiratory failure has been facilitated by the use of extracorporeal membrane oxygenation as a bridge to curative chemotherapeutic options. This is the first report of hematopoietic stem cell transplantation on extracorporeal membrane oxygenation in the adult population.; Case Summary: A 28-year-old woman diagnosed with idiopathic aplastic anemia complicated by acute respiratory distress syndrome secondary to pneumonia required venovenous extracorporeal membrane oxygenation to supplement oxygenation and ventilation. She received hematopoietic stem cell transplantation while she was on extracorporeal membrane oxygenation support.; Main Results and Conclusion: Delivery of the stem cell through extracorporeal membrane oxygenation circuit was successful in the described patient. There was no sequestered stem cell in extracorporeal membrane oxygenation circuit, and she was found to have 90% donor chimerism suggesting successful engraftment. This report showed that infusion of stem cell through extracorporeal membrane oxygenation circuit is safe and feasible, and our results suggest that successful engraftment is possible.; (Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.) |
| Competing Interests: | The authors have disclosed that they do not have any potential conflicts of interest. |
| References: | Indian J Crit Care Med. 2016 Oct;20(10):617-619. (PMID: 27829721); JAMA. 2019 Aug 13;322(6):557-568. (PMID: 31408142); Cureus. 2020 Jul 10;12(7):e9118. (PMID: 32685324); Can Respir J. 2009 Mar-Apr;16(2):e3-5. (PMID: 19399304); Crit Care Med. 2016 Jun;44(6):1082-90. (PMID: 26807683); Blood Adv. 2018 Aug 14;2(15):2020-2028. (PMID: 30108110); Blood Adv. 2020 Apr 28;4(8):1770-1779. (PMID: 32343796); Semin Hematol. 2000 Jan;37(1):30-42. (PMID: 10676909); Intensive Care Med. 2020 Nov;46(11):2048-2057. (PMID: 33021684) |
| Contributed Indexing: | Keywords: acute respiratory distress syndrome; aplastic anemia; engraftment; extracorporeal life support; extracorporeal membrane oxygenation; hematopoietic stem cell transplantation |
| Entry Date(s): | Date Created: 20211015 Latest Revision: 20220427 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC8505339 |
| DOI: | 10.1097/CCE.0000000000000551 |
| PMID: | 34651138 |
| Database: | MEDLINE |
Case Reports; Journal Article