Four Decades of Military Posttraumatic Stress: Protocol for a Meta-analysis and Systematic Review of Treatment Approaches and Efficacy.
| Title: | Four Decades of Military Posttraumatic Stress: Protocol for a Meta-analysis and Systematic Review of Treatment Approaches and Efficacy. |
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| Authors: | Liu JJW; The MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.; Department of Psychiatry, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Nazarov A; The MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.; Department of Psychiatry, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.; Easterbrook B; The MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.; Plouffe RA; The MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.; Department of Psychiatry, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Le T; The MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.; Forchuk C; The MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.; Brandwood A; The MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.; St Cyr K; The MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.; Auger E; Clinique pour traumatismes liés au stress opérationnel, Centre intégré universitaire de santé et de services sociaux de la Capitale-Nationale, Quebec, QC, Canada.; Department of Psychiatry and Neurosciences, Faculty of Medicine, Laval University, Quebec, QC, Canada.; Balderson K; Department of Psychiatry, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; St. Joseph's Operational Stress Injury Clinic, Toronto, ON, Canada.; Bilodeau M; Clinique pour traumatismes liés au stress opérationnel, Centre intégré universitaire de santé et de services sociaux de la Capitale-Nationale, Quebec, QC, Canada.; Department of Psychiatry and Neurosciences, Faculty of Medicine, Laval University, Quebec, QC, Canada.; Burhan AM; Ontario Shores Centre of Mental Health Sciences, Whitby, ON, Canada.; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Enns MW; Department of Psychiatry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.; Winnipeg Operational Stress Injury Clinic, Winnipeg, ON, Canada.; Smith P; Centre of Excellence on Post-Traumatic Stress Disorder and Related Mental Health Conditions, Ottawa, ON, Canada.; Hosseiny F; Centre of Excellence on Post-Traumatic Stress Disorder and Related Mental Health Conditions, Ottawa, ON, Canada.; Dupuis G; Centre of Excellence on Post-Traumatic Stress Disorder and Related Mental Health Conditions, Ottawa, ON, Canada.; Roth M; St. Joseph's Operational Stress Injury Clinic, Toronto, ON, Canada.; Yeates School of Graduate Studies, Ryerson University, Toronto, ON, Canada.; Mota N; Department of Clinical Health Psychology, University of Manitoba, Winnipeg, ON, Canada.; Lavoie V; Clinique pour traumatismes liés au stress opérationnel, Centre intégré universitaire de santé et de services sociaux de la Capitale-Nationale, Quebec, QC, Canada.; Richardson JD; The MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.; Department of Psychiatry, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; St. Joseph's Operational Stress Injury Clinic, London, ON, Canada. |
| Source: | JMIR research protocols [JMIR Res Protoc] 2021 Oct 25; Vol. 10 (10), pp. e33151. Date of Electronic Publication: 2021 Oct 25. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: JMIR Publications Country of Publication: Canada NLM ID: 101599504 Publication Model: Electronic Cited Medium: Print ISSN: 1929-0748 (Print) Linking ISSN: 19290748 NLM ISO Abbreviation: JMIR Res Protoc Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Toronto : JMIR Publications |
| Abstract: | Background: Over 85% of active members of the Canadian Armed Forces have been exposed to potentially traumatic events linked to the development of posttraumatic stress disorder (PTSD). At the time of transition to civilian life, as high as 1 in 8 veterans may be diagnosed with PTSD. Given the high prevalence of PTSD in military and veteran populations, the provision of effective treatment considering their unique challenges and experiences is critical for mental health support and the well-being of these populations.; Objective: This paper presents the protocol for a meta-analysis and systematic review that will examine the effectiveness of treatment approaches for military-related PTSD.; Methods: This PROSPERO-preregistered meta-analysis is being conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and Cochrane guidelines. A comprehensive search of the literature was conducted using the databases PsycInfo, Medline, Embase, CINAHL, and ProQuest Dissertation & Theses. Effect sizes will be computed based on changes in PTSD symptom scores over time across studies using validated PTSD scales. A multilevel meta-analysis will examine the overall effects, between-study effects, and within-study effects of available evidence for PTSD treatments in military populations. Effect sizes will be compared between pharmacotherapeutic, psychotherapeutic, and alternative/emerging treatment interventions. Finally, meta-regression and subgroup analyses will explore the moderating roles of clinical characteristics (eg, PTSD symptom clusters), treatment approaches (eg, therapeutic orientations in psychotherapy and alternative therapies and classifications of drugs in pharmacotherapy), as well as treatment characteristics (eg, length of intervention) on treatment outcomes.; Results: The literature search was completed on April 14, 2021. After the removal of duplicates, a total of 12,002 studies were screened for inclusion. As of July 2021, title and abstract screening has been completed, with 1469 out of 12,002 (12.23%) studies included for full-text review. Full review is expected to be completed in the summer of 2021, with initial results expected for publication by early winter of 2021.; Conclusions: This meta-analysis will provide information on the current state of evidence on the efficacy and effectiveness of various treatment approaches for military-related PTSD and identify factors that may influence treatment outcomes. The results will inform clinical decision-making for service providers and service users. Finally, the findings will provide insights into future treatment development and practice recommendations to better support the well-being of military and veteran populations.; Trial Registration: PROSPERO CRD42021245754; https://tinyurl.com/y9u57c59.; International Registered Report Identifier (irrid): DERR1-10.2196/33151.; (©Jenny J W Liu, Anthony Nazarov, Bethany Easterbrook, Rachel A Plouffe, Tri Le, Callista Forchuk, Alec Brandwood, Kate St Cyr, Edouard Auger, Ken Balderson, Mathieu Bilodeau, Amer M Burhan, Murray W Enns, Patrick Smith, Fardous Hosseiny, Gabrielle Dupuis, Maya Roth, Natalie Mota, Vicky Lavoie, J Don Richardson. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 25.10.2021.) |
| References: | Dialogues Clin Neurosci. 2015 Jun;17(2):141-50. (PMID: 26246789); Psychiatr Serv. 2004 May;55(5):519-31. (PMID: 15128960); Psychol Assess. 2016 Oct;28(10):1159-1165. (PMID: 26691507); JAMA. 2012 Aug 15;308(7):700-9. (PMID: 22893167); PLoS Med. 2020 Aug 19;17(8):e1003262. (PMID: 32813696); Psychiatr Serv. 2014 May 1;65(5):591-602. (PMID: 24638076); J Gen Intern Med. 2016 Oct;31(10):1206-11. (PMID: 27170304); JMIR Res Protoc. 2020 Oct 29;9(10):e20620. (PMID: 33118957); World Psychiatry. 2019 Oct;18(3):259-269. (PMID: 31496089); Psychol Assess. 2016 Oct;28(10):1166-1171. (PMID: 26691504); Transl Psychiatry. 2020 May 28;10(1):168. (PMID: 32467579); PLoS One. 2017 Jul 25;12(7):e0181647. (PMID: 28742837); Front Behav Neurosci. 2018 Nov 02;12:258. (PMID: 30450043); Front Psychol. 2015 Aug 07;6:1121. (PMID: 26300817); Mil Med. 2009 May;174(5):460-9. (PMID: 20731275); J Trauma Stress. 2011 Aug;24(4):465-9. (PMID: 21793047); J Trauma Stress. 2022 Feb;35(1):66-77. (PMID: 34048602); Focus (Am Psychiatr Publ). 2017 Oct;15(4):411-419. (PMID: 31975872); Can J Psychiatry. 2015 Nov;60(11):488-96. (PMID: 26720506); Perm J. 2014 Winter;18(1):71-7. (PMID: 24626074); Mil Med. 2018 May 1;183(5-6):e223-e231. (PMID: 29415222); P T. 2016 Oct;41(10):623-634. (PMID: 27757001); Assessment. 2017 Jun;24(4):503-516. (PMID: 26603115); BMJ. 2021 Mar 29;372:n71. (PMID: 33782057); J Anxiety Disord. 2019 Oct;67:102133. (PMID: 31472332); Acta Psychiatr Scand. 2018 Apr;137(4):342-354. (PMID: 29504125); Lancet Psychiatry. 2018 Jun;5(6):486-497. (PMID: 29728331); Eur J Psychotraumatol. 2021 Jan 26;12(1):1802920. (PMID: 34992738); Res Synth Methods. 2010 Apr;1(2):97-111. (PMID: 26061376); J Psychother Integr. 2019 Mar;29(1):15-22. (PMID: 31534308); Brain Sci. 2018 Jan 20;8(1):. (PMID: 29361705); Environ Int. 2020 May;138:105623. (PMID: 32203803) |
| Contributed Indexing: | Keywords: Canada; disorder; efficacy; meta-analysis; military; military personnel; pharmacotherapy; posttraumatic; posttraumatic stress disorder; psychotherapy; review; stress; stress disorders; systematic review; therapy; treatment; veteran |
| Entry Date(s): | Date Created: 20211025 Latest Revision: 20231108 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC8576591 |
| DOI: | 10.2196/33151 |
| PMID: | 34694228 |
| Database: | MEDLINE |
Journal Article