Risk Factors, Clinical Manifestations and Treatment Outcomes of Colon Cancer Patients in National Guard Hospital in Jeddah, Saudi Arabia.
| Title: | Risk Factors, Clinical Manifestations and Treatment Outcomes of Colon Cancer Patients in National Guard Hospital in Jeddah, Saudi Arabia. |
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| Authors: | Neazy SA; Medicine, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Jeddah, SAU.; Mikwar Z; Surgical Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, SAU.; Sameer AS; Basic Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Jeddah, SAU.; Quality Unit, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Jeddah, SAU.; Alghamdi K; Medicine, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Jeddah, SAU.; Alowaydhi HM; Medicine, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Jeddah, SAU.; Hashim RT; Diagnostic Radiology, King Abdulaziz University Hospital, Jeddah, SAU.; Salama KH; Medicine, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Jeddah, SAU. |
| Source: | Cureus [Cureus] 2021 Sep 21; Vol. 13 (9), pp. e18150. Date of Electronic Publication: 2021 Sep 21 (Print Publication: 2021). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Palo Alto, CA : Cureus, Inc. |
| Abstract: | Introduction Colon cancer is the third most common cancer worldwide and its incidence is increasing day by day. Provision of early management to cancer patients can lead to a good prognosis. Hence, we evaluated the risk factors, clinical manifestations and treatment outcomes for colon cancer patients in National Guard Health Affairs (NGHA), Jeddah, Saudi Arabia from January 2010 to December 2020 by comparing those results according to their age groups. Methods A retrospective cohort study was performed on 251 colon cancer patients who underwent a surgical procedure. The patients were divided into the following age groups: ≤ 50 (young), 51-60 and > 60 (old) years old. The demographic variables such as age and gender were collected. The results were classified into risk factors, clinical features and treatment outcomes. The comparison between different age groups was made using Chi-square or Fisher's exact test. The data was stored in Excel 2016 (Microsoft Corporation, Redmond, USA) and analyzed using SPSS (IBM Corp, Armonk, USA). Results The results revealed that most patients were males and the median age for diagnosis was 58 years old. There were 15.1% of patients with a positive family history. Moreover, the most common anatomical position was the left side of the colon in all age groups. Most patients had moderately differentiated colon cancer in the histopathological diagnosis. Laparotomy was the most common procedure done to patients in all age groups. There was no difference between all age groups and the aggressiveness of colon cancer. Young patients (≤ 50 years) had a higher percentage to have 5-year recurrence rate (42 % vs 19% vs 25%, p-value 60 years) respectively. However, there was no association between all age groups and 5-year mortality rate (22% vs 9% vs 19%, p-value = 0.171). Conclusion In comparison to old patients (> 60 years), young patients (≤ 50 years) have a more rate of recurrent colon cancer. In relation to all age groups, there were no differences in terms of the aggressive presentation or 5-year mortality rates. In addition, it appears that there were some differences between our study results and worldwide results. This may be because of occupational, cultural and/or genetic variations. Further studies with a higher number of patients and multicenter data collection are highly recommended.; (Copyright © 2021, Neazy et al.) |
| Competing Interests: | The authors have declared that no competing interests exist. |
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| Contributed Indexing: | Keywords: chemotherapy; colon cancer and colon polyps; colon cancer prevention; family history of colon cancer; metastatic colo-rectal cancer |
| Entry Date(s): | Date Created: 20211027 Latest Revision: 20211028 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC8529408 |
| DOI: | 10.7759/cureus.18150 |
| PMID: | 34703688 |
| Database: | MEDLINE |
Journal Article