COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction.
| Title: | COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction. |
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| Authors: | De Luca G; Department of Cardiology, AOU Maggiore della Carità, Eastern Piedmont University, Novara, Italy giuseppe.deluca@med.uniupo.it.; Department of Translational Medicine, Eastern Piedmont University, Novara, Italy.; Algowhary M; Division of Cardiology, Assiut University, Assiut, Egypt.; Uguz B; Division of Cardiology, Bursa City Hospital, Bursa, Turkey.; Oliveira DC; Pronto de Socorro Cardiologico, Centro PROCAPE Prof. Tavares, Recife, Brazil.; Ganyukov V; Department of Heart and Vascular Surgery, Kemerovo Cardiology Center, Кемерово, Russia.; Zimbakov Z; University Clinic for Cardiology, Ss Cyril and Methodius University in Skopje, Skopje, Macedonia.; Cercek M; Centre for Intensive Internal Medicine, University Medical Centre, Ljubljana, Slovenia.; Jensen LO; Division of Cardiology, Odense Universitetshospital, Odense, Denmark.; Loh PH; Department of Cardiology, Singapore Health Service, Singapore.; Calmac L; Clinic Emergency Hospital, University of Bucharest, Bucuresti, Romania.; Roura-Ferrer G; Interventional Cardiology Unit, Bellvitge University Hospital, L'Hospitalet de Llobregat, Spain.; Quadros A; Instituto de Cardiologia, Rio Grande do Sul State Department of Health, Porto Alegre, Brazil.; Milewski M; Division of Cardiology, Medical University of Silesia in Katowice, Katowice, Poland.; Scotto di Uccio F; Division of Cardiology, Ospedale del Mare, Napoli, Italy.; von Birgelen C; Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente, Academisch Medisch Centrum, Twente, The Netherlands.; Versaci F; Department of Cardiology, S Maria Goretti Hospital, Latina, Italy.; Ten Berg J; Department of Cardiology, Sint Antonius Ziekenhuis, Nieuwegein, The Netherlands.; Casella G; Cardiology, Ospedale Maggiore Bologna, Bologna, Italy.; Wong ASL; Cardiology, National Heart Centre Singapore, Singapore.; Kala P; University Hospital Brno, Masaryk University, Brno, Czech Republic.; Diez Gil JL; Department of Cardiology, Hospital Universitari i Politecnic La Fe, Valencia, Spain.; Carrillo X; Department of Cardiology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.; Dirksen MT; Cardiology, Medical Centre Alkmaar, Alkmaar, The Netherlands.; Becerra-Muñoz VM; Department of Cardiology, University Hospital Virgen de la Victoria, Malaga, Spain.; Kang-Yin Lee M; Department of Cardiology, Queen ElizabethHospital University of Hong Kong, Hong Kong, Hong Kong.; Juzar DA; Department of cardiology and Vascular Medicine, National Cardiovascular Center 'Harapan Kita', Jakarta, Indonesia.; de Moura Joaquim R; Instituto de Cardiologia, Santa Catarina Praia Comprida, Sao Jose, Brazil.; Paladino R; Division of Cardiology, Villa dei fiori Srl, Acerra, Italy.; Milicic D; Department of Cardiology, University of Zagreb, Zagreb, Croatia.; Davlouros P; Department of Cardiology, University of Patras, Patras, Greece.; Bakraceski N; Center for Cardiovascular Diseases, Ohrid University Hospital, Ohrid, Macedonia.; Zilio F; Division of Cardiology, Ospedale Santa Chiara di Trento, Trento, Italy.; Donazzan L; Cardiology, Ospedale di Bolzano, Bolzano, Italy.; Kraaijeveld AO; Division of Cardiology, Utrecht University, Utrecht, The Netherlands.; Galasso G; Division of Cardiology, University of Salerno, Salerno, Italy.; Lux A; Cardiology, Maastricht University Hospital, Maastricht, The Netherlands.; Marinucci L; Division of Cardiology, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', Ancona, Italy.; Guiducci V; Division of Cardiology, ASL 3 Reggio Emilia, Reggio Emilia, Italy.; Menichelli M; Cardiology Division, Ospedale Fabrizio Spaziani, Roma, Italy.; Cardiology Division, Ospedale 'F. Spaziani', Frosinone, Italy.; Scoccia A; Division of Cardiology, Ospedale S. Anna Ferrara, Ferrara, Italy.; Yamac A; Department of Cardiology, Bezmialem Vakıf University İstanbul, Istanbul, Turkey.; Ugur Mert K; Division of Cardiology, Eskisehir Osmangazi Universitesi, Eskisehir, Turkey.; Flores Rios X; Complexo Hospetaliero Universitario, La Coruna, La Coruna, Spain.; Kovarnik T; Department of Cardiovascular Medicine, University Hospital Prague, Prague, Czech Republic.; Kidawa M; Central Hospital, Medical University of Lodz, Lodz, Poland.; Moreu J; Division of Cardiology, Hospital Complex of Toledo, Toledo, Spain.; Flavien V; Division of Cardiology, Lille University Hospital Center, Lille, France.; Fabris E; Department of Cardiology, Universita degli Studi di Trieste Dipartimento di Scienze Mediche Chirurgiche e della Salute, Trieste, Italy.; Lozano Martìnez-Luengas I; Division of Cardiology, Hospital de Cabueñes, Gijon, Spain.; Boccalatte M; Division of Cardiology, Ospedale Santa Maria delle Grazie, Pozzuoli, Naples, Italy.; Bosa Ojeda F; Division of Cardiology, Consorcio Sanitario de Tenerife, Santa Cruz de Tenerife, Spain.; Arellano-Serrano C; Division of Cardiology, Hospital Puerta de Hierro Mahadahonda, Barcelona, Spain.; Caiazzo G; Division of Cardiology, Ospedale 'G Moscati', Aversa, Aversa, Italy.; Cirrincione G; Division of Cardiology, Ospedale Civico Arnas, Palermo, Italy.; Kao HL; Cardiology Division, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Sanchis Fores J; Department of Cardiology, Hospital Clinico Universitario, Universidad de Valencia, Valencia, Spain.; Vignali L; Interventional Cardiology Unit, Azienda Ospedaliera Sanitaria, Parma, Parma, Italy.; Pereira H; Cardiology Department, Garcia de Orta Hospital, Almada, Portugal.; Manzo-Silberman S; Department of Cardiology, INSERM Délégation Régionale Paris 7, Bagnolet, France.; Ordonez S; Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.; Özkan AA; Cardiology Institute, Istanbul University, Istanbul, Turkey.; Scheller B; Clinical and Experimental Interventional Cardiology, Saarland University, Saarbrucken, Germany.; Lehtola H; Division of Cardiology, Oulu University Hospital, Oulu, Finland.; Teles R; Department of Cardiology, Hospital de Santa Cruz, CHLO - Nova Medical School,CEDOC, Carnaxide, Portugal.; Mantis C; Division of Cardiology, Kontantopoulion Hospital, Athens, Athens, Greece.; Ylitalo A; Division of Cardiology, Heart Centre Turku, Turku, Finland.; Brum Silveira JA; Division of Cardiology, Hospital de Santo António, Porto, Portugal.; Zoni R; Instituto de Cardiología de Corrientes Juana Francisca Cabral, Corrientes, Argentina.; Bessonov I; Cardiology, Tyumen Research Centre, Tyumen, Russia.; Savonitto S; Cardiology, Ospedale Alessandro Manzoni, Lecco, Italy.; Kochiadakis G; Division of Cardiology, Iraklion University Hospital, Heraklion, Greece.; Alexopoulos D; Division of Cardiology, Attikon Clinic, Athens, Greece.; Uribe C; Division of Cardiology, Medellin Clinic Universidad UPB, Medellin, Colombia.; Kanakakis J; Division of Cardiology, General Hospital of Athens Alexandra, Athens, Greece.; Faurie B; Division of Cardiology, Groupe Hospitalier Mutualiste de Grenoble, Grenoble, France.; Gabrielli G; SOD Cardiologia-Emodinamica-UTIC, Azienda Ospedali Riuniti - Presidio 'GM Lancisi', Ancona, Italy.; Gutiérrez A; Hospital Universitario Puerta del Mar Servicio de Cardiología, Cadiz, Spain.; Bachini JP; Instituto de Cardiologia Integral, Montevideo, Uruguay.; Rocha A; Department of Cardiology and Cardiovascular Interventions, Instituto Nacional de Cirugía Cardíaca, Montevideo, Uruguay.; Tam FC; Department of Cardiology, Queen Mary Hospital, Hong Kong, Hong Kong.; Rodriguez A; Department of Cardiology, Otamendi Hospital, Buenos Aires, Argentina.; Lukito A; Cardiovascular Department, Pelita Harapan University, Tangerang, Indonesia.; Saint-Joy V; Centre Hospitalier d Antibes Juan les Pins, Antibes, France.; Pessah G; Division of Cardiology, Cordoba Hospital, Cordoba, Argentina.; Tuccillo B; Division of Cardiology, Ospedale del Mare, Napoli, Italy.; Cortese G; Department of Statistical Sciences, University of Padova, Padova, Italy.; Parodi G; Division of cardiology, Sassari University Hospital, Sassari, Italy.; Bouraghda MA; Division of cardiology, Blida University Hospital, Blida, Algeria.; Kedhi E; Cardiology, Hopital Erasmus, Universitè Libre de Bruxelles, Bruxelles, Belgium.; Lamelas P; Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.; Suryapranata H; Cardiology, Radboud UMC, Nijmegen, The Netherlands.; Nardin M; Department of Translational Medicine, Eastern Piedmont University, Novara, Italy.; Ospedali Riuniti, Brescia, Italy.; Verdoia M; Department of Translational Medicine, Eastern Piedmont University, Novara, Italy.; Cardiology, Nuovo Ospedale degli Infermi ASL Biella, Biella, italy. |
| Corporate Authors: | ISACS-STEMI COVID-19; Collaborators |
| Source: | Heart (British Cardiac Society) [Heart] 2022 Mar; Vol. 108 (6), pp. 458-466. Date of Electronic Publication: 2021 Oct 28. |
| Publication Type: | Journal Article; Multicenter Study |
| Language: | English |
| Journal Info: | Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 9602087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-201X (Electronic) Linking ISSN: 13556037 NLM ISO Abbreviation: Heart Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BMJ Pub. Group, c1996- |
| MeSH Terms: | COVID-19*; Cardiologists/*trends ; Percutaneous Coronary Intervention/*trends ; Practice Patterns, Physicians'/*trends ; ST Elevation Myocardial Infarction/*therapy ; Time-to-Treatment/*trends; Hospital Mortality/trends ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/mortality ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/mortality ; Aged ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Registries ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome |
| Abstract: | Objective: The initial data of the International Study on Acute Coronary Syndromes - ST Elevation Myocardial Infarction COVID-19 showed in Europe a remarkable reduction in primary percutaneous coronary intervention procedures and higher in-hospital mortality during the initial phase of the pandemic as compared with the prepandemic period. The aim of the current study was to provide the final results of the registry, subsequently extended outside Europe with a larger inclusion period (up to June 2020) and longer follow-up (up to 30 days).; Methods: This is a retrospective multicentre registry in 109 high-volume primary percutaneous coronary intervention (PPCI) centres from Europe, Latin America, South-East Asia and North Africa, enrolling 16 674 patients with ST segment elevation myocardial infarction (STEMI) undergoing PPPCI in March/June 2019 and 2020. The main study outcomes were the incidence of PPCI, delayed treatment (ischaemia time >12 hours and door-to-balloon >30 min), in-hospital and 30-day mortality.; Results: In 2020, during the pandemic, there was a significant reduction in PPCI as compared with 2019 (incidence rate ratio 0.843, 95% CI 0.825 to 0.861, p75 years) (p=0.015), and was not related to the peak of cases or deaths due to COVID-19. The heterogeneity among centres was high (p |
| Competing Interests: | Competing interests: None declared. |
| Comments: | Comment in: Heart. 2022 Mar;108(6):412-413. doi: 10.1136/heartjnl-2021-320383.. (PMID: 35078870); Comment in: Heart. 2022 Mar;108(6):407-409. doi: 10.1136/heartjnl-2022-320938.. (PMID: 35210290) |
| Contributed Indexing: | Investigator: T Johnson; T Kinnaird; Y Cottin; A Ijsselmuiden; KJ Royaards; M Siviglia; G Amoroso; A Banning; A Santucci; L Spedicato; J Mehilli; S Levesque; P Ludman; P Deharo; E Benit; P Agostoni; S Camacho-Freiere; M Brouwer; C Camaro; B Wilbert; P Smits; M Laine; R Moreno; Keywords: COVID-19; myocardial infarction; percutaneous coronary intervention |
| Molecular Sequence: | ClinicalTrials.gov NCT04412655 |
| Entry Date(s): | Date Created: 20211029 Date Completed: 20220303 Latest Revision: 20230829 |
| Update Code: | 20260130 |
| DOI: | 10.1136/heartjnl-2021-319750 |
| PMID: | 34711661 |
| Database: | MEDLINE |
Journal Article; Multicenter Study