Measurement of IgE to hazelnut allergen components cannot replace hazelnut challenge in Dutch adults.
| Title: | Measurement of IgE to hazelnut allergen components cannot replace hazelnut challenge in Dutch adults. |
|---|---|
| Authors: | Lyons SA; Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Welsing PMJ; Division of internal medicine and dermatology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Hakobyan M; Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Kansen HM; Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Department of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, the Netherlands.; Knol EF; Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Center of Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.; Otten HG; Center of Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.; van Ree R; Department of experimental immunology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.; Department of otorhinolaryngology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.; Knulst AC; Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Center of Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.; Le TM; Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Center of Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands. |
| Source: | Allergy [Allergy] 2022 May; Vol. 77 (5), pp. 1559-1569. Date of Electronic Publication: 2021 Nov 16. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 7804028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1398-9995 (Electronic) Linking ISSN: 01054538 NLM ISO Abbreviation: Allergy Subsets: MEDLINE |
| Imprint Name(s): | Publication: Copenhagen : Wiley-Blackwell; Original Publication: Copenhagen, Munksgaard. |
| MeSH Terms: | Corylus*/adverse effects ; Nut Hypersensitivity*/diagnosis; Allergens ; Antigens, Plant ; Humans ; Immunoglobulin E ; Plant Extracts |
| Abstract: | Background: Component-resolved diagnostics (CRD) help predict hazelnut allergy (HA) in children, but are of unknown diagnostic value in adults. This study aimed to evaluate the diagnostic accuracy of IgE to hazelnut extract and components in adults.; Methods: A Dutch population of consecutively presenting adults suspected of HA, who underwent a double-blind placebo-controlled food challenge, were included. Serum IgE to hazelnut extract and Cor a 1, 8, 9, and 14 was measured on ImmunoCAP. Diagnostic accuracy was assessed by area under the curve (AUC) analysis.; Results: Of 89 patients undergoing challenge, 46 had challenge-confirmed HA: 17 based on objective and 29 based on subjective symptoms. At commonly applied cutoffs 0.1 and 0.35 kUA /L, high sensitivity was observed for IgE to hazelnut extract and Cor a 1 (range 85-91%), and high specificity for IgE to Cor a 8, 9 and 14 (range 77-95%). However, the AUCs for hazelnut extract and components were too low for accurate prediction of HA (range 0.50-0.56). Combining hazelnut extract and component IgE measurements did not significantly improve accuracy. Higher IgE levels to Cor a 9 and 14 were tentatively associated with HA with objective symptoms, but the corresponding AUCs still only reached 0.68 and 0.63, respectively.; Conclusions: Although hazelnut allergic adults are generally sensitized to hazelnut extract and Cor a 1, and hazelnut tolerant adults are usually not sensitized to Cor a 8, 9, or 14, challenge testing is still needed to accurately discriminate between presence and absence of HA in adults from a birch-endemic country.; (© 2021 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.) |
| References: | Nutrients. 2018 Oct 16;10(10):. (PMID: 30332840); Clin Mol Allergy. 2015 Apr 15;13(1):5. (PMID: 25878561); Curr Allergy Asthma Rep. 2016 Mar;16(3):23. (PMID: 26892721); J Allergy Clin Immunol Pract. 2017 Mar - Apr;5(2):237-248. (PMID: 28283150); Cytometry B Clin Cytom. 2005 Mar;64(1):28-33. (PMID: 15668987); J Allergy Clin Immunol Pract. 2019 Jul - Aug;7(6):1920-1928.e11. (PMID: 30898689); Crit Rev Food Sci Nutr. 2016 Nov 17;56(15):2579-2605. (PMID: 25751378); J Allergy Clin Immunol. 2009 May;123(5):1134-41, 1141.e1-3. (PMID: 19344939); Clin Exp Allergy. 2004 May;34(5):689-95. (PMID: 15144458); Allergy. 2016 Apr;71(4):556-62. (PMID: 26666993); Clin Exp Allergy. 2015 Sep;45(9):1412-8. (PMID: 25707509); J Allergy Clin Immunol. 2011 Mar;127(3):616-22.e1. (PMID: 21251701); Allergy. 2015 Sep;70(9):1079-90. (PMID: 26095197); J Allergy Clin Immunol. 2006 Aug;118(2):481-8. (PMID: 16890775); J Allergy Clin Immunol. 2017 Oct;140(4):974-977. (PMID: 28552762); Int Arch Allergy Immunol. 2014;164(3):200-6. (PMID: 25034302); Int Arch Allergy Immunol. 2019;178(1):89-92. (PMID: 30212813); J Allergy Clin Immunol. 1997 Oct;100(4):444-51. (PMID: 9338535); Allergy. 2018 Mar;73(3):549-559. (PMID: 28986984); Allergy. 2015 Jan;70(1):90-8. (PMID: 25308885); Ann Allergy Asthma Immunol. 2020 May;124(5):466-472. (PMID: 32044450); J Allergy Clin Immunol Pract. 2013 Nov-Dec;1(6):632-8.e1. (PMID: 24565711); Allergy. 2014 Aug;69(8):1008-25. (PMID: 24909706); Allergy. 2008 Jul;63(7):793-6. (PMID: 18489614); Allergy. 2015 Mar;70(3):265-74. (PMID: 25476979); Pediatr Allergy Immunol. 2016 May;27 Suppl 23:1-250. (PMID: 27288833); Pediatr Allergy Immunol. 2016 May;27(3):322-4. (PMID: 26680531); Curr Allergy Asthma Rep. 2015 Sep;15(9):54. (PMID: 26233427); Allergy. 2017 Apr;72(4):562-569. (PMID: 27588729); J Allergy Clin Immunol. 2013 Aug;132(2):393-9. (PMID: 23582909); J Allergy Clin Immunol. 2015 Aug;136(2):382-91. (PMID: 25772593); Allergy. 2022 May;77(5):1559-1569. (PMID: 34731517); Curr Opin Allergy Clin Immunol. 2020 Oct;20(5):459-464. (PMID: 32842037); Allergy. 2004 Jul;59(7):690-7. (PMID: 15180754); Biometrics. 1988 Sep;44(3):837-45. (PMID: 3203132); Eur J Clin Nutr. 2001 Apr;55(4):298-304. (PMID: 11360135); J Allergy Clin Immunol Pract. 2021 Apr;9(4):1667-1674.e3. (PMID: 33248282); Pediatr Allergy Immunol. 2020 Feb;31(2):186-196. (PMID: 31301691); J Allergy Clin Immunol Pract. 2016 Mar-Apr;4(2):265-72.e3. (PMID: 26843406) |
| Contributed Indexing: | Keywords: IgE; adults; component-resolved diagnostics; diagnostic value; hazelnut allergy |
| Substance Nomenclature: | 0 (Allergens); 0 (Antigens, Plant); 0 (Plant Extracts); 37341-29-0 (Immunoglobulin E) |
| Entry Date(s): | Date Created: 20211103 Date Completed: 20220502 Latest Revision: 20220731 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9298907 |
| DOI: | 10.1111/all.15166 |
| PMID: | 34731517 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't