Dietary lipids from body to brain.
| Title: | Dietary lipids from body to brain. |
|---|---|
| Authors: | Custers; Department of Medical Imaging, Anatomy, Radboud university medical center, Donders Institute for Brain Cognition and Behaviour, Nijmegen, the Netherlands.; Emma EM; Department of Medical Imaging, Anatomy, Radboud university medical center, Donders Institute for Brain Cognition and Behaviour, Nijmegen, the Netherlands.; Kiliaan; Department of Medical Imaging, Anatomy, Radboud university medical center, Donders Institute for Brain Cognition and Behaviour, Nijmegen, the Netherlands.; Amanda J; Department of Medical Imaging, Anatomy, Radboud university medical center, Donders Institute for Brain Cognition and Behaviour, Nijmegen, the Netherlands. Electronic address: Amanda.Kiliaan@Radboudumc.nl. |
| Source: | Progress in lipid research [Prog Lipid Res] 2022 Jan; Vol. 85, pp. 101144. Date of Electronic Publication: 2021 Dec 13. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Pergamon Country of Publication: England NLM ID: 7900832 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2194 (Electronic) Linking ISSN: 01637827 NLM ISO Abbreviation: Prog Lipid Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: Oxford : Pergamon; Original Publication: Oxford; Elmsford, N. Y., Pergamon Press. |
| MeSH Terms: | Dietary Fats* ; Neuroinflammatory Diseases*; Brain ; Fatty Acids ; Fatty Acids, Monounsaturated ; Humans |
| Abstract: | Dietary habits have drastically changed over the last decades in Western societies. The Western diet, rich in saturated fatty acids (SFA), trans fatty acids (TFA), omega-6 polyunsaturated fatty acids (n-6 PUFA) and cholesterol, is accepted as an important factor in the development of metabolic disorders, such as obesity and diabetes type 2. Alongside these diseases, nutrition is associated with the prevalence of brain disorders. Although clinical and epidemiological studies revealed that metabolic diseases and brain disorders might be related, the underlying pathology is multifactorial, making it hard to determine causal links. Neuroinflammation can be a result of unhealthy diets that may cause alterations in peripheral metabolism. Especially, dietary fatty acids are of interest, as they act as signalling molecules responsible for inflammatory processes. Diets rich in n-6 PUFA, SFA and TFA increase neuroinflammation, whereas diets rich in monounsaturated fatty acids (MUFA), omega-3 (n-3) PUFA and sphingolipids (SL) can diminish neuroinflammation. Moreover, these pro- and anti-inflammatory diets might indirectly influence neuroinflammation via the adipose tissue, microbiome, intestine and vasculature. Here, we review the impact of nutrition on brain health. In particular, we will discuss the role of dietary lipids in signalling pathways directly applicable to inflammation and neuronal function.; (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Contributed Indexing: | Keywords: Dietary lipids; Microbiota; Neurodegenerative diseases; Neuroinflammation; Obesity; White adipose tissue |
| Substance Nomenclature: | 0 (Dietary Fats); 0 (Fatty Acids); 0 (Fatty Acids, Monounsaturated) |
| Entry Date(s): | Date Created: 20211216 Date Completed: 20220128 Latest Revision: 20220128 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.plipres.2021.101144 |
| PMID: | 34915080 |
| Database: | MEDLINE |
Journal Article; Review