Potential role of embelin in the prevention of Freund's adjuvant induced inflammation and ROS.
| Title: | Potential role of embelin in the prevention of Freund's adjuvant induced inflammation and ROS. |
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| Authors: | Kumaraswamy HM; Laboratory of Experimental Medicine, Department of Biotechnology, Kuvempu University, Shimoga, Shankarghatta, Karnataka 577451 India.; Krishna V; Laboratory of Experimental Medicine, Department of Biotechnology, Kuvempu University, Shimoga, Shankarghatta, Karnataka 577451 India.; Sharath R; Department of Food Technology, Davangere University, Shivagangothri, Davangere, Karnataka 577002 India.; Satyanarayan ND; Department of Studies and Research in Pharmaceutical Chemistry, Kuvempu University P.G Centre, Kadur, Karnataka 577548 India.; Meghana P; Laboratory of Experimental Medicine, Department of Biotechnology, Kuvempu University, Shimoga, Shankarghatta, Karnataka 577451 India.; Jain RSK; Laboratory of Experimental Medicine, Department of Biotechnology, Kuvempu University, Shimoga, Shankarghatta, Karnataka 577451 India.; Prashanth N; Laboratory of Experimental Medicine, Department of Biotechnology, Kuvempu University, Shimoga, Shankarghatta, Karnataka 577451 India.; Raja Naika H; Department of Biotechnology, Tumkur University, Tumkur, Karnataka 572103 India. |
| Source: | 3 Biotech [3 Biotech] 2022 Jan; Vol. 12 (1), pp. 10. Date of Electronic Publication: 2021 Dec 08. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Springer Country of Publication: Germany NLM ID: 101565857 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2190-572X (Print) Linking ISSN: 21905738 NLM ISO Abbreviation: 3 Biotech Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Berlin : Springer |
| Abstract: | Inflammation is a complex biological response involving immune cells to an infection creating injury to the normal tissues. The anti-inflammatory efficacy of embelin, a benzoquinone from the plant Embelia ribes, was screened for antioxidant and anti-inflammatory activity in carrageenan and Freund's adjuvant-induced inflammation models. Embelin exhibited significant dose-dependent antioxidant potential. In carrageenan-induced inflammation, embelin (20 mg/kg) showed an inhibition of oedema by 71.01 ± 0.12% and 81.91 ± 0.67% in Freund's adjuvant-treated chronic inflammation model and resulted in a noticeable increase in adrenal size and restoration of the weight of spleen. Embelin also demonstrated cytoprotective effects on HEK-293 cells under induced oxidative stress. In silico analysis, embelin demonstrated binding energy of - 7.7 kcal/Mol and - 7.0 kcal/Mol with COX1 and COX2 with two hydrogen bonds. These results further prove that embelin could be a promising anti-inflammatory agent and supports the traditional use of Embelia ribes for rheumatism.; (© King Abdulaziz City for Science and Technology 2021.) |
| Competing Interests: | Conflict of interestAuthors declare no conflict of interest. |
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| Contributed Indexing: | Keywords: Carrageenan; Embelin; Freund’s adjuvant; Inflammation; Reactive oxygen species |
| Entry Date(s): | Date Created: 20211230 Latest Revision: 20230102 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC8655053 |
| DOI: | 10.1007/s13205-021-03071-5 |
| PMID: | 34966633 |
| Database: | MEDLINE |
Journal Article