Risk factors preceding new onset abuse among youth with bipolar disorder: A longitudinal prospective analysis.
| Title: | Risk factors preceding new onset abuse among youth with bipolar disorder: A longitudinal prospective analysis. |
|---|---|
| Authors: | Andreu-Pascual M; Department of Psychiatry, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA; Child and Adolescent Psychiatry and Psychology Department. Hospital Sant Joan de Déu Barcelona, Spain. Passeig Sant Joan de Déu, 2, 08950 Esplugues de Llobregat, Spain. Electronic address: andreupascual1988@gmail.com.; Merranko J; Department of Psychiatry, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.; Gill MK; Department of Psychiatry, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.; Levenson JC; Department of Psychiatry, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.; Hafeman D; Department of Psychiatry, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.; Hower H; Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G-BH, Providence, RI 02912, USA; Department of Health Services, Policy, and Practice, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA; Department of Psychiatry, School of Medicine, University of California at San Diego, 4510 Executive Drive, Suite 315, San Diego, CA 92121, USA.; Yen S; Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G-BH, Providence, RI 02912, USA; Massachusetts Mental Health Center and the Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.; Strober M; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, 760 Westwood Plaza, Mail Code 175919, Los Angeles, CA 90095, USA.; Goldstein BI; Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto Faculty of Medicine, 2075 Bayview Ave., FG-53, Toronto, ON M4N-3M5, Canada.; Diler R; Department of Psychiatry, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.; Ryan ND; Department of Psychiatry, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.; Weinstock LM; Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G-BH, Providence, RI 02912, USA; Butler Hospital, 700 Butler Drive, Providence, RI 02906, USA.; Keller MB; Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G-BH, Providence, RI 02912, USA; Butler Hospital, 700 Butler Drive, Providence, RI 02906, USA.; Axelson D; Department of Psychiatry, Nationwide Children's Hospital and The Ohio State College of Medicine, 1670 Upham Dr., Columbus, OH 43210, USA.; Birmaher B; Department of Psychiatry, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.; Goldstein TR; Department of Psychiatry, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA. |
| Source: | Journal of affective disorders [J Affect Disord] 2022 Mar 01; Vol. 300, pp. 296-304. Date of Electronic Publication: 2022 Jan 03. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| MeSH Terms: | Bipolar Disorder*/epidemiology ; Bipolar Disorder*/psychology ; Child Abuse*/psychology; Adolescent ; Child ; Comorbidity ; Female ; Humans ; Retrospective Studies ; Risk Factors |
| Abstract: | Background: Childhood abuse negatively impacts the course of Bipolar Disorder (BD). Yet, no study has examined risk factors associated with prospectively evaluated physical/sexual abuse, specifically, those preceding first abuse among BD youth. We investigate past/intake/follow-up factors preceding first physical/sexual abuse among BD youth.; Methods: Childhood-onset BD participants (n = 279 youth, mean age at intake = 12, mean length of follow-up = 12 years) enrolled in the Course and Outcome of Bipolar Youth (COBY) study. Demographic, clinical and family history variables were assessed every 7 months on average using Longitudinal Interval Follow-up Evaluation and Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS-PL). Abuse was evaluated at intake using the K-SADS-PL, over follow-up with a Traumatic Events Screen. Family psychopathology was assessed using Family History Screen/Structured Clinical Interview for Diagnostic Statistical Manual-IV.; Results: Fifteen-percent of youth reported new-onset abuse during follow-up (62% physical, 26% sexual; 12% both). Intake predictors included more severe depressive symptoms (HR = 1.29), low socioeconomic-status (SES) in families with substance abuse (HR = 0.84) (physical abuse), and female sex (HR = 2.41) (sexual abuse). Follow-up predictors preceding physical abuse included: older age (HR = 1.42), disruptive disorders (HR = 1.39), and the interaction between low SES and family substance abuse (HR = 0.86). For sexual abuse, female sex (HR = 4.33) and a non-biologically related father presence in the household (HR = 2.76). Good relationships with friends (prospectively evaluated) protected against physical/sexual abuse (HR = 0.72/0.70, respectively).; Limitations: Prospective data was gathered longitudinally but assessed retrospectively at every follow-up; perpetrator information and abuse severity were not available.; Conclusions: Identifying factors temporally preceding new onset physical/sexual abuse may hold promise for identifying high-risk youth with BD.; (Copyright © 2022 Elsevier B.V. All rights reserved.) |
| References: | Child Abuse Negl. 2006 May;30(5):497-522. (PMID: 16701895); Arch Gen Psychiatry. 2000 Jul;57(7):675-82. (PMID: 10891038); Lancet Psychiatry. 2016 Apr;3(4):342-9. (PMID: 26873185); Child Abuse Negl. 1997 Jan;21(1):49-58. (PMID: 9023022); Med Sci Law. 2015 Oct;55(4):259-77. (PMID: 25107943); Child Abuse Negl. 1996 Mar;20(3):191-203. (PMID: 8734549); Arch Gen Psychiatry. 2006 Oct;63(10):1139-48. (PMID: 17015816); J Affect Disord. 2000 Apr;58(1):79-86. (PMID: 10760562); J Am Acad Child Adolesc Psychiatry. 1997 Jul;36(7):980-8. (PMID: 9204677); Arch Gen Psychiatry. 1987 Jun;44(6):540-8. (PMID: 3579500); J Affect Disord. 2017 Apr 15;213:44-50. (PMID: 28189964); Clin Psychol Rev. 2013 Jun;33(4):561-73. (PMID: 23563080); J Affect Disord. 2019 Oct 1;257:396-403. (PMID: 31306990); J Am Acad Child Adolesc Psychiatry. 2018 Sep;57(9):637-644. (PMID: 30196867); Int J Bipolar Disord. 2020 Mar 2;8(1):10. (PMID: 32115670); Trauma Violence Abuse. 2020 Oct;21(4):660-677. (PMID: 30033824); Child Abuse Negl. 2008 Jul;32(7):682-92. (PMID: 18638626); Trauma Violence Abuse. 2020 Oct;21(4):828-843. (PMID: 30249161); Child Abuse Negl. 2014 Apr;38(4):706-22. (PMID: 24075569); Br J Psychiatry. 2017 Feb;210(2):96-104. (PMID: 27908895); Biol Psychiatry. 2002 Feb 15;51(4):288-97. (PMID: 11958779); J Abnorm Child Psychol. 2015 Apr;43(3):453-63. (PMID: 25118660); Pediatrics. 2007 Sep;120(3):640-5. (PMID: 17766537); Aust N Z J Psychiatry. 2014 Nov;48(11):1017-24. (PMID: 25122448); J Affect Disord. 2009 Jan;112(1-3):144-50. (PMID: 18538857); J Psychiatr Res. 2018 Jan;96:57-64. (PMID: 28965006); Acta Psychiatr Scand. 2011 Dec;124(6):427-34. (PMID: 21848703); Pediatrics. 2009 Nov;124(5):1411-23. (PMID: 19805459); J Child Adolesc Psychopharmacol. 2003 Winter;13(4):463-70. (PMID: 14977459); Child Psychiatry Hum Dev. 2017 Apr;48(2):248-259. (PMID: 27002816); Stat Med. 2018 Jun 30;37(14):2252-2266. (PMID: 29682776); Am J Psychiatry. 2014 Sep;171(9):990-9. (PMID: 24874203); Arch Gen Psychiatry. 1983 Nov;40(11):1228-31. (PMID: 6639293); Bipolar Disord. 2013 Jun;15(4):341-58. (PMID: 23346867); Bipolar Disord. 2000 Sep;2(3 Pt 2):281-93. (PMID: 11249806); J Affect Disord. 2006 Apr;91(2-3):181-8. (PMID: 16478633); Acta Psychiatr Scand. 2005 May;111(5):380-3. (PMID: 15819732); J Affect Disord. 2020 Sep 1;274:126-135. (PMID: 32469795); Br J Psychiatry. 1995 May;166(5):654-9. (PMID: 7620753); Arch Gen Psychiatry. 1985 Jul;42(7):696-702. (PMID: 4015311); J Affect Disord. 2019 Mar 15;247:114-119. (PMID: 30660020); Br J Psychiatry. 2016 Dec;209(6):454-459. (PMID: 27758835); Bipolar Disord. 2010 May;12(3):244-52. (PMID: 20565431); J Affect Disord. 2005 Dec;89(1-3):57-67. (PMID: 16213029); Am J Prev Med. 2019 Jun;56(6):774-786. (PMID: 31104722); Child Maltreat. 2016 Feb;21(1):3-15. (PMID: 26590238); Braz J Psychiatry. 2015 Nov 24;38(2):127-34. (PMID: 26603131); Community Ment Health J. 2005 Feb;41(1):67-75. (PMID: 15932053); J Subst Abuse Treat. 1993 Nov-Dec;10(6):537-43. (PMID: 8308938) |
| Grant Information: | R01 MH059691 United States MH NIMH NIH HHS; R01 MH059929 United States MH NIMH NIH HHS; R01 MH112544 United States MH NIMH NIH HHS; K23 HD087433 United States HD NICHD NIH HHS; R01 MH112543 United States MH NIMH NIH HHS; R01 MH059977 United States MH NIMH NIH HHS |
| Contributed Indexing: | Keywords: Bipolar disorder; Physical abuse; Prospective study; Risk factor; Sexual abuse; Youth |
| Entry Date(s): | Date Created: 20220106 Date Completed: 20220304 Latest Revision: 20231027 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10601969 |
| DOI: | 10.1016/j.jad.2022.01.003 |
| PMID: | 34990625 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't