Tongue muscle mass is associated with total grey matter and hippocampal volumes in Dementia with Lewy Bodies.
| Title: | Tongue muscle mass is associated with total grey matter and hippocampal volumes in Dementia with Lewy Bodies. |
|---|---|
| Authors: | Borda MG; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital. Stavanger, Norway; Semillero de Neurociencias y Envejecimiento, Ageing Institute, Medical School, Pontificia Universidad Javeriana, Bogotá, Colombia; Faculty of Health Sciences, University of Stavanger, Stavanger, Norway. Electronic address: mmborda@gmail.com.; Castellanos-Perilla N; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital. Stavanger, Norway; Semillero de Neurociencias y Envejecimiento, Ageing Institute, Medical School, Pontificia Universidad Javeriana, Bogotá, Colombia.; Tovar-Rios DA; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital. Stavanger, Norway; Faculty of Health Sciences, University of Stavanger, Stavanger, Norway; Universidad del Valle, School of Statistics, Santiago de Cali, Colombia.; Ferreira D; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Duque G; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia; Australian Institute for Musculoskeletal Science (AIMSS), Geroscience and Osteosarcopenia Research Program, The University of Melbourne and Western Health, St. Albans, Melbourne, Victoria, Australia.; Aarsland D; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital. Stavanger, Norway; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK. |
| Source: | Archives of gerontology and geriatrics [Arch Gerontol Geriatr] 2022 May-Jun; Vol. 100, pp. 104647. Date of Electronic Publication: 2022 Feb 01. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Elsevier Biomedical Press Country of Publication: Netherlands NLM ID: 8214379 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6976 (Electronic) Linking ISSN: 01674943 NLM ISO Abbreviation: Arch Gerontol Geriatr Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier Biomedical Press, c1982- |
| MeSH Terms: | Alzheimer Disease*/diagnostic imaging ; Lewy Body Disease*/diagnostic imaging; Atrophy/metabolism ; Atrophy/pathology ; Gray Matter/diagnostic imaging ; Gray Matter/metabolism ; Gray Matter/pathology ; Hippocampus/diagnostic imaging ; Hippocampus/metabolism ; Muscles/metabolism ; Tongue/diagnostic imaging ; Aged ; Cross-Sectional Studies ; Humans |
| Abstract: | Background: Age-related neurodegeneration, sarcopenia, and ectopic fat accumulation are conditions with shared pathways that remain poorly understood. We have measured muscle volume and fat accumulation in masseter and tongue muscle, and aim to explore their association with the total grey matter volume using MRI in older adults recently diagnosed with Alzheimer's disease (AD) and Dementia with Lewy bodies (DLB).; Methods: In this cross-sectional study, people newly diagnosed with mild AD (n=33) and DLB (n=20) underwent structural head MRI. Muscle volume and intramuscular fat (iMAT) of the tongue and masseter were computed using Slice-O-Matic software for segmentation. Total grey volume and hippocampal volumetric segmentation were performed with the FreeSurfer image analysis suite version 6.0. Independent regression models were employed to analyse the associations.; Results: Tongue iMAT was higher and total grey volume lower in DLB compared to AD. In the DLB group, tongue muscle was positively associated with total grey matter volume Est 0.92 (SE 0.24 p-value 0.002), left- Est 0.01 (SE 0.0028 p-value 0,002), and right- Est 0.0088 (SE 0.0027 p-value: 0.005) hippocampal volume. There were no statistically significant results for AD.; Conclusion: Tongue muscle volume was positively associated with hippocampal and total grey volume in DLB. Longitudinal designs are required to explore the extent and significance of this association.; (Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| Grant Information: | United Kingdom DH_ Department of Health |
| Contributed Indexing: | Keywords: Alzheimer's disease; Dementia; Dementia with Lewy Bodies; Intramuscular fat; Muscle; Sarcopenia |
| Entry Date(s): | Date Created: 20220208 Date Completed: 20220428 Latest Revision: 20220428 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.archger.2022.104647 |
| PMID: | 35134612 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't