Investigating Genetic and Other Determinants of First-Onset Myocardial Infarction in Malaysia: Protocol for the Malaysian Acute Vascular Events Risk Study.
| Title: | Investigating Genetic and Other Determinants of First-Onset Myocardial Infarction in Malaysia: Protocol for the Malaysian Acute Vascular Events Risk Study. |
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| Authors: | Chowdhury R; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; Centre for Non-Communicable Disease Research, Dhaka, Bangladesh.; Noh MFM; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia.; Ismail SR; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia.; van Daalen KR; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; Kamaruddin PSNM; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia.; Zulkiply SH; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia.; Azizul NH; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia.; Khalid NM; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia.; Ali A; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia.; Idris IM; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia.; Mei YS; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia.; Abdullah SR; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia.; Faridus N; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia.; Yusof NAM; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia.; Yusoff NNFM; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia.; Jamal R; UKM Medical Molecular Biological Institute, Kuala Lumpur, Malaysia.; Rahim AAA; National Heart Institute, Kuala Lumpur, Malaysia.; Ghapar AKA; Department of Cardiology, Hospital Serdang, Selangor, Malaysia.; Radhakrishnan AK; Jeffery Cheah School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, Malaysia.; Fong AYY; Department of Cardiology, Sarawak Heart Centre, Kota Samarahan, Malaysia.; Clinical Research Centre, Institute for Clinical Research, Sarawak General Hospital, Kuching, Malaysia.; Ismail O; Department of Cardiology, Hospital Pulau Pinang, Pulau Pinang, Malaysia.; Krishinan S; Department of Cardiology, Hospital Sultanah Bahiyah, Kedah, Malaysia.; Lee CY; Department of Cardiology, Hospital Sultanah Aminah, Johor, Malaysia.; Bang LH; Department of Cardiology & Clinical Research Centre, Hospital Queen Elizabeth II, Sabah, Malaysia.; Mageswaren E; Department of General Medicine, Hospital Tengku Ampuan Rahimah, Selangor, Malaysia.; Mahendran K; Department of General Medicine & Clinical Research Centre, Hospital Melaka, Melaka, Malaysia.; Amin NHM; Department of General Medicine, Hospital Raja Permaisuri Bainun, Perak, Malaysia.; Muthusamy G; Department of General Medicine, Hospital Shah Alam, Selangor, Malaysia.; Jin AOH; Department of General Medicine, Hospital Tuanku Fauziah, Perlis, Malaysia.; Ramli AW; Department of Cardiology, Hospital Sultanah Nur Zahirah, Terengganu, Malaysia.; Ross NT; Department of General Medicine, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.; Ruhani AI; Department of Cardiology, Hospital Tengku Ampuan Afzan, Pahang, Malaysia.; Yahya M; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia.; Yusoff Y; Department of General Medicine, Hospital Sungai Buloh, Selangor, Malaysia.; Abidin SKZ; Department of General Medicine, Hospital Tengku Ampuan Rahimah, Selangor, Malaysia.; Amado L; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; Bolton T; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom.; Weston S; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; Crawte J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; Ovenden N; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; Michielsen A; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; Monower MM; National Heart Foundation Hospital & Research Institute, Mirpur, Dhaka, Bangladesh.; Mahiyuddin WRW; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia.; Wood A; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom.; Di Angelantonio E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom.; Sulaiman NS; Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia.; Danesh J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom.; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom.; Butterworth AS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom. |
| Source: | JMIR research protocols [JMIR Res Protoc] 2022 Feb 10; Vol. 11 (2), pp. e31885. Date of Electronic Publication: 2022 Feb 10. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: JMIR Publications Country of Publication: Canada NLM ID: 101599504 Publication Model: Electronic Cited Medium: Print ISSN: 1929-0748 (Print) Linking ISSN: 19290748 NLM ISO Abbreviation: JMIR Res Protoc Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Toronto : JMIR Publications |
| Abstract: | Background: Although the burden of premature myocardial infarction (MI) is high in Malaysia, direct evidence on the determinants of MI in this multi-ethnic population remains sparse.; Objective: The Malaysian Acute Vascular Events Risk (MAVERIK) study is a retrospective case-control study established to investigate the genomic, lipid-related, and other determinants of acute MI in Malaysia. In this paper, we report the study protocol and early results.; Methods: By June 2019, we had enrolled approximately 2500 patients with their first MI and 2500 controls without cardiovascular disease, who were frequency-matched by age, sex, and ethnicity, from 17 hospitals in Malaysia. For each participant, serum and whole blood have been collected and stored. Clinical, demographic, and behavioral information has been obtained using a 200-item questionnaire.; Results: Tobacco consumption, a history of diabetes, hypertension, markers of visceral adiposity, indicators of lower socioeconomic status, and a family history of coronary disease were more prevalent in cases than in controls. Adjusted (age and sex) logistic regression models for traditional risk factors indicated that current smoking (odds ratio [OR] 4.11, 95% CI 3.56-4.75; P |
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| Grant Information: | MR/L003120/1 United Kingdom MRC_ Medical Research Council; MR/P013880/1 United Kingdom MRC_ Medical Research Council |
| Contributed Indexing: | Keywords: Malaysia; cardiovascular disease; case-control study; myocardial infarction |
| Entry Date(s): | Date Created: 20220210 Latest Revision: 20250530 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC8874931 |
| DOI: | 10.2196/31885 |
| PMID: | 35142634 |
| Database: | MEDLINE |
Journal Article