Impact of transmural plastic stent on recurrence of pancreatic fluid collection after metal stent removal in disconnected pancreatic duct: a randomized controlled trial.
| Title: | Impact of transmural plastic stent on recurrence of pancreatic fluid collection after metal stent removal in disconnected pancreatic duct: a randomized controlled trial. |
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| Authors: | Chavan R; Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.; Nabi Z; Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.; Lakhtakia S; Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.; Gupta R; Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.; Jahangeer B; Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.; Talukdar R; Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.; Singh AP; Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.; Karyampudi A; Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.; Yarlagadda R; Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.; Ramchandani M; Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.; Kalapala R; Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.; Jagtap N; Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.; Reddy M; Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.; Tandan M; Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.; Rao GV; Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.; Reddy ND; Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India. |
| Source: | Endoscopy [Endoscopy] 2022 Sep; Vol. 54 (9), pp. 861-868. Date of Electronic Publication: 2022 Feb 18. |
| Publication Type: | Randomized Controlled Trial; Journal Article |
| Language: | English |
| Journal Info: | Publisher: Georg Thieme Verlag Country of Publication: Germany NLM ID: 0215166 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1438-8812 (Electronic) Linking ISSN: 0013726X NLM ISO Abbreviation: Endoscopy Subsets: MEDLINE |
| Imprint Name(s): | Publication: Stuttgart : Georg Thieme Verlag; Original Publication: Stuttgart, Thieme. |
| MeSH Terms: | Pancreatic Diseases*/complications; Drainage/methods ; Endosonography/methods ; Necrosis/etiology ; Pancreatic Ducts/surgery ; Stents/adverse effects ; Adult ; Humans ; Male ; Metals ; Retrospective Studies ; Treatment Outcome |
| Abstract: | Background: Disconnected pancreatic duct (DPD) after development of walled-off necrosis (WON) predisposes to recurrent (peri)pancreatic fluid collection (PFC). In this randomized controlled trial, we compared plastic stents with no plastic stent after removal of a large-caliber metal stent (LCMS) on incidence of recurrent PFCs in DPD. METHODS : Consecutive patients with WON who underwent endoscopic ultrasound (EUS)-guided drainage with LCMS between September 2017 and March 2020 were screened for eligibility. At LCMS removal (4 weeks after drainage), patients with DPD were randomized to plastic stent or no stent groups. The primary outcome was incidence of recurrent PFC at 3 months. Secondary outcomes were technical success of plastic stent deployment, adverse events, stent migration, and recurrence of PFC at 6 and 12 months.; Results: 236 patients with WON underwent EUS-guided drainage using LCMS, and 104 (males 94, median age 34 years (interquartile range [IQR] 26-44.7) with DPD were randomized into stenting (n = 52) and no-stenting (n = 52) groups. Plastic stent deployment was successful in 88.5 %. Migration occurred in 19.2 % at median follow-up of 8 months (IQR 2.5-12). Recurrent PFCs occurred in six patients at 3 months (stent n = 3, no stent n = 3). There was no significant difference in PFC recurrence between the two groups at 3, 6, and 12 months. Reintervention was required in seven patients with recurrent PFCs, with no significant difference between the two groups.; Conclusion: In patients with WON and DPD, deployment of plastic stents after LCMS removal did not reduce recurrence of PFC.; (Thieme. All rights reserved.) |
| Competing Interests: | The authors declare that they have no conflict of interest. |
| Comments: | Comment in: Endoscopy. 2022 Jul;54(7):728. doi: 10.1055/a-1823-0974.. (PMID: 35764085); Comment in: Endoscopy. 2022 Sep;54(9):v29. doi: 10.1055/a-1757-6793.. (PMID: 36007507); Comment in: Endoscopy. 2023 Apr;55(4):395. doi: 10.1055/a-1949-0607.. (PMID: 36990080) |
| Molecular Sequence: | ClinicalTrials.gov NCT03436043 |
| Substance Nomenclature: | 0 (Metals) |
| Entry Date(s): | Date Created: 20220218 Date Completed: 20220829 Latest Revision: 20250728 |
| Update Code: | 20260130 |
| DOI: | 10.1055/a-1747-3283 |
| PMID: | 35180798 |
| Database: | MEDLINE |
Randomized Controlled Trial; Journal Article