The prevalence of pre-treatment and acquired HIV drug resistance in Vietnam: a nationally representative survey, 2017-2018.
| Title: | The prevalence of pre-treatment and acquired HIV drug resistance in Vietnam: a nationally representative survey, 2017-2018. |
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| Authors: | Dat VQ; Department of Infectious Diseases, Hanoi Medical University, Hanoi, Vietnam.; Anh NTL; National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.; Van Nghia K; Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Linh NT; National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.; Thu HHK; Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Tam TTM; National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.; Ton T; Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Anh LQ; Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Phuc ND; Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Huong PTT; Vietnam Administration for HIV/AIDS Control, Hanoi, Vietnam.; Nhan DT; Vietnam Administration for HIV/AIDS Control, Hanoi, Vietnam.; Hai NH; Vietnam Administration for HIV/AIDS Control, Hanoi, Vietnam.; Bertagnolio S; World Health Organization, Geneva, Switzerland.; Crisp AM; Department of Biostatistics, University of Florida, Gainesville, Florida, USA.; Inzaule S; World Health Organization, Geneva, Switzerland.; Dean NE; Department of Biostatistics, University of Florida, Gainesville, Florida, USA.; Jordan MR; Division of Geographic Medicine, Tufts Medical Center, Boston, Massachusetts, USA.; Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA.; Levy Center for Integrated Management of Antimicrobial Resistance (CIMAR), Boston, Massachusetts, USA.; Nguyen VTT; World Health Organization Vietnam Country Office, Hanoi, Vietnam. |
| Source: | Journal of the International AIDS Society [J Int AIDS Soc] 2022 Feb; Vol. 25 (2), pp. e25857. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: John Wiley & Sons, Inc Country of Publication: Switzerland NLM ID: 101478566 Publication Model: Print Cited Medium: Internet ISSN: 1758-2652 (Electronic) Linking ISSN: 17582652 NLM ISO Abbreviation: J Int AIDS Soc Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2017- : Hoboken, NJ : John Wiley & Sons, Inc; Original Publication: [London] : BioMed Central |
| MeSH Terms: | Anti-HIV Agents*/pharmacology ; Anti-HIV Agents*/therapeutic use ; HIV Infections*/drug therapy ; HIV Infections*/epidemiology; Vietnam/epidemiology ; Drug Resistance, Viral ; Humans ; Prevalence ; Viral Load |
| Abstract: | Introduction: Monitoring the population-level emergence and transmission of HIV drug resistance (HIVDR) is necessary for supporting public health programmes. This study provides a nationally representative prevalence estimate of HIVDR in people initiating antiretroviral therapy (ART) and estimates of acquired HIVDR and viral load (VL) suppression in people who have received it for 12 or ≥48 months in Vietnam.; Methods: The study was conducted between September 2017 and March 2018 following World Health Organization guidance. Thirty ART clinics were randomly sampled using probability proportional to size sampling from a total of 367 ART clinics in the country.; Results and Discussion: In total, 409 patients initiating ART were enrolled into the survey of pre-treatment HIVDR. The prevalence of any pre-treatment HIVDR was 5.8% (95% CI 3.4-9.5%), and the prevalence of non-nucleoside reverse transcriptase inhibitor resistance was 3.4% (95% CI 1.8-6.2%). Four hundred twenty-nine patients on ART for 12±3 months and 723 patients on ART for ≥48 months were enrolled into the surveys of acquired HIVDR. The prevalence of VL suppression (defined as |
| References: | J Antimicrob Chemother. 2018 Nov 1;73(11):3137-3142. (PMID: 30137412); J Antimicrob Chemother. 2015 Mar;70(3):941-7. (PMID: 25433009); Western Pac Surveill Response J. 2018 Aug 20;9(3):16-24. (PMID: 30377546); J Antimicrob Chemother. 2017 Feb;72(2):504-510. (PMID: 27789684); Lancet Infect Dis. 2018 Mar;18(3):346-355. (PMID: 29198909); J Antimicrob Chemother. 2019 Feb 1;74(2):462-467. (PMID: 30418575); Clin Infect Dis. 2004 Oct 1;39(7):1030-7. (PMID: 15472857); J Antimicrob Chemother. 2018 Sep 1;73(9):2468-2474. (PMID: 29931063) |
| Grant Information: | 001 International WHO_ World Health Organization |
| Contributed Indexing: | Keywords: HIV; Vietnam; acquired HIV drug resistance; pre-treatment HIV drug resistance; surveillance; viral suppression |
| Substance Nomenclature: | 0 (Anti-HIV Agents) |
| Entry Date(s): | Date Created: 20220223 Date Completed: 20220503 Latest Revision: 20250530 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC8864494 |
| DOI: | 10.1002/jia2.25857 |
| PMID: | 35194954 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't