[Specific experimental therapy in sensitization to group A streptococci].
| Title: | [Specific experimental therapy in sensitization to group A streptococci]. |
|---|---|
| Transliterated Title: | Spetsificheskaia eksperimental'naia terapiia pri sensibilizatsii k streptokokku gruppy A. |
| Authors: | Nugmanova ZhS; Sukhodoeva GS; Beklemishev ND |
| Source: | Zhurnal mikrobiologii, epidemiologii i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] 1978 Feb (2), pp. 120-5. |
| Publication Type: | Comparative Study; English Abstract; Journal Article |
| Language: | Russian |
| Journal Info: | Publisher: FBUN T︠S︡NII Ėpidemiologii Rospotrebnadzora Country of Publication: Russia (Federation) NLM ID: 0415217 Publication Model: Print Cited Medium: Print ISSN: 0372-9311 (Print) Linking ISSN: 03729311 NLM ISO Abbreviation: Zh Mikrobiol Epidemiol Immunobiol Subsets: MEDLINE |
| Imprint Name(s): | Publication: : Moskva : FBUN T︠S︡NII Ėpidemiologii Rospotrebnadzora; Original Publication: Moskva : Izd-vo "Medit︠s︡ina" |
| MeSH Terms: | Desensitization, Immunologic*; Hypersensitivity, Delayed/*therapy ; Streptococcus pyogenes/*immunology; Allergens/administration & dosage ; Animals ; Guinea Pigs ; Injections, Intradermal ; Injections, Intravenous ; Injections, Subcutaneous ; Rabbits |
| Abstract: | A model of delayed hypersensitivity to Streptococcus hemolyticus, group A, were obtained in guinea pigs and rabbits. Studies of spontaneous changes of the immuno-allergic reactivity revealed that after a month of sensitization there developed delayed hypersensitivity only; according to the results of late skin tests it lasted not less than 6 months (the duration of investigation). The delayed hypersensitivity component began to manifest itself in 2 1/2 to 3 months and increased later on. Specific hyposensitization was performed with streptococcus allergens differing by physico-chemical conditions, i.e. the corpuscula allergen, the one that was lysed by ultrasonic waves, and Ando-Verzhikovsky's allergen. The latter had the most intensive hyposensitizing features. Specific hyposensitization was more demonstrative after the intracutaneous long-term course injections of threshold doses. Administration of subthreshold doses, as well as subcutaneous or intravenous injections of the allergen, was ineffective. |
| Substance Nomenclature: | 0 (Allergens) |
| Entry Date(s): | Date Created: 19780201 Date Completed: 19780828 Latest Revision: 20200716 |
| Update Code: | 20260130 |
| PMID: | 352043 |
| Database: | MEDLINE |
Comparative Study; English Abstract; Journal Article