mTOR signaling as a molecular target for the alleviation of Alzheimer's disease pathogenesis.
| Title: | mTOR signaling as a molecular target for the alleviation of Alzheimer's disease pathogenesis. |
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| Authors: | Rapaka D; A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, 530003, India. Electronic address: deepthirapaka7@gmail.com.; Bitra VR; School of Pharmacy, University of Botswana, Gaborone, Private bag-0022, Botswana.; Challa SR; Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, Peoria, IL, 61614, USA.; Adiukwu PC; School of Pharmacy, University of Botswana, Gaborone, Private bag-0022, Botswana. |
| Source: | Neurochemistry international [Neurochem Int] 2022 May; Vol. 155, pp. 105311. Date of Electronic Publication: 2022 Feb 23. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Pergamon Press Country of Publication: England NLM ID: 8006959 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9754 (Electronic) Linking ISSN: 01970186 NLM ISO Abbreviation: Neurochem Int Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford [Elmsford, N. Y.] Pergamon Press. |
| MeSH Terms: | Alzheimer Disease*/metabolism; Mammals/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Animals ; Autophagy ; Humans ; Signal Transduction ; Sirolimus |
| Abstract: | Mechanistic/mammalian target of rapamycin (mTOR) belongs to the phosphatidylinositol kinase-related kinase (PIKK) family. mTOR signaling is required for the commencement of essential cell functions including autophagy. mTOR primarily governs cell growth in response to favourable nutrients and other growth stimuli. However, it also influences aging and other aspects of nutrient-related physiology such as protein synthesis, ribosome biogenesis, and cell proliferation in adults with very limited growth. The major processes for survival such as synaptic plasticity, memory storage and neuronal recovery involve a significant mTOR activity. mTOR dysregulation is becoming a prevalent motif in a variety of human diseases, including cancer, neurological disorders, and other metabolic syndromes. The use of rapamycin to prolong life in different animal models may be attributable to the multiple roles played by mTOR signaling in various processes involved in ageing, protein translation, autophagy, stem cell pool turnover, inflammation, and cellular senescence. mTOR activity was found to be altered in AD brains and rodent models, supporting the notion that aberrant mTOR activity is one of the key events contributing to the onset and progression of AD hallmarks This review assesses the molecular association between the mTOR signaling pathway and pathogenesis of Alzheimer's disease. The research data supporting this theme are also reviewed.; (Copyright © 2022 Elsevier Ltd. All rights reserved.) |
| Contributed Indexing: | Keywords: Alzheimer's disease; Apoptosis; Cognition; Macroautophagy; Rapamycin; mTOR |
| Substance Nomenclature: | EC 2.7.11.1 (TOR Serine-Threonine Kinases); W36ZG6FT64 (Sirolimus) |
| Entry Date(s): | Date Created: 20220226 Date Completed: 20220407 Latest Revision: 20220531 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.neuint.2022.105311 |
| PMID: | 35218870 |
| Database: | MEDLINE |
Journal Article; Review