Mean platelet volume as a predictor of platelet count recovery in dengue patients.
| Title: | Mean platelet volume as a predictor of platelet count recovery in dengue patients. |
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| Authors: | Martínez-Ruíz DM; Fundación Valle del Lili, Centro de Investigaciones Clínicas (CIC), Cra 98 No. 18 - 49, Cali 760032, Colombia.; Tovar-Rios DA; Universidad de Icesi, Escuela de Ciencias de la Educación, Departamento de Matemáticas y Estadística, Calle 18 No. 122-135, Cali 760031, Colombia.; Universidad del Valle, Facultad de Ingeniería, Escuela de Estadística, Calle 13 No. 100-00, Cali 760032, Colombia.; Valencia-Orozco A; Fundación Valle del Lili, Centro de Investigaciones Clínicas (CIC), Cra 98 No. 18 - 49, Cali 760032, Colombia.; Florez-Elvira LJ; Fundación Valle del Lili, Centro de Investigaciones Clínicas (CIC), Cra 98 No. 18 - 49, Cali 760032, Colombia.; Agudelo OL; Fundación Valle del Lili, Centro de Investigaciones Clínicas (CIC), Cra 98 No. 18 - 49, Cali 760032, Colombia.; Parra-Lara LG; Fundación Valle del Lili, Centro de Investigaciones Clínicas (CIC), Cra 98 No. 18 - 49, Cali 760032, Colombia.; Universidad Icesi, Facultad de Ciencias de la Salud, Cali 760031, Colombia.; Rosso F; Fundación Valle del Lili, Centro de Investigaciones Clínicas (CIC), Cra 98 No. 18 - 49, Cali 760032, Colombia.; Universidad Icesi, Facultad de Ciencias de la Salud, Cali 760031, Colombia.; Fundación Valle del Lili, Departamento de Medicina Interna, Servicio de Infectología, Cali, Valle del Cauca, Colombia, Cra 98 No. 18 - 49, Cali 760032, Colombia. |
| Source: | Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2022 Sep 10; Vol. 116 (9), pp. 798-806. |
| Publication Type: | Journal Article; Observational Study |
| Language: | English |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 7506129 Publication Model: Print Cited Medium: Internet ISSN: 1878-3503 (Electronic) Linking ISSN: 00359203 NLM ISO Abbreviation: Trans R Soc Trop Med Hyg Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2013- : Oxford : Oxford University Press; Original Publication: 1920- : London : Royal Society of Tropical Medicine and Hygiene |
| MeSH Terms: | Dengue*/diagnosis ; Thrombocytopenia*; Adult ; Biomarkers ; Female ; Humans ; Male ; Mean Platelet Volume ; Platelet Count |
| Abstract: | Background: Thrombocytopenia is a marker of severity in dengue, and its resolution predicts clinical improvement. The objective was to evaluate mean platelet volume (MPV) trajectories as a predictor of platelet count (PC) recovery in dengue patients.; Methods: An observational, longitudinal and analytical study was conducted at Fundación Valle del Lili (Cali, Colombia). Patients diagnosed with dengue during 2016-2020 were included. The association between PC and the covariates was evaluated using simple linear, quadratic and non-parametric spline smoothing regression models. A longitudinal linear mixed model was adjusted and then validated for PC measurements.; Results: A total of 71 patients were included. The median age was 27 y, 38.5% were women and half had dengue with warning signs. A statistically significant PC decrease was observed when MPV was 13.87 fL and 4.46 d from the onset of symptoms, while PC displayed a significant constant increase with neutrophils count. Then, PC recovery was achieved with an MPV of 13.58 fL, 4.5 d from the onset of symptoms and a minimum neutrophils count of 150 μL.; Conclusion: MPV may be a predictor of PC recovery in dengue patients. PC recovery is expected when a patient has an MPV of 13.58 fL, an onset time of 4.5 d and a neutrophils count of 150 μL.; (© The Author(s) 2022. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.) |
| Contributed Indexing: | Keywords: dengue; linear mixed model; mean platelet volume; platelet count; thrombocytopenia |
| Substance Nomenclature: | 0 (Biomarkers) |
| Entry Date(s): | Date Created: 20220227 Date Completed: 20220913 Latest Revision: 20250728 |
| Update Code: | 20260130 |
| DOI: | 10.1093/trstmh/trac008 |
| PMID: | 35220437 |
| Database: | MEDLINE |
Journal Article; Observational Study