Characterization of a Clostridioides difficile outbreak caused by PCR ribotype 046, associated with increased mortality.
| Title: | Characterization of a Clostridioides difficile outbreak caused by PCR ribotype 046, associated with increased mortality. |
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| Authors: | Magnusson C; Department of Infectious Diseases, Region Jönköping County, Jönköping and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.; Mernelius S; Laboratory Medicine, Region Jönköping County, Jönköping and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.; Bengnér M; Office for control of Communicable Diseases, Region Jönköping County, Jönköping, Sweden.; Norén T; Faculty of Medicine and Health, Department of Laboratory Medicine, National Reference Laboratory for Clostridioides difficile, Clinical Microbiology, Örebro University, Örebro, Sweden.; Serrander L; Division of Clinical Microbiology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.; Forshell S; Department of Infectious Diseases, Region Jönköping County, Jönköping and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.; Matussek A; Laboratory Medicine, Region Jönköping County, Jönköping and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.; Division of Laboratory Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Laboratory Medicine, Oslo University Hospital, Oslo, Norway. |
| Source: | Emerging microbes & infections [Emerg Microbes Infect] 2022 Dec; Vol. 11 (1), pp. 850-859. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2019- : [Philadelphia, PA] : Taylor & Francis; Original Publication: New York : NPG, 2012-2018. |
| MeSH Terms: | Clostridioides difficile*/genetics ; Clostridium Infections*/epidemiology; Clostridioides ; Disease Outbreaks ; Humans ; Polymerase Chain Reaction ; Ribotyping |
| Abstract: | This study describes a large nosocomial outbreak of Clostridioides difficile infections (CDI) dominated by ribotype (RT) 046 in a Swedish hospital. The present study aimed to examine the pathogenicity of this RT, explore epidemiological links by whole genome sequencing (WGS), and evaluate different interventions implemented to stop the outbreak. Clinical isolates (n = 366) collected during and after the outbreak were ribotyped and 246 isolates were subjected to WGS. Medical records of patients infected with the seven most common RTs were evaluated. RT046 was spread effectively throughout the hospital and was the most common among the 44 different RTs found (114/366 isolates). Infection with RT046 was associated with higher mortality compared to other strains (20.2% to 7.8%), although there were no differences in concomitant disease, age or antibiotic treatment. To control the outbreak, several measures were successfully implemented. |
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| Contributed Indexing: | Keywords: CDI; Clostridioides difficile; epidemiology; mortality; outbreak; ribotyping; whole-genome sequencing |
| Entry Date(s): | Date Created: 20220304 Date Completed: 20220323 Latest Revision: 20220329 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC8942542 |
| DOI: | 10.1080/22221751.2022.2049981 |
| PMID: | 35240942 |
| Database: | MEDLINE |
Journal Article