Long-Term Health-Related Quality of Life in Non-Hospitalized Coronavirus Disease 2019 (COVID-19) Cases With Confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in England: Longitudinal Analysis and Cross-Sectional Comparison With Controls.
| Title: | Long-Term Health-Related Quality of Life in Non-Hospitalized Coronavirus Disease 2019 (COVID-19) Cases With Confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in England: Longitudinal Analysis and Cross-Sectional Comparison With Controls. |
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| Authors: | Sandmann FG; Statistics, Modelling and Economics Department, UK Health Security Agency, London, United Kingdom.; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.; Tessier E; Immunisation Division, UK Health Security Agency, London, United Kingdom.; COVID-19 National Epidemiology Cell, UK Health Security Agency, London, United Kingdom.; Lacy J; Immunisation Division, UK Health Security Agency, London, United Kingdom.; Kall M; COVID-19 National Epidemiology Cell, UK Health Security Agency, London, United Kingdom.; Van Leeuwen E; Statistics, Modelling and Economics Department, UK Health Security Agency, London, United Kingdom.; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.; Charlett A; Statistics, Modelling and Economics Department, UK Health Security Agency, London, United Kingdom.; Eggo RM; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.; Dabrera G; COVID-19 National Epidemiology Cell, UK Health Security Agency, London, United Kingdom.; Edmunds WJ; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.; Ramsay M; Immunisation Division, UK Health Security Agency, London, United Kingdom.; Campbell H; Immunisation Division, UK Health Security Agency, London, United Kingdom.; Amirthalingam G; Immunisation Division, UK Health Security Agency, London, United Kingdom.; Jit M; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom. |
| Source: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2022 Aug 24; Vol. 75 (1), pp. e962-e973. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| Imprint Name(s): | Publication: Jan. 2011- : Oxford : Oxford University Press; Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| MeSH Terms: | COVID-19* ; SARS-CoV-2*; Adult ; Cross-Sectional Studies ; Female ; Humans ; Male ; Prospective Studies ; Quality of Life |
| Abstract: | Background: We aimed to quantify the unknown losses in health-related quality of life of coronavirus disease 2019 (COVID-19) cases using quality-adjusted lifedays (QALDs) and the recommended EQ-5D instrument in England.; Methods: Prospective cohort study of nonhospitalized, polymerase chain reaction (PCR)-confirmed severe acute respiratory syndrome coronavirus 2-positive (SARS-CoV-2-positive) cases aged 12-85 years and followed up for 6 months from 1 December 2020, with cross-sectional comparison to SARS-CoV-2-negative controls. Main outcomes were QALD losses; physical symptoms; and COVID-19-related private expenditures. We analyzed results using multivariable regressions with post hoc weighting by age and sex, and conditional logistic regressions for the association of each symptom and EQ-5D limitation on cases and controls.; Results: Of 548 cases (mean age 41.1 years; 61.5% female), 16.8% reported physical symptoms at month 6 (most frequently extreme tiredness, headache, loss of taste and/or smell, and shortness of breath). Cases reported more limitations with doing usual activities than controls. Almost half of cases spent a mean of £18.1 on nonprescription drugs (median: £10.0), and 52.7% missed work or school for a mean of 12 days (median: 10). On average, all cases lost 13.7 (95% confidence interval [CI]: 9.7, 17.7) QALDs, whereas those reporting symptoms at month 6 lost 32.9 (95% CI: 24.5, 37.6) QALDs. Losses also increased with older age. Cumulatively, the health loss from morbidity contributes at least 18% of the total COVID-19-related disease burden in the England.; Conclusions: One in 6 cases report ongoing symptoms at 6 months, and 10% report prolonged loss of function compared to pre-COVID-19 baselines. A marked health burden was observed among older COVID-19 cases and those with persistent physical symptoms.; (© Crown copyright 2022.) |
| Contributed Indexing: | Keywords: 19; 2; COVID; CoV; QALYs; SARS; health; long COVID; related quality of life |
| Entry Date(s): | Date Created: 20220304 Date Completed: 20220829 Latest Revision: 20250728 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC8903473 |
| DOI: | 10.1093/cid/ciac151 |
| PMID: | 35245941 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't