Chiropractic Spinal Manipulation Prevents Secondary Hyperalgesia Induced by Topical Capsaicin in Healthy Individuals.
| Title: | Chiropractic Spinal Manipulation Prevents Secondary Hyperalgesia Induced by Topical Capsaicin in Healthy Individuals. |
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| Authors: | Gevers-Montoro C; Department of Anatomy, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; Madrid College of Chiropractic, RCU Maria Cristina, Madrid, Spain.; Provencher B; Department of Anatomy, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; Northon S; Department of Anatomy, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; Stedile-Lovatel JP; Madrid College of Chiropractic, RCU Maria Cristina, Madrid, Spain.; Ortega de Mues A; Madrid College of Chiropractic, RCU Maria Cristina, Madrid, Spain.; Piché M; Department of Anatomy, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada. |
| Source: | Frontiers in pain research (Lausanne, Switzerland) [Front Pain Res (Lausanne)] 2021 Jul 20; Vol. 2, pp. 702429. Date of Electronic Publication: 2021 Jul 20 (Print Publication: 2021). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Frontiers Country of Publication: Switzerland NLM ID: 9918227269806676 Publication Model: eCollection Cited Medium: Internet ISSN: 2673-561X (Electronic) Linking ISSN: 2673561X NLM ISO Abbreviation: Front Pain Res (Lausanne) Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Lausanne : Frontiers, [2020]- |
| Abstract: | Background and Aims: Spinal manipulation (SM) is currently recommended for the management of back pain. Experimental studies indicate that the hypoalgesic mechanisms of SM may rely on inhibition of segmental processes related to temporal summation of pain and, possibly, on central sensitization, although this remains unclear. The aim of this study was to determine whether experimental back pain, secondary hyperalgesia, and pain-related brain activity induced by capsaicin are decreased by segmental SM. Methods: Seventy-three healthy volunteers were randomly allocated to one of four experimental groups: SM at T5 vertebral level (segmental), SM at T9 vertebral level (heterosegmental), placebo intervention at T5 vertebral level, or no intervention. Topical capsaicin was applied to the area of T5 vertebra for 40 min. After 20 min, the interventions were administered. Pressure pain thresholds (PPTs) were assessed outside the area of capsaicin application at 0 and 40 min to examine secondary hyperalgesia. Capsaicin pain intensity and unpleasantness were reported every 4 min. Frontal high-gamma oscillations were also measured with electroencephalography. Results: Pain ratings and brain activity were not significantly different between groups over time (p > 0.5). However, PPTs were significantly decreased in the placebo and control groups (p < 0.01), indicative of secondary hyperalgesia, while no hyperalgesia was observed for groups receiving SM (p = 1.0). This effect was independent of expectations and greater than placebo for segmental (p < 0.01) but not heterosegmental SM (p = 1.0). Conclusions: These results indicate that segmental SM can prevent secondary hyperalgesia, independently of expectations. This has implications for the management of back pain, particularly when central sensitization is involved.; (Copyright © 2021 Gevers-Montoro, Provencher, Northon, Stedile-Lovatel, Ortega de Mues and Piché.) |
| Competing Interests: | The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
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| Contributed Indexing: | Keywords: back pain; central sensitization; chiropractic adjustment; gamma band oscillations; manual therapy; pressure pain threshold |
| Entry Date(s): | Date Created: 20220317 Latest Revision: 20240825 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC8915757 |
| DOI: | 10.3389/fpain.2021.702429 |
| PMID: | 35295504 |
| Database: | MEDLINE |
Journal Article