Timed Up and Go in People with Subjective Cognitive Decline Is Associated with Faster Cognitive Deterioration and Cortical Thickness.
| Title: | Timed Up and Go in People with Subjective Cognitive Decline Is Associated with Faster Cognitive Deterioration and Cortical Thickness. |
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| Authors: | Borda MG; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway.; Semillero de Neurociencias y Envejecimiento, Ageing Institute, Medical School Pontificia Universidad Javeriana, Bogotá, Colombia.; Faculty of Health Sciences, University of Stavanger, Stavanger, Norway.; Ferreira D; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Selnes P; Department of Neurology, Akershus University Hospital, Lørenskog, Norway.; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.; Tovar-Rios DA; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway.; Faculty of Health Sciences, University of Stavanger, Stavanger, Norway.; Universidad Del Valle, Santiago De Cali, Colombia.; Jaramillo-Jiménez A; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway.; Faculty of Health Sciences, University of Stavanger, Stavanger, Norway.; Grupo de Neurociencias de Antioquia, School of Medicine, Universidad de Antioquia, Medellín, Colombia.; Kirsebom BE; Department of Neurology, University Hospital of North Norway, Tromsø, Norway.; Department of Psychology, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway.; Garcia-Cifuentes E; Semillero de Neurociencias y Envejecimiento, Ageing Institute, Medical School Pontificia Universidad Javeriana, Bogotá, Colombia.; Unidad de Neurologia, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá, Colombia.; Dalaker TO; Stavanger Medical Imaging Laboratory, Department of Radiology, Stavanger University Hospital, Stavanger, Norway.; Oppedal K; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway.; Department of Electrical Engineering and Computer Science, University of Stavanger, Stavanger, Norway.; Sønnesyn H; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway.; Fladby T; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.; Universidad Del Valle, Santiago De Cali, Colombia.; Aarsland D; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway.; Department of Old Age Psychiatry, King's College, London, United Kingdom. |
| Source: | Dementia and geriatric cognitive disorders [Dement Geriatr Cogn Disord] 2022; Vol. 51 (1), pp. 63-72. Date of Electronic Publication: 2022 Mar 25. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Karger Country of Publication: Switzerland NLM ID: 9705200 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1421-9824 (Electronic) Linking ISSN: 14208008 NLM ISO Abbreviation: Dement Geriatr Cogn Disord Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel ; New York : Karger, c1997- |
| MeSH Terms: | Cognitive Dysfunction*/psychology ; Alzheimer Disease*; Cognition ; Cohort Studies ; Cross-Sectional Studies ; Humans ; Prospective Studies |
| Abstract: | Introduction: Early markers of neurodegeneration provide an opportunity to detect, monitor, and initiate interventions in individuals who have an increased risk of developing dementia. Here, we investigated whether the Timed Up and Go (TUG) test is associated with early brain neurodegeneration and whether the TUG test could be a marker of cognitive decline in people with subjective cognitive decline (SCD).; Methods: This is a longitudinal analysis of the Dementia Disease Initiation Study, a prospective, community-based, cohort study from Norway, designed to investigate early markers of cognitive impairment and dementia. Participants were classified as SCD and healthy controls (HC). The main studied variables were the TUG test and cognition as measured by the Mini-Mental State Examination and the Consortium to Establish a Registry for Alzheimer's Disease memory composite score. Additionally, we investigated the cross-sectional association of brain morphology with the TUG using 1.5T-MRI.; Results: The sample included 45 participants (SCD = 21, HC = 24) followed during a mean time of 1.50 ± 0.70 years. At baseline, the cognitive performance did not differ between the groups, but TUG was longer in SCD. Slower baseline TUG was associated with a faster cognitive decline in both groups and it was also associated with reduced cortical thickness especially in motor, executive, associative, and somatosensory cortical regions in people with SCD.; Discussion/conclusion: TUG predicted cognitive change in individuals with SCD, and there was a negative association between TUG and cortical thickness. TUG is a promising cheap and noninvasive marker of early cognitive decline and may help initiate interventions in individuals who have an increased risk of dementia.; (© 2022 S. Karger AG, Basel.) |
| Grant Information: | United Kingdom DH_ Department of Health |
| Contributed Indexing: | Keywords: Dementia; Gait; Neuroimaging; Physical performance; Predementia |
| Entry Date(s): | Date Created: 20220327 Date Completed: 20220421 Latest Revision: 20220520 |
| Update Code: | 20260130 |
| DOI: | 10.1159/000522094 |
| PMID: | 35339996 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't