Systematic review of disulfiram as an antibacterial agent: what is the evidence?
| Title: | Systematic review of disulfiram as an antibacterial agent: what is the evidence? |
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| Authors: | Meneguello JE; Graduate Program in Biosciences and Physiopathology, State University of Maringá, 87020-900, Maringá-PR, Brazil.; Murase LS; Graduate Program in Health Sciences, State University of Maringá, 87020-900, Maringá-PR, Brazil.; de Souza JVP; Graduate Program in Biosciences and Physiopathology, State University of Maringá, 87020-900, Maringá-PR, Brazil.; de Oliveira CG; Graduate Program in Health Sciences, State University of Maringá, 87020-900, Maringá-PR, Brazil.; Ghiraldi-Lopes LD; Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020-900, Maringá-PR, Brazil.; Teixeira JJV; Graduate Program in Biosciences and Physiopathology, State University of Maringá, 87020-900, Maringá-PR, Brazil; Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020-900, Maringá-PR, Brazil.; Scodro RBL; Graduate Program in Health Sciences, State University of Maringá, 87020-900, Maringá-PR, Brazil; Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020-900, Maringá-PR, Brazil.; Ferracioli KRC; Graduate Program in Biosciences and Physiopathology, State University of Maringá, 87020-900, Maringá-PR, Brazil; Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020-900, Maringá-PR, Brazil.; Siqueira VLD; Graduate Program in Biosciences and Physiopathology, State University of Maringá, 87020-900, Maringá-PR, Brazil; Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020-900, Maringá-PR, Brazil.; Campanerut-Sá PAZ; Graduate Program in Health Sciences, State University of Maringá, 87020-900, Maringá-PR, Brazil; Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020-900, Maringá-PR, Brazil.; Cardoso RF; Graduate Program in Biosciences and Physiopathology, State University of Maringá, 87020-900, Maringá-PR, Brazil; Graduate Program in Health Sciences, State University of Maringá, 87020-900, Maringá-PR, Brazil; Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020-900, Maringá-PR, Brazil. Electronic address: rfcardoso@uem.br. |
| Source: | International journal of antimicrobial agents [Int J Antimicrob Agents] 2022 May; Vol. 59 (5), pp. 106578. Date of Electronic Publication: 2022 Apr 01. |
| Publication Type: | Journal Article; Systematic Review |
| Language: | English |
| Journal Info: | Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 9111860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7913 (Electronic) Linking ISSN: 09248579 NLM ISO Abbreviation: Int J Antimicrob Agents Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier Science Publishers, c1991- |
| MeSH Terms: | Bacterial Infections*/drug therapy ; Anti-Infective Agents*; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Disulfiram/pharmacology ; Disulfiram/therapeutic use ; Animals ; Gram-Positive Bacteria |
| Abstract: | The objective of this systematic review was to retrieve and examine published studies related to in vitro and in vivo evaluation of disulfiram for the treatment of bacterial infections. Five scientific databases (PubMed, Embase, Scopus, Web of Science, and Latin American and Caribbean Health Sciences Literature) were searched to retrieve the maximum literature regarding the study's aim. The search strategy retrieved a total of 870 studies, of which 31 were included and 19 approached disulfiram as the primary aim and 12 included it as a secondary finding from other investigational objectives. The evidence pointed out five main aspects of pre-clinical testing regarding disulfiram antibacterial activity, namely spectrum of antimicrobial action, drug combinations, intracellular studies, animal studies and bacterial targets. Findings to emerge from this study are the observed potential of disulfiram as a non-antibiotic drug being proposed as a potential drug to contribute to the treatment of bacterial diseases usually with few treatment alternatives in the context of drug resistance. We evaluated the potency and selectivity of disulfiram, which indeed until now shows potential to be explored for use as an adjunctive chemical to antimicrobial ones. Even with the level of evidence being reserved, the potential of combining disulfiram with other drugs, already used or new to be used for the treatment of mycobacterial diseases, as well as its likely immunomodulatory effect, deserve to be further investigated. Furthermore, the copper-dependent mode of action in Gram-positive bacteria is an alternative to be explored in drug design or repurposing of chemicals.; (Copyright © 2022 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.) |
| Contributed Indexing: | Keywords: Bacterial infection; Disulfiram; Drug repurposing; Drug resistance |
| Substance Nomenclature: | 0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents); TR3MLJ1UAI (Disulfiram) |
| Entry Date(s): | Date Created: 20220403 Date Completed: 20220510 Latest Revision: 20250623 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.ijantimicag.2022.106578 |
| PMID: | 35367599 |
| Database: | MEDLINE |
Journal Article; Systematic Review