The role of procoagulant phospholipids on the surface of circulating blood cells in thrombosis and haemostasis.
| Title: | The role of procoagulant phospholipids on the surface of circulating blood cells in thrombosis and haemostasis. |
|---|---|
| Authors: | Protty MB; Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, UK.; Jenkins PV; Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, UK.; Collins PW; Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, UK.; O'Donnell VB; Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, UK. |
| Source: | Open biology [Open Biol] 2022 Apr; Vol. 12 (4), pp. 210318. Date of Electronic Publication: 2022 Apr 20. |
| Publication Type: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Royal Society Pub Country of Publication: England NLM ID: 101580419 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2046-2441 (Electronic) Linking ISSN: 20462441 NLM ISO Abbreviation: Open Biol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Royal Society Pub., [2011]- |
| MeSH Terms: | Phospholipids*/chemistry ; Phospholipids*/metabolism ; Thrombosis*; Blood Cells/metabolism ; Blood Coagulation ; Hemostasis ; Humans |
| Abstract: | Phospholipids (PLs) are found in all cell types and are required for structural support and cell activation signalling pathways. In resting cells, PLs are asymmetrically distributed throughout the plasma membrane with native procoagulant aminophospholipids (aPLs) being actively maintained in the inner leaflet of the membrane. Upon platelet activation, aPLs rapidly externalize to the outer leaflet and are essential for supporting the coagulation cascade by providing binding sites for factors in the cell-based model. More recent work has uncovered a role for enzymatically oxidized PLs (eoxPLs) in facilitating coagulation, working in concert with native aPLs. Despite this, the role of aPLs and eoxPLs in thrombo-inflammatory conditions, such as arterial and venous thrombosis, has not been fully elucidated. In this review, we describe the biochemical structures, distribution and regulation of aPL externalization and summarize the literature on eoxPL generation in circulating blood cells. We focus on the currently understood role of these lipids in mediating coagulation reactions in vitro, in vivo and in human thrombotic disease. Finally, we highlight gaps in our understanding in how these lipids vary in health and disease, which may place them as future therapeutic targets for the management of thrombo-inflammatory conditions. |
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| Grant Information: | RG/F/20/110020 United Kingdom BHF_ British Heart Foundation; 216278/Z/19/Z United Kingdom WT_ Wellcome Trust |
| Contributed Indexing: | Keywords: coagulation; lipidomics; phospholipids; thrombosis |
| Substance Nomenclature: | 0 (Phospholipids) |
| Entry Date(s): | Date Created: 20220420 Date Completed: 20220421 Latest Revision: 20250530 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9019515 |
| DOI: | 10.1098/rsob.210318 |
| PMID: | 35440201 |
| Database: | MEDLINE |
Journal Article; Review; Research Support, Non-U.S. Gov't